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Menzel Abderhaman, Tunisia

Mlika M.,Tunis el Manar University | Braham E.,Tunis el Manar University | Hamrouni R.,Tunis el Manar University | Zribi H.,Abderrahman Mami Hospital | El Mezni F.,Tunis el Manar University
Asian Cardiovascular and Thoracic Annals | Year: 2015

Mediastinal hemangiomas are rare, accounting for 0.5% of all mediastinal tumors. These tumors are challenging because of the lack of specific clinical and radiologic signs. We report a 10-year experience of 5 mediastinal hemangiomas in a single institution, with neurologic signs related to neuroforaminal extension in 2 cases. Surgical treatment was performed in all 5 patients, without complications after a follow-up period varying from 9 months to 2 years. © The Author(s) 2014. Source

Chouchane L.,Cornell College | Boussen H.,Abderrahman Mami Hospital | Sastry K.S.R.,Cornell College
The Lancet Oncology | Year: 2013

Breast cancer is a major health problem in both developing and developed countries. It is the most frequently diagnosed female malignant disease in Arab populations. The incidence of breast cancer is lower in Arab countries than in Europe and the USA but is rising fast. Breast cancers in women from Arab populations have different characteristics to those reported in individuals from Europe and the USA. For example, affected patients are at least a decade younger, they have a more advanced stage of disease at first presentation, and their tumour size is larger. Moreover, in some Arab populations, reports suggest increased axillary-lymph-node invasion, a larger proportion of negative hormone receptors, and a higher tumour grade. These disparities are not only confined to clinicopathological features but also exist at the molecular level, as shown by findings of genome-wide association studies and expression profiling. © 2013 Elsevier Ltd. Source

Mlika M.,Tunis el Manar University | Ben Youssef A.,Abderrahman Mami Hospital | Hamrouni R.,Abderrahman Mami Hospital | Ayadi-Kaddour A.,Tunis el Manar University | And 2 more authors.
Pathologica | Year: 2013

Cardiac myxomas are the most common benign tumours of the heart. In spite of their benign nature, these tumours may induce metastasis or recurrences. Their diagnosis is challenging because of the lack of specific signs, and positive diagnosis is based on microscopic findings. We report a case series of 6 patients documented by radiologic and microscopic findings. In addition, one case was unique due to its location in the right atrium. Tumours were detected by trans-oesophageal ultra-sound examination in all cases. They were located in the left atrium in five cases and in the right side in one case. All patients underwent a successful surgical excision with en-bloc removal of the tumour. The outcome was fatal in one patient because of atrial arrhythmia. Source

Hamzaoui A.,Abderrahman Mami Hospital | Hamzaoui A.,Tunis el Manar University | Berraies A.,Abderrahman Mami Hospital | Berraies A.,Tunis el Manar University | And 6 more authors.
Immunobiology | Year: 2014

Vitamin D [25(OH)D3] deficiency has been associated with asthma as in many inflammatory and autoimmune pathologies; however, there is still a lack of data about the effects of administration of vitamin D in immune regulation in young asthmatic patients. In this study, we investigated its inhibitory effect on the immune response in young asthmatic patients and the possible mechanisms involved.Peripheral blood CD4+ T cells from 10 asthmatic patients and 10 healthy controls were cultured under Th17 polarizing conditions in the presence or absence of [25(OH)D3], IL-17 cytokine production was determined by ELISA and flow cytometry. Messenger RNA (mRNA) expression of several factors related to Th17 cell function was determined by real-time PCR. The effect of [25(OH)D3]-treated dendritic cells (DCs) on CD4+ T cell response was determined by ELISA and flow cytometry.Stimulation of naive CD4+ T cells under Th17 polarizing conditions showed a higher Th17 cell differentiation in asthmatic patients than healthy controls. The addition of [25(OH)D3] significantly inhibited Th17 cell differentiation both in patients [P<0.001] and in normal controls [P=0.001] in a dose-dependent way. [25(OH)D3] was able to inhibit the gene expression of RORC, IL-17, IL-23R, and CCR6. [25(OH)D3]-treated DCs significantly inhibited IL-17 production [P=0.002] and decreased the percentage of CD4+IL-17+ [P=0.007] in young asthmatics.The findings suggest that the inhibitory effect of [25(OH)D3] on the Th17 response was mediated via both T cells and DCs. DCs pathway is involved in the direct inhibition of 25(OH)D3 on Th17 cell differentiation in young asthmatics. © 2014 Elsevier GmbH. Source

Lagha A.,Salah Azaiez Institute | Chraiet N.,Salah Azaiez Institute | Labidi S.,Abderrahman Mami Hospital | Rifi H.,Salah Azaiez Institute | And 8 more authors.
Critical Reviews in Oncology/Hematology | Year: 2013

The concept of larynx preservation in locally advanced laryngeal or hypopharyngeal squamous cell carcinoma has evolved during the last three decades, especially with the advancement of nonsurgical strategies. These nonsurgical strategies include: (1) radiotherapy alone; (2) concomitant chemoradiotherapy (CCRT); and (3) induction chemotherapy followed by radiotherapy or CCRT and concurrent anti-epidermal growth factor receptor (EGFR). To date, the best approach for larynx preservation has yet to be defined. In this article, we review and discuss important recent randomized phase II/III trials investigating larynx preservation in order to facilitate the selection of an appropriate strategy in the clinical setting. However, the decision of larynx preservation should always be a multidisciplinary approach. © 2013 Elsevier Ireland Ltd. Source

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