PubMed | Eli Lilly and Company, Lilly Research Laboratories, Pfizer, University of Heidelberg and 8 more.
Type: Journal Article | Journal: Nature reviews. Drug discovery | Year: 2016
Despite the vast amount of research on schizophrenia and depression in the past two decades, there have been few innovative drugs to treat these disorders. Precompetitive research collaborations between companies and academic groups can help tackle this innovation deficit, as illustrated by the achievements of the IMI-NEWMEDS consortium.
Abbvie Deutschland Gmbh &Co. Kg and Abbvie Inc. | Date: 2013-03-14
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula (I) in which R^(1), R^(2 )and n have the meanings mentioned in the claims and the description, Y is a radical of the formulae (Y1) or (Y2) where # indicates the point of attachment of Y to the pyridine ring, R^(3), R^(4), R^(5), R^(y )and m have the meanings mentioned in the claims and the description, A is (CH_(2))_(p )with p being 1, 2, 3 or 4, where one or two hydrogen atoms may be replaced by a radical R^(6), where A is attached to the 3- or 4-position of the pyrazole radical and R^(6 )has the meaning mentioned in the claims and the description; A^(1 )is (CH_(2))q with q being 0, 1, 2 or 3, where one or two hydrogen atoms may be replaced by halogen or C_(1)-C_(4)-alkyl; and A^(2 )is (CH_(2))r with r being 0, 1, 2 or 3, where one or two hydrogen atoms may be replaced by halogen or C_(1)-C_(4)-alkyl, provided that that r+q is 2, 3, 4, 5 or 6; their tautomers, the hydrates thereof, the pharmaceutically suitable salts of the carbox-amide compounds (I), the prodrugs of (I) and the pharmaceutically suitable salts of the prodrugs, tautomers or hydrates of (I).