AB Enzymes GmbH

Darmstadt, Germany

AB Enzymes GmbH

Darmstadt, Germany
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News Article | July 11, 2017
Site: www.prweb.com

Genedata, a leading provider of advanced software solutions for R&D, today announced that it has expanded its partnership with AB Enzymes, one of the world’s oldest and most well-known enzyme manufacturers. AB Enzymes, partnering with Genedata since 2013, uses Genedata Selector™ as its bioinformatics platform for strain genome data management on all of its production-relevant organisms. Building on this, AB Enzymes will now utilize Genedata Selector for decision support on production strain optimization and strain compliance assessment processes. “Over the past three years, we have learned a lot about the genomic background of our production strains and, as a result, have been able to enhance their performance thanks, in part, to Genedata Selector,” stated Dr. Jari Vehmaanperä, global R&D director at AB Enzymes. “With the software’s latest developments, we now plan to utilize Genedata Selector in our investigations of new enzymes and in assessing the compliance requirements of our production strains.” Genedata Selector was originally implemented as a centralized data management system that allowed for sharing of genomic data across AB Enzymes’ globally distributed R&D organizations. The software allowed for integration of AB Enzymes’ existing genomic data with transcriptomics and metabolomics data improving gene functional annotation and providing insights into molecular pathways. The Selector solution was initially hosted by Genedata in a private cloud setup allowing AB Enzymes to minimize their startup costs and fast-track their projects. As their usage and amount of data increased, AB Enzymes invested in local infrastructure and now operates the enterprise software platform from in house while still taking advantage of Genedata’s scientific consulting services. The latest version of Genedata Selector provides new functionalities that analyze and manage NGS data for reliable strain compliance assessment and for investigating microbiome communities. Automated workflows allow for efficient and reproducible analyses of NGS data for specific assessment of strain compliance while Genedata Selector’s new metagenomics processing pipeline allows for unique integrations of functionally annotated metagenomes. With these new functionalities, customers like AB Enzymes are able to investigate datasets more effectively for new enzyme candidates and feel confident in their assessment of strain compliance. This combined with AB Enzymes’ accumulated genome knowledge will allow the scaling up of their R&D pipeline and optimize downstream processes thereby reducing the time between product development and registration. “We are very excited about the expansion of the collaboration between Genedata and AB Enzymes and their endeavors into genomic diversity and strain compliance assessment,” said Dr. Othmar Pfannes, CEO of Genedata. “Genedata will continue to invest in areas of interest that are important to our customers to provide them the most cutting-edge technology and bioinformatics support. Our goal is to enable our customers, like AB Enzymes, to improve their efficiencies and thus reduce their costs so they can become even more successful.” On top of providing innovative insights into production organisms, Genedata Selector streamlines R&D processes, thereby cutting costs and reducing development times. Genedata Selector’s integrated approach to global knowledge management facilitates collaboration among research groups and sites, with easy access to all data under one umbrella system. Editorial Note: BIO World Congress on Industrial Biotechnology Date: July 23-26, 2017 Montréal, Canada Meet Genedata experts at the BIO World Congress in Montréal, Canada. Learn how Genedata Selector can help improve your strain management processes. About Genedata Genedata transforms data into intelligence with innovative software solutions and domain-specific consulting services that automate complex, large-scale experimental processes and enable organizations to maximize the ROI from their R&D. Founded in 1997, Genedata is headquartered in Switzerland and has offices in Germany, the UK, Japan, and the US. http://www.genedata.com Follow Us on LinkedIn About AB Enzymes AB Enzymes is an industrial biotech company specializing in enzymes and their applications. Since 1907, AB Enzymes has been developing, manufacturing and supplying enzymes for baking, beverages, grains and vegetable oil seeds processing, animal feed and technical applications such as pulp and paper, textiles and laundry detergents. The company is part of Associated British Foods and is represented worldwide with offices located in Darmstadt, Rajamäki, Fort Lauderdale, Sao Paulo, Singapore and Shanghai, with manufacturing at partner ROAL in Rajamäki, Finland. http://www.abenzymes.com/ Disclaimer The statements in this press release that relate to future plans, events or performance are forward-looking statements that involve risks and uncertainties, including risks associated with uncertainties related to contract cancellations, developing risks, competitive factors, uncertainties pertaining to customer orders, demand for products and services, development of markets for the Company's products and services. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. The Company undertakes no obligation to release publicly the result of any revisions to these forward-looking statements that may be made to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. All product and service names mentioned are the trademarks of their respective companies.


Grant
Agency: European Commission | Branch: H2020 | Program: BBI-RIA | Phase: BBI.VC2.R6-2015 | Award Amount: 3.66M | Year: 2016

The main objective of NeoCel project is to develop innovative and techno-economically feasible alkaline processes enabling the sustainable production of higher quality eco-innovative textile fibres from reactive high-cellulose pulps and integration of these processes with pulp mills. Targets for the development of NeoCel processes are: - wet strength of fibres higher than the wet strength of standard viscose, competing with cotton properties. - lower environmental impact than any other type of existing textile fibre - Reduction of production cost by at least 15% compared to that of best available technology (BAT) viscose The targets will be met through development of adapted pulps with high reactivity/solubility in alkaline water-based solutions, advanced dissolution process to maximize cellulose concentration, novel cellulose regeneration chemistry enabling both recovery of process chemicals and increased strength properties of the spun fibre, design for integration of textile fibre production with the pulp mill for minimized environmental impact, increased energy efficiency and reduced chemical consumption through system analysis using software models of theoretical mills. In NeoCel, a consortium with raw material processing companies, chemical suppliers, equipment producers, SMEs and world-leading research institutes has formed to develop the processes for large scale manufacturing of eco-innovative textile fibres. The consortium expects that a successful NeoCel project will enable creation of 75 000 new jobs and a turn-over increase of 9.5 billion for European forest products, textile and clothing industries within 15 years. However, already within 3 years, the consortium partners expect their joint turnover to increase by 170 MEuro


Grant
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENERGY.2008.3.2.2 | Award Amount: 16.26M | Year: 2010

The EC Directives set ambitious targets for mandatory 10 % biofuels share in road transport. 2nd generation biofuels will give significant benefits as ethanol blends in gasoline and synthetic biodiesel products. The innovative focus in the FibreEtOH project is to demonstrate for the first time globally in a commercial scale, a cost efficient paper fibre based ethanol production with high, > 70 % overall energy efficiency with high > 50 % green house gas reduction. 2nd generation ethanol production technology has been developed using mainly corn stover, straw or saw dust as raw material. So far reliable and cost efficient hydrolysis technology has been the bottleneck for large scale commercial success. By using paper fibres separated from commercial and municipal solid waste or de-inking sludge at paper mills, the hydrolysis process will be significantly easier as no pretreatment and special fractionation process is needed. It is estimated that such raw material is available in quantities for more than one million t/a ethanol production capacity. The EtOH production cost will be highly attractive due to the low price of the waste based raw material and the distillation steam compared to typical straw and wood EtOH production plants. The proposed demonstration plan with 20 000 m3/a ethanol production capacity will be build using 250 000 t/a waste from Helsinki metropolitan area in Finland. Biogas, district heat and electricity will be produced from the by-products. The site and environmental permits have already been granted. The ethanol will be used in Finland in dedicated E5 E85 blends optimising the ethanol fuels to cold climate conditions and tail pipe emissions reduction. The FibreEtOH-proposal will demonstrate innovations in a novel 2G EtOH production chain using optimized and cost-effective enzymatic hydrolysis process taking advantage of the adjacent enzyme production and the whole production concept with high overall process integration.


Grant
Agency: European Commission | Branch: H2020 | Program: BBI-RIA | Phase: BBI.VC3.R7 | Award Amount: 3.10M | Year: 2015

There is a global need, from sustainability, food security and also health perspective, to increase dietary intake of plant protein. Side-streams from wheat and rice processing offer large under-exploited raw material potential, and we will work throughout the agro-industrial value chain to valorise that. The main aim of PROMINENT is to develop techno-economically and environmentally viable protein-based ingredients and foods from cereal processing side streams. We will concentrate on novel fractionation and extraction technologies, such as bioprocessing, supercritical carbon dioxide (SC-CO2) -extraction, thermo-mechanical technologies, wet and dry fractionation, and expanded bed adsorption as well as their combinations as novel hybrid processing technologies. A strong focus will be in using enzymatic and thermo-mechanical methods to improve techno-functional and sensory properties of protein ingredients to reach desirable taste and texture in food applications. Pasta, biscuit, cake and beverage food models are the main end product categories, where new protein ingredients will be used as dietary protein source and act as performance proteins to deliver similar techno-functional and sensory properties to animal proteins. We will also assess the safety, quality, techno-economical feasibility, sustainability and market potential of the new protein ingredients and foods, and design strategies for marketing, dissemination, and exploitation of innovations. The project will support the economic growth, resource efficiency and sustainability of the European agro-food industry, and open new market opportunities by generating new plant protein ingredients obtained from cereal processing side streams as well as new products for the consumer food market.


Patent
AB Enzymes GmbH | Date: 2013-01-23

The invention relates to the use of a composition comprising at least one polypeptide having glucoamylase activity and optionally at least one polypeptide having -1,3-endoglucanase activity in a process of lysing yeast cell walls as well as to a process for lysing yeast cell walls which comprises exposing said yeast cell walls to a composition comprising at least one polypeptide having glucoamylase activity and optionally at least one polypeptide having -1,3-endoglucanase activity.


The invention relates to a recombinant DNA molecule encoding a polypeptide having phytase activity and increased temperature stability and increased proteolytic stability of the enzyme activity. The DNA sequence has been obtained by variation of the mature wild-type E. coli phytase sequence with defined amino acid positions being modified in comparison to the wild-type sequence or with the sequences having N- and/or C-terminal extensions, respectively. The invention further relates to a method for expressing the recombinant phytase as well as its use in the food and animal feed technologies.


The invention relates to a process for identifying gene(s)/genetic element(s) associated with mating impairment in strains of Trichoderma reesei QM6a or strains derived thereof comprising the steps of a) providing a first strain being a Trichoderma reesei QM6a strain having a MAT1-2 locus or a strain derived thereof, b) sexually crossing said strain with a second strain being a mating competent strain of a Trichoderma reesei (Hypocrea jecorina) strain having a complementary locus, i.e. the MAT1-1 locus, c) repeatedly back-crossing the MAT1-1 progenies from the crossing of b) or the back-crossing thereof with the first strain of a), until a strain is obtained that is substantially identical to the first Trichoderma reesei QM6a strain or a strain derived thereof, but carries the MAT1-1 locus and is mating competent for crossing with Trichoderma reesei QM6a or any of its MAT1-2 progeny, d) selecting the progeny from step c) that is mating competent for crossing with a Trichoderma reesei (Hypocrea jecorina) having a MAT1-2 locus, and e) identifying the gene(s)/genetic element(s) associated with mating impairment by comparing the genome of the progenies selected in step d) with the genome sequences of the first strain of a) whereby said gene(s)/genetic element(s) may be fully or partially missing or existing in a mutated form or in a form having deletions or insertions in the first strain thus being a gene or a genetic element directly or indirectly associated with mating impairment in strains of Trichoderma reesei QM6a or a strain derived thereof as well as to a process for correcting the mating impairment of a Trichoderma reesei QM6a strain or a strain derived thereof having a MAT1-1 locus and that is not competent to mate with a Trichoderma reesei QM6a strain having a MAT1-2 locus or a strain derived thereof, wherein one or more mutated or fully or partially missing gene(s) and/or genetic element(s) identified as above is/are replaced by or complemented with the corresponding functional gene(s) and/or genetic element(s). Moreover, the invention relates to the use of a thus obtained fungal strain of the genus Trichoderma in industrial breeding and production of a product of interest. Moreover, the invention relates to the genes associated with mating impairment of Trichoderma reesei QM6a and strains derived therefrom and to genes essential for mating of Trichoderma reesei QM6a and strains derived therefrom.


Patent
AB Enzymes GmbH | Date: 2014-10-08

The invention relates to the use of a composition comprising at least one polypeptide having glucoamylase activity and optionally at least one polypeptide having -1,3-endoglucanase activity in a process of lysing yeast cell walls as well as to a process for lysing yeast cell walls which comprises exposing said yeast cell walls to a composition comprising at least one polypeptide having glucoamylase activity and optionally at least one polypeptide having -1,3-endoglucanase activity.


Patent
AB Enzymes GmbH | Date: 2012-05-10

The invention relates to a DNA sequence that encodes a polypeptide with lysophospholipase activity and was isolated from Aspergillus and sequences derived therefrom, polypeptides with lysophospholipase activity encoded by these sequences as well as the use of these polypeptides for improving the filterability of syrups consisting of wheat starch and for related applications.


Patent
AB Enzymes GmbH | Date: 2015-04-21

The invention relates to a DNA sequence, which codes for a polypeptide having phospholipase activity essentially without lipase activity, characterized in that the DNA sequence is selected from a) DNA sequences that comprise a nucleotide sequence according to SEQ ID NO: 1, b) DNA sequences that comprise the coding sequence according to SEQ ID NO: 1, c) DNA sequences that code for the protein sequence according to SEQ ID NO: 2, d) DNA sequences that are coded for by the plasmid pPL3940-Topo2.5 with the restriction map according to FIG. 7, which is deposited under accession number DSM 22741, e) DNA sequences that hybridize under stringent conditions with one of the DNA sequences according to a), b), c) or d), f) DNA sequences that are related to the DNA sequences according to a), b), c), d) or e) due to the degeneration of the genetic code, and g) complementary strands to the sequences according to a) to f), wherein the DNA sequence is preferably derived from Aspergillus, and more preferably from Aspergillus fumigatus, and a polypeptide having phospholipase activity essentially without lipase activity selected from a) a polypeptide which is coded for by the coding part of a DNA sequence as defined above, b) a polypeptide having the sequence according to SEQ ID NO: 2 or a sequence derived therefrom, which may be obtained by substitution, addition, deletion of one or more amino acid(s), c) a polypeptide having a sequence that has at least 83% identity with the amino acids 1 to 299 of SEQ ID NO: 2, d) a polypeptide which is coded for by a nucleic acid sequence which hybridizes under stringent conditions with (i) nucleotides 55 to 1106 of SEQ ID NO: 1, (ii) the cDNA sequence contained in nucleotides 55 to 1106 of SEQ ID NO: 1, (iii) a partial sequence of (i) or (ii) composed of at least 100 nucleotides, or (iv) a complementary strand of (i), (ii) or (iii), e) a variant of the polypeptide having SEQ ID NO: 2, comprising a substitution, deletion and/or insertion of one or more amino acid(s), f) allelic variants to amino acid sequences a) to e).

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