Aarupadai Veedu Medical College

Puducherry, India

Aarupadai Veedu Medical College

Puducherry, India
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Yusuf J.H.,SRM University | Kaliyaperumal D.,Aarupadai Veedu Medical College | Jayaraman M.,SRM University | Ramanathan G.,Sri Ramachandra University | Devaraju P.,SRM University
Lupus | Year: 2017

Objectives Lupus is a classical systemic autoimmune disease with genetics as one of the well known causative factors for the disease pathogenesis. Toll-like receptors are the major pattern recognition receptors associated with innate immunity and also act as an interface with the adaptive immunity. Genetic polymorphisms in genes encoding TLRs were implicated in the development of infections, malignancies and autoimmune diseases. TLR9 is a member of TLR family, and recognizes the CpG DNA motifs of pathogens. Though the incidence rate of lupus in Asians was reported to be low (30 -' 50/100,000 population), poor disease prognosis due to higher incidence of renal complications and aggressive disease worsens the scenario. The ability of TLR9 to detect and elicit an immune response against double-stranded DNA makes TLR9 a relevant factor to be tested for its association with the clinical and serological phenotypes of lupus. However, lack of relevant genetic data on normative frequencies of the TLR9 (rs187084) polymorphism may serve as a constraint to derive the sample size to conduct case control association studies. Hence this study was conducted to establish the normative frequency of TLR9 (rs187084) polymorphism in Indian Tamils. Materials and methods The TLR9 (rs187084) polymorphism was screened in South Indian Tamils (n = 208) by PCR-RFLP. Results and discussion We observed a higher occurrence of the mutant allele (65%) in South Indian Tamils. No gender disparity with respect to the mutant allele frequency was observed. The higher incidence of mutant allele in both genders suggests that this population had undergone a genetic selection pressure as an evolutionary genetic measure to withstand the prevailing endemic infections like TB and malaria. Though the enhanced expression of TLR9 was protective against infections, it may also influence the development of autoimmune diseases. Conclusion The higher incidence of theTLR9 (rs187084) over-expression mutation in Indian Tamils is suggestive of a genetic adaptation or selection pressure to withstand the prevailing endemic infectious and parasitic diseases. However, this genetic adaptation poses a greater risk to develop autoimmune diseases like SLE etc through complex gene environment interactions. The normative frequency of the TLR9 (rs187084) polymorphism established in our population could now be used to define the sample size for future case control studies. © The Author(s), 2016.


Oudeacoumar P.,Aarupadai Veedu Medical College
Indian Journal of Dermatology | Year: 2012

Congenital insensitivity to pain with anhidrosis, also known as hereditary sensory and autonomic neuropathy type IV, is an autosomal recessive disorder characterized by the congenital lack of pain sensation, inability to sweat, episodes of recurrent hyperpyrexia, mental retardation, and self-mutilating behavior. It is an extremely rare disorder with only a handful of reports from India. A five- year- old boy, born to second-degree consanguineous parents after uneventful antenatal period, presented to us with history of recurrent unexplained fever, recurrent ulcers in the lower limbs, insensitivity to painful stimuli (like injections, vaccination) and self-mutilating behavior from early childhood. Cutaneous examination showed multiple ulcers, loss of teeth, loss of tip of the tongue (due to biting), scarring of finger tips, xerosis and lichenification. Sensory examination showed complete loss of pain and temperature sensations, but fine touch and vibration were preserved. Deep tendon reflexes were normal. Evaluation for Hansen's disease was non-contributory. An intradermal injection of histamine did not show any flare response. Based on clinical as well as compatible histological features a diagnosis of congenital insensitivity to pain with anhidrosis was made. The ulcers were treated with appropriate antibiotics and daily dressings. The parents were counseled about appropriate care of the child.


Ramaswamy S.,Sri Lakshminarayana Institute of Medical science | Jaikumar S.,Aarupadai Veedu Medical College
International Journal of Pharma and Bio Sciences | Year: 2010

Trachyspermum ammi fruit have traditionally been used in India as medicinal plant for the treatment of indigestion and dyspepsia and many other gastric disorders. In the present study ethanolic extract of Trachyspermum ammi fruit was used for investigation of antiulcer activity by using pylorus ligation, as antisecretary model and Indomethacin induced ulcer model, ethanol induced ulceration model, cold restraint stress induced ulcer model as cytoprotective model. Animals pretreated with ethanolic extract of Trachyspermum ammi fruit at the dose 100mg/kg and 200mg/kg showed significant decrease in ulcer index and percentage ulcer protection in all models. The results suggests that the extract at 100mg/kg and 200mg/kg showed significant protection (p<0.001) by reducing ulcerative lesions when compared with control group of animals. These findings indicate that Trachyspermum ammi fruit extract shows significant antiulcer activity.


Jaikumar S.,Sri Lakshminarayana Institute of Medical science | Ramaswamy S.,Sri Lakshminarayana Institute of Medical science | Asokan B.R.,Aarupadai Veedu Medical College | Mohan T.,Aarupadai Veedu Medical College | Gnanavel M.,Shasun Chemicals and Drugs Ltd.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

This study has been undertaken to investigate the effect of methanolic extract of leaves of Jatropha curcas Linn. (JC) on pylorus ligation and Aspirin-induced gastric ulcers in Wistar rats. 30 albino wistar rats of either sex were selected and divided into 5 groups of 6 animals each. Gastric lesions produced by pylorus ligation (PL) plus aspirin (200mg/Kg, PO). Treatment with JC extract of (100 mg/Kg bodyweight, 200 mg /Kg body weight) and ranitidine (50 mg/Kg body weight) for 6 days to the aspirin and PL rats were given and absorb the acid parameters.A significant dose dependant reduction (P < 0.05) in the acid parameters like gastric volume, pH, total acidity, total acid output, total proteins and ulcer index were observed after treatment with 100 mg, 200 mg JC extracts in PL plus aspirin induced ulcers compared to the normal PL rats. Histopathological examination of stomach mucosa showed the protective action of JC extracts against mucosal epithelial damage caused by aspirin. The present study provides a strong evidence of antiulcer activity of JC extract against gastric lesions. The antiulcer activity is recognized by a reduction in acid-secretary parameters (i.e. total and free acid), gastric volume and ulcer score suggesting that acid inhibition accelerates ulcer healing, thereby strengthening of mucosal barrier.


Bhat M.A.,Indira Gandhi Medical College and Research Institute | Sageerabanoo S.,Aarupadai Veedu Medical College | Kowsalya R.,Institute of Nephrourology | Sarkar G.,Subharathi Medical College
Journal of Clinical and Diagnostic Research | Year: 2012

Introduction: The Extended Spectrum Beta Lactamases (ESBLs) are the class A plasmid mediated enzymes that hydrolyze the oxyimino-cephalosporins and the monobactams but not the cephamycins and they are inhibited by clavulanic acid. In the recent years, the CTX-M type are the most common ESBLs which have been isolated. The present study was undertaken to know the prevalence of the ESBL producing E. coli in urinary tract infections (UTIs) and also to know the occurrence of the CTX-M3 genotype among these E. coli which were isolated in our hospital. Materials and Methods: The routine antimicrobial susceptibility testing was done for the E. coli which were isolated from the urine samples. The strains of E. coli that were resistant to cefotaxime and ceftriaxone were selected for the ESBL testing. The strains were tested for ESBL production by the Double Disc Synergy Test (DDST) and the phenotypic confirmatory double disc test (PCDDT) as per the CLSI guidelines. Fifty four isolates of E. coli were found to be positive for ESBL by the phenotypic methods, out of which fifty isolates were tested for the presence of CTX-M3 by PCR and also their minimum inhibitory concentrations (MICs) for ceftazidime were determined. Results: Out of a total of 157 E. coli isolates, 54 isolates (34.4%) were found to be positive for ESBL by the phenotypic methods, DDST and PCDDT. Nearly 21(38.8%) ESBL positive E. coli isolates had an MIC of ≥ 128μg/ml for ceftazidime. Out of the 50 strains of ESBL positive E. coli that were run for PCR, 42(84%) were positive for the CTX-M3 gene. Conclusion: Our study showed that the ESBL producing urinary isolates of E. coli were not only resistant to the third generation cephalosporins but also to ciprofloxacin, cotrimoxazole and gentamicin. The occurrence of the CTX-M3 genotype was high among the E. coli isolates in our study.


Geethalakshmi S.,Aarupadai Veedu Medical College | Geethalakshmi S.,Government Stanley Medical College Hospital | Narendrakumar V.,Madras Medical College and Rajiv Gandhi Government General Hospital
Journal of Clinical and Diagnostic Research | Year: 2015

Perrault syndrome is a rare disease comprising pure gonadal dysgenesis (46 XX) and sensorineural hearing loss in females and deafness alone in affected males. It is an autosomal recessive disorder. Over the years many additional features like marfanoid habitus and central nervous system findings have also been reported. Herein we report a case of sporadic Perrault syndrome in 18-year-old female who presented to our hospital with deaf mutism and primary amenorrhoea. On evaluation, the patient had hypergonadotropic hypogonadism, streak gonads and a normal karyotype (46 XX). Audiologic evaluation showed sensorineural deafness. The patient was started on hormone replacement therapy. She is on regular follow up. We present this case for its infrequent incidence and also to add to the ever expanding clinical spectrum of this disease. © 2015, Journal of Clinical and Diagnostic Research. All Rights Reserved.


Potdar P.A.,Aarupadai Veedu Medical College | Raikar V.R.,Aarupadai Veedu Medical College | Potdar A.B.,Aarupadai Veedu Medical College
Indian Journal of Public Health Research and Development | Year: 2015

Family planning is being recognized as one of the most important issues not only as in population number problems but as an issue which affects the health and lives of women and children. The increased use of contraception is indisputably the main proximate determinant of the fertility decline and a factor that improves quality of life of a woman and her baby. Objectives: To find out the socio-demographic determinants and magnitude of current contraceptive use among married women residing in urban area of Bagalkot,North Karnataka. Methodology: House to house survey by interview method by administering a pre-designed, structured questionnaire. Study Population: Married women in the reproductive age group (15-44 years). Study Design: Cross sectional Study. Study Period: 1st June 2010 to 31st May 2011. Results: The prevalence of contraceptive use was found to be 58.05% in the study area. Around 3/4th of the subjects i.e. 72.28% adopted tubectomy as method of contraception. None of the respondents had opted for vasectomy as contraceptive measure. Temporary methods were followed by 27.72% of current contraceptive users. Contraceptive acceptance was more in women who are graduate and above (95.45%), women from a nuclear family (62.38%), upper middle socioeconomic class (81.46%). Significant association was found between contraceptive acceptance and literacy status, occupation, type of family, socioeconomic status and age at marriage. Temporary contraception was better accepted by those females who were educated upto high school and above, among those who were occupied in skilled and above occupation. Conclusion: There is urgent need to increase awareness about contraceptive use in the society with special emphasis on involvement of male partners. © 2015, Indian Journal of Public Health Research & Development. All rights reserved.


Kone K.,Aarupadai Veedu Medical College
Indian Journal of Urology | Year: 2014

Ovarian vein syndrome is defined as obstructive uropathy caused by dilated ovarian vein with or without thrombosis. This is seen in the puerperal period as an acute condition with abdominal pain and fever and in multipara women with chronic recurrent abdominal pain. We report an ovarian vein syndrome caused by a true vascular anomaly in an 8-year-old child. Laparoscopic ureterolysis was performed with ligation of the arteriovenous malformation during the first operation. As ureterolysis was not effective, the patient was reoperated and ureteroureterostomy was performed after 3 months, which emphasizes the importance of removing the diseased segment even if it looks normal.


PubMed | Sri Manakula Vinayagar Medical College, Aarupadai Veedu Medical College, Government of Puducherry and Dhanalakshmi Srinivasan Medical College
Type: Journal Article | Journal: Journal of natural science, biology, and medicine | Year: 2015

Production of -lactamase enzymes by Gram-negative bacteria is the most common mechanism to acquire drug resistance to -lactam antibiotics. Limitations in detecting extended spectrum -lactamases (ESBL) and Amp-C -lactamases have contributed to the uncontrolled spread of bacterial resistance and are of significant clinical concern.A total of 148 samples was selected on the basis of resistance against third-generation cephalosporin for screening ESBLs and Amp-C -lactamases production. These multidrug-resistant strains were phenotypically screened for ESBL production by phenotypic confirmatory disc diffusion test and double disc synergy test. Modified three-dimensional method was used for Amp-C -lactamases detection.Among the 148 isolates, 82 (55.40%) were ESBL producers, and 115 (77.70%) were Amp-C -lactamases producers. Co-existence of ESBL and Amp-C was observed in 70 (47.29%) isolates. Escherichia coli was the most common ESBL and Amp-C -lactamase producer. All ESBL producers were highly resistant to ciprofloxacin (83.10%), cotrimoxazole (95.27%), and gentamicin (89.18%). However, these bacterial strains were sensitive to imipenem 146 (98.64%) and piperacillin/tazobactam 143 (96.62%).Our study showed that ESBL producing organisms were not only resistant to cephalosporins but also to other group of drugs and also that multiple mechanisms play a role in drug resistance among Gram-negative bacteria.


PubMed | Aarupadai Veedu Medical College
Type: Journal Article | Journal: Indian journal of urology : IJU : journal of the Urological Society of India | Year: 2014

Ovarian vein syndrome is defined as obstructive uropathy caused by dilated ovarian vein with or without thrombosis. This is seen in the puerperal period as an acute condition with abdominal pain and fever and in multipara women with chronic recurrent abdominal pain. We report an ovarian vein syndrome caused by a true vascular anomaly in an 8-year-old child. Laparoscopic ureterolysis was performed with ligation of the arteriovenous malformation during the first operation. As ureterolysis was not effective, the patient was reoperated and ureteroureterostomy was performed after 3 months, which emphasizes the importance of removing the diseased segment even if it looks normal.

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