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Takenaga S.,Aachen University Of Applied Sciencesheinrich Mussmann Str152428Julichgermany | Schneider B.,Aachen University Of Applied Sciencesheinrich Mussmann Str152428Julichgermany | Erbay E.,Aachen University Of Applied Sciencesheinrich Mussmann Str152428Julichgermany | Biselli M.,Aachen University Of Applied Sciencesheinrich Mussmann Str152428Julichgermany | And 3 more authors.
Physica Status Solidi (A) Applications and Materials Science | Year: 2015

A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

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