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Globa A.G.,Russian Academy of Agricultural Sciences | Alekseev I.Ya.,Russian Academy of Agricultural Sciences | Varlamov D.A.,Russian Academy of Agricultural Sciences | Vishnevsky A.A.,Vishnevsky Institute of Surgery
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry | Year: 2012

The levels of the RNA oncomarkers, telomerase (hTERT), cytokeratin-19 (CK-19), and mammaglobin (MAM) have been investigated in capillary blood of female patients with mammary ductal carcinoma. The study revealed overexpression of all three factors in patients with this pathology. This overexpression was not found in healthy donors and female patients with mammary fibroadenoma. Levels of the RNA oncomarkers return to the normal level within 10 days after successful tumor resection. These results have been used for the development of diagnostic kits, which may be applicable for differential diagnostics, screening and postoperation monitoring of patients with malignant breast tumors. © 2012 Pleiades Publishing, Ltd.

Sergeev I.K.,Opticheskie Sistemy i Tekhnologii Ltd. | Sterlin U.G.,Yalamov Urals Optical and Mechanical Plant | Subbotin V.V.,Vishnevsky Institute of Surgery
Biomedical Engineering | Year: 2013

Development of anesthetic equipment for contemporary hospitals is urgently needed. Use of modular design provides a more flexible approach to supplying surgical centers and municipal hospitals with effective anesthetic equipment. © 2013 Springer Science+Business Media New York.

Kondratyev E.,Vishnevsky Institute of Surgery | Karmazanovsky G.,Vishnevsky Institute of Surgery
European Journal of Radiology | Year: 2013

To evaluate the effect of hybrid iterative reconstruction on qualitative and quantitative parameters atlow dose carotid CTA.Materials and methods: 44 consecutive patients were enrolled in the study. First group (n = 22) was exam-ined under 120 kV 250 mAs, second group (n = 22) - 100 kV 250 mAs. CT images in first group werereconstructed only with the filtered back projection (FBP). CT data in second group were reconstructedboth with FBP and three levels of hybrid iterative reconstruction algorithm (iDose). We compared quan-titative and qualitative parameters among the two groups and among four different reconstructions insecond group.Results: Effective dose in 120 kV and 100 kV group was 7.18 ± 1.19 mSv and 4.14 ± 1.03 mSv, respec-tively (p < 0.0001). Mean arterial attenuation was about 25% higher in second group (236.5 ± 46 HU vs.302.6 ± 32.7 HU; p < 0.0001). Image noise at the level of humeral belt was 32.5 ± 12.5 in 100 kV group and26.3 ± 13.3 in 120 kV (p = 0.115).Average noise decreased when using 3 levels of iDose up to 23.6 ± 6.4, 17.7 ± 5.6 and 13.7 ± 5.1,respectively (p = 0.00001). Mean CNR increased to 10.38 ± 3.87, 14.5 ± 5.21 and 18.32 ± 8.61, respectively(p < 0.05).The presence of artifacts on the level of humeral belt in 120 kV group was 14%, in 100 kV - 41%(p = 0.002). The difference in visual scores between standard and low-dose protocol was significant(p = 0.008). When applying iterative reconstruction the frequency of streak artifacts decreased dramati-cally (p < 0.0001). Most studies had excellent quality with no artifacts while using highest level of iDose.Conclusion: According to the results of our study low dose CT angiography using hybrid iterative recon-struction may provide sufficient image quality and allows for significant reduction of patient dose. © 2013 Elsevier Ireland Ltd. All rights reserved.

Tumanova U.N.,Vishnevsky Institute of Surgery | Karmazanovsky G.G.,Vishnevsky Institute of Surgery
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk | Year: 2013

Objective: A comparative analysis of the degree of vascularization of hepatocellular carcinoma (HCC) and focal nodular hyperplasia (FNG) of the liver at carrying out multislice computed tomography (MCT) and morphological studies. Patients and methods: 34 patients operated on for HCC (19 patients) and FNG of liver (15 patients) were survey. Preoperative we were analyzed four phases of CT-research: native, arterial, venous, delayed. Degree of vascularization of tissue were evaluated for immunohistochemical preparations on the relative share of the area of blood vessels. Results: In native phase of the MCT-study HCC was detected as hypodense or izodensnoe education. Growth of the blood CT density depend on the type and extent of tumor histological differentiation of cancer. The highest values are set in the fabric of FNG and moderately differentiated HCC . The highest levels of venous growth observed in well differentiated HCC. Indicators of vascularization by CT have maximum values in the unaffected liver parenchyma , and the minimum - in the group of poorly differentiated HCC variant. Conclusions: Use of computed tomography with bolus contrast enhancement allows to study the characteristics of blood supply of the liver and focal formations. Frequently only the use of this method helps to evaluate specific morphological structure of tumors - hepatocellular carcinoma or focal nodular hyperplasia. As an additional differential diagnostic feature is recommended to increase the density determination of tissue formation in the arterial phase computed tomography study. The maximum of vascularization by computed tomography and immunohistochemistry (with antibodies CD34) are installed in a tissue of highly differentiated hepatocellular carcinoma.

Egorov V.I.,Moscow State University | Vankovich A.N.,Vishnevsky Institute of Surgery | Petrov R.V.,Moscow State University | Starostina N.S.,Moscow State University | And 3 more authors.
BioMed Research International | Year: 2014

Background. The term "paraduodenal pancreatitis" (PP) was proposed as a synonym for duodenal dystrophy (DD) and groove pancreatitis, but it is still unclear what organ PP originates from and how to treat it properly. Objective. To assess the results of different types of treatment for PP. Method. Prospective analysis of 62 cases of PP (2004-2013) with histopathology of 40 specimens was performed; clinical presentation was assessed and the results of treatment were recorded. Results. Preoperative diagnosis was correct in all the cases except one (1.9%). Patients presented with abdominal pain (100%), weight loss (76%), vomiting (30%), and jaundice (18%). CT, MRI, and endoUS were the most useful diagnostic modalities. Ten patients were treated conservatively, 24 underwent pancreaticoduodenectomies (PD), pancreatico- and cystoenterostomies (8), Nakao procedures (5), duodenum-preserving pancreatic head resections (5), and 10 pancreas-preserving duodenal resections (PPDR) without mortality. Full pain control was achieved after PPRDs in 83%, after PDs in 85%, and after PPPH resections and draining procedures in 18% of cases. Diabetes mellitus developed thrice after PD. Conclusions. PD is the main surgical option for PP treatment at present; early diagnosis makes PPDR the treatment of choice for PP; efficacy of PPDR for DD treatment provides proof that so-called PP is an entity of duodenal, but not "paraduodenal," origin. © 2014 V. I. Egorov et al.

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