Silachev D.N.,A N Belozersky Institute Of Physical And Chemical Biology |
Plotnikov E.Y.,A N Belozersky Institute Of Physical And Chemical Biology |
Babenko V.A.,lakov Research Center For Obstetrics |
Zorova L.D.,Moscow State University |
And 5 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2016
Here we studied the cytoprotective effect of lithium chloride and sodium valproate in the in vivo model of neonatal cerebral ischemia/hypoxia and analyzed the influence of these substances on the death of the major neurovascular unit components in experimental ischemia in vitro. Lithium chloride and sodium valproate effectively prevented death of neurons, astrocytes, and endothelial cells in the oxygen-glucose deprivation. This treatment protected the brain of newborn rats from ischemia/hypoxia injury. The results suggest that lithium and sodium valproate can be used for the treatment of neurodegenerative pathologies associated with hypoxia and ischemia in newborns. © 2016 Springer Science+Business Media New York