Blanco-Calvo M.,La Coruna Biomedical Research Institute INIBIC |
Tarrio N.,Santander University |
Reboredo M.,University of La Coruna |
Haz-Conde M.,La Coruna Biomedical Research Institute INIBIC |
And 8 more authors.
Future Oncology | Year: 2014
Aim: To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also analyzed. Patients & methods: Fifty-two GC and 23 control samples were included. Results: GDF15 and MMP7 proved to be powerful tools for GC diagnosis. Increased levels of GDF15 and MMP7 were associated with shorter progression-free survival and overall survival in univariate analysis. In multivariate analysis, the combination of high levels of GDF15, MMP7 and miR-200c was an independent predictor for death (p = 0.033). Conclusion: GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients. © 2014 Future Medicine Ltd. Source