9 rue Maurice Alet

Toulouse, France

9 rue Maurice Alet

Toulouse, France

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Blanc S.,University Hospital Lenval | Bourrier T.,University Hospital Lenval | Boralevi F.,Bordeaux University Hospital Center | Sabouraud-Leclerc D.,Hopital Americain | And 10 more authors.
Journal of Pediatrics | Year: 2016

Objective To describe the features of Frey syndrome (auriculotemporal nerve dysfunction with gustatory flushing) in childhood. Study design A multicenter, retrospective, descriptive observational national case series study was conducted with the help of French academic societies. Diagnostic criteria were based on clinical history, and sometimes also on photographs or provocation tests. Results Forty-eight cases were identified, with 2 subtypes: 35 unilateral and 13 bilateral. Associated sweating was reported in only 10% of cases. Diagnosis was made in only 20% of children at the first consultation and inappropriate dietary restriction was prescribed for 21%. Instrumented vaginal delivery was significantly associated with unilateral forms (OR [unilateral vs bilateral] = 29; 95% CI 3.99-311.58; P <.001). The outcome was favorable overall with 57% regression, 20% recovery, and only 23% persistence of initial symptoms. Regression was more frequent in unilateral forms (OR = 6.60; 95% CI 1.23-44.04; P =.016), observed in 69% of unilateral forms at a median age of 27 (24-48) months. Recovery predominated in bilateral forms (OR = 0.05; 95% CI 0-0.38; P =.001), observed in 58% of bilateral cases at a median age of 8 (7-9) months. Conclusions Frey syndrome in childhood is a rare but benign condition with mild symptoms and a favorable outcome in most cases. Unilateral forms are mostly associated with instrumented delivery. Pediatricians should be familiar with this disorder in order to avoid misdiagnosis, mainly as food allergy, and unnecessary referrals and tests. © 2016 Elsevier Inc.


Blanc S.,Hopitaux Pediatriques Of Nice University Hospital Lenval | Bourrier T.,Hopitaux Pediatriques Of Nice University Hospital Lenval | Boralevi F.,Bordeaux University Hospital Center | Sabouraud-Leclerc D.,Hopital Americain | And 10 more authors.
Journal of Pediatrics | Year: 2016

Objective: To describe the features of Frey syndrome (auriculotemporal nerve dysfunction with gustatory flushing) in childhood. Study design: A multicenter, retrospective, descriptive observational national case series study was conducted with the help of French academic societies. Diagnostic criteria were based on clinical history, and sometimes also on photographs or provocation tests. Results: Forty-eight cases were identified, with 2 subtypes: 35 unilateral and 13 bilateral. Associated sweating was reported in only 10% of cases. Diagnosis was made in only 20% of children at the first consultation and inappropriate dietary restriction was prescribed for 21%. Instrumented vaginal delivery was significantly associated with unilateral forms (OR [unilateral vs bilateral] = 29; 95% CI 3.99-311.58; P < .001). The outcome was favorable overall with 57% regression, 20% recovery, and only 23% persistence of initial symptoms. Regression was more frequent in unilateral forms (OR = 6.60; 95% CI 1.23-44.04; P = .016), observed in 69% of unilateral forms at a median age of 27 (24-48) months. Recovery predominated in bilateral forms (OR = 0.05; 95% CI 0-0.38; P = .001), observed in 58% of bilateral cases at a median age of 8 (7-9) months. Conclusions: Frey syndrome in childhood is a rare but benign condition with mild symptoms and a favorable outcome in most cases. Unilateral forms are mostly associated with instrumented delivery. Pediatricians should be familiar with this disorder in order to avoid misdiagnosis, mainly as food allergy, and unnecessary referrals and tests. © 2016 Elsevier Inc.


PubMed | Hopitaux Pediatriques Of Nice University Hospital Lenval, University of Nice Sophia Antipolis, 9 rue Maurice Alet, Lille University Hospital Center and 5 more.
Type: | Journal: The Journal of pediatrics | Year: 2016

To describe the features of Frey syndrome (auriculotemporal nerve dysfunction with gustatory flushing) in childhood.A multicenter, retrospective, descriptive observational national case series study was conducted with the help of French academic societies. Diagnostic criteria were based on clinical history, and sometimes also on photographs or provocation tests.Forty-eight cases were identified, with 2 subtypes: 35 unilateral and 13 bilateral. Associated sweating was reported in only 10% of cases. Diagnosis was made in only 20% of children at the first consultation and inappropriate dietary restriction was prescribed for 21%. Instrumented vaginal delivery was significantly associated with unilateral forms (OR [unilateral vs bilateral]=29; 95% CI 3.99-311.58; P<.001). The outcome was favorable overall with 57% regression, 20% recovery, and only 23% persistence of initial symptoms. Regression was more frequent in unilateral forms (OR=6.60; 95% CI 1.23-44.04; P=.016), observed in 69% of unilateral forms at a median age of 27 (24-48) months. Recovery predominated in bilateral forms (OR=0.05; 95% CI 0-0.38; P=.001), observed in 58% of bilateral cases at a median age of 8 (7-9) months.Frey syndrome in childhood is a rare but benign condition with mild symptoms and a favorable outcome in most cases. Unilateral forms are mostly associated with instrumented delivery. Pediatricians should be familiar with this disorder in order to avoid misdiagnosis, mainly as food allergy, and unnecessary referrals and tests.


Petrus M.,Service Dhospitalisation Of Jour Of Pediatrie | Assih L.,Service Dhospitalisation Of Jour Of Pediatrie | Horen B.,Service Dhospitalisation Of Jour Of Pediatrie | Lapebie P.,Service Dhospitalisation Of Jour Of Pediatrie | And 5 more authors.
Revue Francaise d'Allergologie | Year: 2010

The authors present the case of a 13-year-old boy who presented with an acute episode of urticaria and asthma after having swallowed five spiruline tablets. Allergy was confirmed by skin prick test, labial challenge and oral provocation test. The responsible allergen is a high molecular weight protein (~430,000 Da), C-phycocyanin. © 2010 Elsevier Masson SAS.


El Zoobi M.,Service de pediatrie | Bidat E.,Service de pediatrie | Leduc V.,Laboratoire ALK France | Dutau G.,9 rue Maurice Alet
Revue Francaise d'Allergologie | Year: 2013

A case of non-fatal anaphylaxis in an asthmatic child led us to suspect food allergy to an emerging allergen: fenugreek. The case we report here is special because of the severity of the patient's asthmatic attacks, the existence of previous recurrent episodes of food allergy which had been ignored due to the severity of the child's asthma, and because of the importance of the co-factors which were the cause of the food allergy. © 2013 Elsevier Masson SAS.


Dutau G.,9 rue Maurice Alet | Lavaud F.,Reims University Hospital Center
Revue Francaise d'Allergologie | Year: 2012

The relationship between serum vitamin D levels and atopy is an up to date topic. Most studies, particularly transversal and observational studies, demonstrate that there is a relationship between vitamin D deficiency and symptoms of atopy (rhinitis, asthma, atopic dermatitis, food allergies). Vitamin D deficiency is more frequently observed in atopic children than in controls in the general population. Vitamin D could play a major role in the genesis of allergies because of its multiple extra- osseous effects, particularly on natural and acquired immunity. Variations in exposure to UV- B radiation leading to differences in vitamin D synthesis could explain the North- South gradient described in epidemiological studies for most symptoms of atopy. The same theory could explain the significant excess in food allergies observed in children born during the cold season in both hemispheres. In some studies, prescription of vitamin D to patients with deficiencies improved their symptoms, i.e. better control of asthma, improvement in atopic dermatitis scores. The demonstration that the vitamin D status of pregnant women has an effect on the later development of allergic or infectious diseases (bronchiolitis, tuberculosis) in their children further accentuated the importance of the relationship between vitamin D, atopy and immunity. Large, prospective studies are currently underway to define the precise nature of this relationship and its practical clinical impact. © 2012 Elsevier Masson SAS.


Bidat T.,Service de pediatrie | Dutau G.,9 rue Maurice Alet
Revue Francaise d'Allergologie | Year: 2013

A pediatric case gives us a chance to discuss the principal aspects of allergy to buckwheat, an emerging food allergen, with a reactive threshold often very low. The symptoms of this allergy, often severe, appear after ingestion but also after its inhalation. Other specific lessons taken from this pediatric case include the perfect management of the anaphylaxis by the pediatric emergency service (Samu), including the correct use of injectable adrenalin, the importance of close communication between the patient's parents and the specialist via the Internet, plus the interest of food and restaurant professionals on the notion of masked allergens. © 2013 Elsevier Masson SAS.


Rance F.,Allergologie Pneumologie | Dutau G.,9 rue Maurice Alet
Revue Francaise d'Allergologie | Year: 2010

Egg allergy is one of the 3 main food allergy involved in children. The most common symptoms are IgE-mediated, furthermore, gastrointestinal symptoms were described. The diagnostic work-up is improved using recent technology with single allergens such as ovomucoid and ovalbumin. The management distinguished children who react both to raw as well as heated egg with other children tolerating cooked egg. The prognosis of egg allergy is better in children who tolerated heated egg. Promising management are expected with induction of tolerance protocols. © 2010 Elsevier Masson SAS.


Dutau G.,9 rue Maurice Alet | Rance F.,Allergologie Pneumologie
Revue Francaise d'Allergologie | Year: 2010

The wealth of allergology news continues to thrive year by year. The most important subjects remain allergens and food allergies, asthma which is difficult to treat, pollen allergies and anaphylaxis. The latter are still underestimated by doctors whatever their domain of involvement, both general practitioners and emergency physicians. © 2010 Elsevier Masson SAS.


The American Academy of Allergy, Asthma & Immunology (AAAAI) conference took place in New Orleans from 26 February to 2 March 2010. Apart from the plenary sessions, the conference presented 931 posters comprising the best of what the world's major teams in allergology have produced in the past year, which will become original articles, case reports, or review articles. The selection presented in this issue is organized around the discipline's main topics: asthma, allergens and food allergies, aeroallergens and allergic rhinitis, allergy treatments, and specific immunotherapy. © 2010 Elsevier Masson SAS. All rights reserved.

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