the 81st Hospital of Peoples Liberation Army
the 81st Hospital of Peoples Liberation Army
Sun G.,Nantong University |
Lu J.,The Affiliated Huaian Hospital of Xuzhou Medical University |
Zhang C.,The 81st Hospital of Peoples Liberation Army |
You R.,Nantong University |
And 6 more authors.
Oncotarget | Year: 2017
MiR-29b is widely involved in diverse cancers. We plan to study its role in glioma. The expression of miR-29b was detected by real-time polymerase chain reaction (PCR) and we found the expression of miR-29b was decreased in glioma. Cell proliferation was evaluated by cell counting kit (CCK8) and 5-Ethynyl-2'- deoxyuridine (EdU) and cell apoptosis was assayed with flow cytometry assay (FCA), which indicated miR-29b can inhibit the proliferation and promote the apoptosis of glioma cells. The target of miR-29b was predicted using miRanda, TargetScan and PicTar sofeware and we also found MYCN was a direct target of miR-29b in glioma cells and miR-29b inhibited the proliferation of glioma cells via MYCN dependent way. Subcutaneous xenotransplantation model was designed to investigate the affection of miR-29b on glioma growth. The effectiveness of miR-29b for glioma prediction was also performed and we determined miR-29b can stably exist and may act as a biomarker for the diagnosis of glioma. As a conclusion, miR-29b inhibits the growth of glioma via MYCN dependent way and can be a biomarker for the diagnosis of glioma. © Sun et al.
Liu G.,the 81st Hospital of Peoples Liberation Army
Zhonghua wai ke za zhi [Chinese journal of surgery] | Year: 2016
OBJECTIVE: To investigate the effects of initiative and passive perioperative function exercises on hidden blood loss (HBL).METHODS: Two hundreds and thirty elderly patients with hip fractures aging from 67 to 87 years (average age of 73.6 years) who underwent total hip replacement were included. By the intensity and the manner of perioperative function exercises, patients were divided into four groups: little initiative function exercises group (group A, n=51), little initiative and passive function exercises group (group B, n=54), normal initiative function exercises group (group C, n=65), normal initiative and passive function exercises group (group D, n=60). The true total blood loss, HBL and their proportion on the original blood volume and total blood loss was calculated depending on height, weight, intra-operative blood loss, post-operative blood loss, pre- and post-operative hematocrit, and blood transfused. According to the proportion of mean HBL on total blood loss, patients were divided into low HBL group and high HBL group. The data were analyzed by t test.RESULTS: The mean HBL was 517 ml, 41.9% of the total blood loss. Thereinto, the mean HBL was 695 ml in group A, 49.3% of the total blood loss, the prevalence of high HBL was 66.7% (34/51); the mean HBL was 625 ml in group B, 46.9% of the total blood loss, the prevalence of high HBL was 59.3% (32/54); the mean HBL was 446 ml in group C, 38.4% of the total blood loss, the prevalence of high HBL was 30.8% (20/65); the mean HBL was 346 ml in group D, 32.3% of the total blood loss, the prevalence of high HBL was 20.0% (12/60). Mean HBL, mean HBL/total blood loss, prevalence of high HBL were lower in group C than that in group A and group B (all P<0.05); and were lower in group D than that in group C (all P<0.05). The prevalence was 57.4% (132 cases) in low HBL group, and 42.6% (98 cases) in high HBL. The proportion of little initiative function exercises patients in high HBL group was obviously higher than that in low HBL group (P<0.05).CONCLUSIONS: The intensity and the manner of perioperative function exercises are strongly associated with the HBL in elderly patients with total hip replacement. The initiative combined with the passive function exercises could be effectively prevent and reduce the incidence of high HBL.
Xu H.-B.,The 81St Hospital Of Peoples Liberation Army |
An Z.-T.,The 81St Hospital Of Peoples Liberation Army |
Xuan J.,The 81St Hospital Of Peoples Liberation Army |
Wen W.,The 81St Hospital Of Peoples Liberation Army
World Chinese Journal of Digestology | Year: 2017
Evidence-based medicine is the use of the best evidence to evaluate the safety and effectiveness of clinical treatments. Esophagogastric variceal bleeding (EVB) is a common critical gastrointestinal disease, seriously threatening the life and the physical and mental health of patients with cirrhosis. In recent years, there is an urgent need among clinicians to effectively use evidence-based medicine to find the best clinical evidence and formulate evidence-based treatment regimens for EVB. This paper reviews the progress in evidencebased endoscopic treatment of esophagogastric variceal bleeding. © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.