Xiong R.-H.,81 Hosptal of Peoples Liberation Army |
Tian X.-R.,81 Hosptal of Peoples Liberation Army |
Wu J.-W.,81 Hosptal of Peoples Liberation Army |
Ren Q.,81 Hosptal of Peoples Liberation Army |
And 3 more authors.
Objective: To evaluate the efficacy of thoracic perfusion with cytokine induced killer (CIK) cells in the treatment of malignant pleural effusion. Methods: The thirty-three patients were given PICC implementation and thoracic infusion therapy. All the patients were randomly divided into 2 groups. For patients in control group 40 mg of cisplatin and 0.75 g of 5-FU were administered to the pleural cavities twice a week for 1 to 2 weeks. For patients in study group the CIK cells were transfused at 1 × 109 per dosage, once per day for 3 consecutive days. Results: Study group obtained better therapeutic efficacy in controlling the malignant pleural effusion. The living quality and the number of white blood cells in peripheral blood in study group was higher than those of control group. Conclusion: Thoracic perfusion with CIK cells was effective in the treatment of malignant pleural effusion in the patients with advanced tumor. It had better efficacy, mild adverse reaction, and good safety. It could effectively increase the living quality of the patients to obtain the opportunity for further treatment. Source