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New Philadelphia, PA, United States

DeSantis M.E.,805B Stellar Chance Laboratories | DeSantis M.E.,University of Pennsylvania | DeSantis M.E.,Harvard University | Sweeny E.A.,805B Stellar Chance Laboratories | And 11 more authors.
Journal of Biological Chemistry | Year: 2014

Background: How Hsp104 and ClpB coordinate polypeptide handover with Hsp70 to dissolve disordered protein aggregates is unknown. Results: Conserved distal loop residues in the Hsp104 and ClpB middle domain contact NBD2 and enable Hsp70-dependent protein disaggregation. Conclusion: Distal loop does not project out into solution and Hsp104 and ClpB are tuned differently for Hsp70 collaboration. © 2014 by the American Society for Biochemistry and Molecular Biology, Inc. . Source

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