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Bloomington, IN, United States

Rogers D.A.,800 E Kirkwood Ave | Ray S.J.,800 E Kirkwood Ave | Hieftje G.M.,800 E Kirkwood Ave
Metallomics | Year: 2010

A new time-of-flight mass spectrometer has been developed that uses an electrospray source and an inductively coupled plasma to extract molecular, atomic, and isotopic information simultaneously from a single sample. This paper will focus on characterization of the ESI channel. Sensitivities are reported for hexadecyltrimethylammonium, tetrahexylammonium, tetraoctylammonium, myoglobin, insulin, cyanocobalamin, leucine enkephalin, and alcohol dehydrogenase. Skimmer-nozzle collisionally induced dissociation is explored for adduct removal and analyte fragmentation on the ESI channel for tetraoctylammonium ion and leucine enkephalin. Long-term and short-term spray stability is also examined. © 2010 The Royal Society of Chemistry. Source


A new Time-of-Flight Mass Spectrometer (TOFMS) has been developed that employs an electrospray source and an inductively coupled plasma simultaneously to provide molecular, structural, atomic, and isotopic information from a sample. This paper will focus on characterization of the ICP source and will demonstrate simultaneous operation of the two sources. Preliminary sensitivities and limits of detection for Cr, Co, Ga, As, Ag, Cs, Ho, Hg, Tl, and Bi on the ICP channel are reported. Long-term stability and drift of the ICP channel are also discussed. Simultaneous operation of both channels is demonstrated for cyanocobalamin, myoglobin, and superoxide dismutase. © 2010 The Royal Society of Chemistry. Source

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