7th April University

Az Zāwīyah, Libya

7th April University

Az Zāwīyah, Libya
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Sreekanth N.,Jimma University | Awen B.Z.,7th April University | Rao C.B.,7th April University
Journal of Advanced Pharmaceutical Technology and Research | Year: 2010

A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and completely validated for the estimation of trandolapril in bulk and pharmaceutical dosage forms. Quantification of trandolapril was carried out with percolated silica gel 60F254 as stationary phase using mobile phase consisting of Chloroform: Methanol: Acetic acid (8:1.5:0.5 v/ v/ v) and scanned in Absorbancei Reflectance mode at 212 nm using Camag TLC scanner 3 with WinCAT software. The Rf value of trandolapril was found to be 0.54 (±0.03). The proposed method has permitted the quantification of trandolapril over the linearity range of 25-150 ng/spot and its percentage recovery was found to 99.7%. The intraday and inter day precision were found to be 1.26% and 1.4%, respectively. The limit of detection and the limit of quantification were found to be 18 ng/ spot and 54 ng/ spot, respectively. The proposed method can be successfully applied for the estimation of drug content of different marketed formulations simultaneously on a single plate and provides a faster and cost effective quality control tool for routine analysis of trandolapril as bulk drug and in tablet dosage forms. © JAPTR, All Rights Reserved.

Pendyala V.,Siddharth Institute of Pharmacy | Baburao C.,7th April University | Chandrasekhar K.B.,JNTUA
Journal of Advanced Pharmaceutical Technology and Research | Year: 2010

Gum exudates from Leucaena Leucocephala (Family: Fabaceae) plants grown all over India were investigated for its physicochemical properties such as pH, swelling capacity and viscosities at different temperatures using standard methods. Leucaena Leucocephala bark gum appeared to be colorless to reddish brown translucent tears. 5 % w/v mucilage has pH of 7.5 at 28C. The gum is slightly soluble in water and practically insoluble in ethanol, acetone and chloroform. It swells to about 5 times its original weight in water. A 5 %w/ v mucilage concentration gave a viscosity value which was unaffected at temperature ranges (28-40°C). At concentrations of 2 and 5 %w/v, the gum exhibited pseudo plastic flow pattern while at 10 %w/v concentration the flow behaviour was thixotropic. The results indicate that the swelling ability of Leucaena Leucocephala (LL) bark gum may provide potentials for its use as a disintegrant in tablet formulation, as a hydro gel in modified release dosage forms and the rheological flow properties may also provide potentials for its use as suspending and emulsifying agents owing to its pseudo plastic and thixotropic flow patterns. © JAPTR, All Rights Reserved.

Awen B.Z.,7th April University | Ganapaty S.,Andhra University | Chandu B.R.,7th April University | Katakam P.,7th April University | Peraman R.,Raghavendra Institute of Pharmaceutical Education and Research
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

The influence of Sapindus mukorossi Gaertn, a member of Sapindaceae family (Popularly known as Soap nut) on the permeability of ethylcellulose free films was studied with a view to develop suitable rate controlling membranes for transdermal use. Dibutyl phthalate was incorporated at a concentration of 40% w/w of dry polymer as plasticizer. The dry free films were evaluated for various mechanical properties whereas the permeability characteristics of free films were studied using propranalol hydrochloride and diltiazem hydrochloride as model drugs. Both water vapour transmission and drug diffusion rate followed zero order kinetics. The spray dried powder of Sapindus mukorossi pericarps extract showed a significant influence on the mechanical as well as permeability characteristics. This may be due to difference in the affinity of Sapindus mukorossi with the film former. From this study it was concluded that the plasticized free films of ethylcellulose prepared with eco-friendly Sapindus mukorossi can be used as rate controlling membranes to develop transdermal drug delivery systems.

Ezzat M.H.M.,Ain Shams University | Imam S.S.,Ain Shams University | Shaheen K.Y.A.,Ain Shams University | Elbrhami E.M.,7Th April University
Allergy and Asthma Proceedings | Year: 2011

The costimulatory molecule OX40 and its ligand, OX40L, mediate key aspects of allergic airway inflammation in animal models of asthma, including eosinophilic airway inflammation, airway hyperresponsiveness, and T-helper type 2 (Th2) polarization. However, involvement of these molecules in Th2-dominated allergen-induced childhood asthma remains unclear. Therefore, we sought to examine OX40L expression in pediatric asthma across disease activity and attack severity. Serum OX40L concentrations were measured by ELISA in 50 children with atopic asthma (during and in between acute attacks), and in 40 healthy children serving as controls. The median and mean (SD) serum OX40L levels (1487 and 1560 [543] pg/mL) were significantly higher in asthmatic children during acute attacks in comparison with children in between attacks (731 and 689 [321] pg/mL) and in comparison with controls (193 and 157 [60.3] pg/mL). OX40L values were higher among children who presented with acute severe asthma exacerbations than in children with mild or moderate asthma exacerbations. During stability, patients with severe persistent asthma had significantly higher levels when compared with patients with moderate or mild persistent asthma. A positive correlation could be elicited between OX40L levels during exacerbations and the corresponding values during remission. Serum OX40L levels correlated negatively with peak expiratory flow rate and positively with absolute eosinophil count. Up-regulation of OX40L may play a critical role in development of childhood atopic asthma and is in favor of asthma severity. OX40L may represent a useful biomarker of monitoring allergic inflammation. OX40L is one of the most promising targets of immune intervention for treatment of these diseases. Copyright © 2011, OceanSide Publications, Inc., U.S.A.

Khalifa M.kh.,University of New South Wales | Khalifa M.kh.,7th April University | Ward C.R.,7th April University
Australian Journal of Earth Sciences | Year: 2010

Detailed sedimentological analysis, using lithological samples (cores and cuttings) and wireline-log information, has been carried out on the Devonian subsurface strata of the Darling Basin, to aid in the development of a geological model for the Mulga Downs Group in the Blantyre, southern Pondie Range and western Neckarboo Sub-basins. The Mulga Downs Group displays five different lithofacies successions, which are visible in both vertical and horizontal sections. The lower part of the Mulga Downs Group (Snake Cave Interval) is a succession composed mainly of braided fluvial and meandering fluvial lithofacies, with minor fluvial-shallow lacustrine complex lithofacies. The upper part of the Mulga Downs Group (Ravendale Interval) contains braided fluvial and meandering fluvial lithofacies passing upwards into estuarine tidal channel deposits and a nearshore lithofacies complex contemporaneous with a nearshore braided-deltaplain complex lithofacies. The results of this study, which included core and cutting descriptions and geophysical log (mainly gamma-ray logs) correlations, and comparisons with other large sandstone- and siltstone-rich sediment-supply fluvial systems in the subsurface data in the central part of the Darling Basin, suggest that the Mulga Downs Group has excellent reservoir potential and stratigraphic-trap configuration. © 2010 Geological Society of Australia.

Adak M.,National Medical College and Teaching Hospital | Gabar M.A.,7th April University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

Tea is the most popular drink after water, consumed everyday by millions of people around the world. Tea is generally consumed in the forms of green, oolong, and black tea, all of which originate from the leaves of the plant Camellia sinensis. Tea consumption began about 5000 years ago in southwest China, where it was used medicinally to treat various illnesses. Health benefits are believed to be largely due to the presence of high levels of flavonoids. Recent human studies suggest that green tea may contribute to a reduction in the risk of cardiovascular disease and some forms of cancer, as well as to the promotion of oral health. In addition, green tea possesses significant antioxidant, anti-inflammatory, antimicrobial, antihypertensive, thermogenic properties. Increasing interest in its health benefits has led to the inclusion of green tea in the group of beverages with functional properties. The present review focuses on the beneficial effects of tea consumption on human health. © 2010 RJPBCS.

Abd El-Ghani M.,Cairo University | Soliman A.,Cairo University | Hamdy R.,Cairo University | Bennoba E.,7th April University
Turkish Journal of Botany | Year: 2013

Deserts comprise about 95% of the total land surface of Egypt; therefore, their potential for production must be assessed. Weed communities are mainly affected by the environment, and studies may increase our knowledge of the relationship among the weed flora, soil properties, crop rotation, soil management, fertiliser usage, and weed control. The area under study is one of the most recently reclaimed lands. The recorded 150 species in the monitored 19 sites were distributed within 33 families. The species-rich families were: Poaceae (31), Asteraceae (23), Brassicaceae (13), Chenopodiaceae (12), and Fabaceae (12). Chorological analysis revealed that the widely distributed species belonging to cosmopolitan, palaeotropical, and pantropical chorotypes constituted about 39.3% of the recorded flora. Pure Mediterranean species were very poorly represented, while biregional and triregional Mediterranean chorotypes constituted 28%. Saharo-Arabian chorotypes, either pure or penetrated into other regions, constituted 32%. Ubiquitous species with wide amplitude were Cynodon dactylon (L.) Pers. and Sonchus oleraceus L. Species richness varied from one crop to another. The winter weeds represented the main bulk of the recorded species within each crop, desert perennials exhibited notable variations, and margin species were the lowest. Redundancy analysis demonstrated the effect of soil organic matter, coarse sand, fine sand, silt, and soil saturation point on the spatial distribution of weed communities. The species-environment correlations were higher for the 4 axes, explaining 64.1% of the cumulative variance. The variations in soil pH, bicarbonates, ammonia, silt, and sulphate contents classified the vegetation into 4 site (vegetation) groups. Application of cluster analysis of species in crop-orchard farmlands resulted in 4 floristic groups (A-D). The weed species of the 2 winter crops, Egyptian clover and wheat, separated in Group A, tomato (winter/summer crop) in Group B, maize as a summer crop in Group C, and weeds of olive orchards and vineyards in Group D. This demonstrated high significant correlations between the olive and vineyard orchards (P < 0.01), and between the 2 winter crops, wheat and clover. © TÜBİTAK.

Sreekanth N.,Jimma University | Awen B.Z.,7th April University | Babu Rao C.,7th April University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

A new colorimetric method was developed for the estimation of Sparfloxacin in bulk and pharmaceutical dosage forms, based on the formation of a yellowish colored ferric ion complex with ferric nitrate solution. The yellow color may be due to the complex formation between the drug and added ferric ions. The absorption maximum for the above method was found to be 430nm. The formed chromogen obeyed beer's law in the concentration range of 20 - 100 μg/ml. The developed method was validated as per the ICH guidelines.

Sreekanth N.,Jimma University | Awen B.Z.,7th April University | Babu Rao C.H.,7th April University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

A simple and accurate RP-HPLC method has been developed for the estimation of Capecitabine in bulk and pharmaceutical dosage forms, using C8 Hypersil BDS (Base Deactivated Silane) 250 × 4.6 × 5μ particle size in isocratic mode, with mobile phase comprising of buffer (pH 2.3-2.5) and Acetonitrile in the ratio of 80:40 v/v. The flow rate was 1.2 ml/min and the detection was monitored out by UV detector at 240nm. The retention time for Capecitabine was found to be 5.825min.The proposed method has permitted the quantification of Capecitabine over linearity in the range of 20-120 μg/ml and its percentage recovery was found to be 99.96-100.32 %. The intra day and inter day precision were found 0.16% and 0.10%, respectively.

Handoo Irshad A.,7th April University
Advances in Environmental Biology | Year: 2011

Tomato is one of the most important vegetable crops from nutritional as well as consumptional point of view. It tops the list of canned vegetables. In this study tomato plants were treated with organic manures (F.Y.M, Sewage sludge) and inorganic fertilizers (N.P.K, Zn, S) were analysed for biochemical composition. T.S.S, lycopene, carbohydrate, vit. C, acidity, oxalic acid and carotenoid content exhibited an increase at all the test concentrations and were found maximum in sewage sludge treated along with N.P.K (T 7).

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