Cottrell E.,Trentham Mews Medical Center |
Cox T.,79 Group |
O'Connell P.,79 Group |
Chambers R.,79 Group
BMC Family Practice | Year: 2015
Background: Hypertension is common and conveys significant risk of morbidity and mortality. However, inadequate control of hypertension is common. Following a successful local use of a simple telehealth intervention ('Florence') for the diagnosis and management of hypertension, the Advice & Interactive Messaging (AIM) for Health simple telehealth programme was launched across England in March 2013. Four protocols were developed to diagnose and monitor blood pressure (BP). The aim of this service evaluation was to identify the extent to which predefined service outcomes, regarding ascertainment of a diagnosis of hypertension, and achievement of hypertension control, were met for the hypertension protocols. Methods: Patients with opportunistic raised BP in general practice or diagnosed hypertension were selected by their usual primary care providers to register onto diagnostic or monitoring hypertension protocols, respectively. Florence sent patients prompts via text messaging to submit readings, educational messages and user satisfaction questions. Patient responses were stored on Florence for review by their primary care health providers. This service evaluation used data from 2963 patients from general practices across England registered onto one of four AIM hypertension protocols from inception to January 2014. Data were extracted from Florence and underwent descriptive analysis. Results: 1166/1468 (79 %) patients were eligible to have a diagnosis of hypertension confirmed/refuted, of which 740 (63 %) had a mean BP in the hypertensive range from one week's readings. BP control was achieved by only 5-22 % of 1495 patients signed up to one of the three monitoring protocols. Patient engagement with the monitoring protocols was initially good but reduced over time. Conclusions: Although simple telehealth may be an acceptable tool for diagnosing and monitoring hypertension among responding patient users, and can have a useful role in diagnosis of hypertension (particularly if ambulatory blood pressure monitoring (ABPM) is not possible or is declined), problems were identified. Reduced patient engagement over longer periods and acceptance of suboptimal BP control among patients on monitoring protocols need to be urgently addressed. Empirical work is required to identify barriers to achieving BP control among hypertensive patients using simple telehealth and, consequently, services be developed to address these issues. © 2015 Cottrell et al.
Elsamani M.,79 Group |
Neville A.,University of Leeds |
Ukpai J.,Elite Coil Tubing Solutions LLC Greenwood
NACE - International Corrosion Conference Series | Year: 2016
Erosion and erosion-corrosion are significant threats in the oil and gas industry. Erosion-corrosion is attributed to the combination of electrochemical dissolution due to the presence of corrosive agents and mechanical damage caused by particle impingement. For this study, Acoustic Emission (AE) signals are recorded at various impact angles under erosion and erosion-corrosion conditions using the Submerged Impinging Jet (SIJ) system. Laboratory experiments were carried-out at 15°, 30°, 45° and 90° nominal impact angles. Parameters such as flow velocity, solution temperature and sand loading were controlled in both conditions. A correlation between AE signal and metal loss is produced and the influence of corrosion on AE signal attenuation is also highlighted. © 2016 by NACE International.
Skruzny M.,Cell Biology and Biophysics Unit |
Skruzny M.,Max Planck Institute for Terrestrial Microbiology |
Desfosses A.,Cell Biology and Biophysics Unit |
Desfosses A.,Structural and Computational Biology Unit |
And 17 more authors.
Developmental Cell | Year: 2015
Clathrin-mediated endocytosis, the main trafficking route from the plasma membrane to the cytoplasm, is critical to many fundamental cellular processes. Clathrin, coupled to the membrane by adaptor proteins, is thought to play a major structural role in endocytosis by self-assembling into a cage-like lattice around the forming vesicle. Although clathrin adaptors are essential for endocytosis, little is known about their structural role in this process. Here we show that the membrane-binding domains of two conserved clathrin adaptors, Sla2 and Ent1, co-assemble in a PI(4,5)P2-dependent manner to form organized lattices on membranes. We determined the structure of the co-assembled lattice by electron cryo-microscopy and designed mutations that specifically impair the lattice formation invitro. We show that these mutations block endocytosis invivo. We suggest that clathrin adaptors not only link the polymerized clathrin to the membrane but also form an oligomeric structure, which is essential for membrane remodeling during endocytosis. © 2015 Elsevier Inc.
PubMed | EMBL Hamburg Unit, Cell Biology and Biophysics Unit, Structural and Computational Biology Unit and 79 Group
Type: Journal Article | Journal: Developmental cell | Year: 2015
Clathrin-mediated endocytosis, the main trafficking route from the plasma membrane to the cytoplasm, is critical to many fundamental cellular processes. Clathrin, coupled to the membrane by adaptor proteins, is thought to play a major structural role in endocytosis by self-assembling into a cage-like lattice around the forming vesicle. Although clathrin adaptors are essential for endocytosis, little is known about their structural role in this process. Here we show that the membrane-binding domains of two conserved clathrin adaptors, Sla2 and Ent1, co-assemble in a PI(4,5)P2-dependent manner to form organized lattices on membranes. We determined the structure of the co-assembled lattice by electron cryo-microscopy and designed mutations that specifically impair the lattice formation in vitro. We show that these mutations block endocytosis in vivo. We suggest that clathrin adaptors not only link the polymerized clathrin to the membrane but also form an oligomeric structure, which is essential for membrane remodeling during endocytosis.
Lena R.,Geologic Lunar Research GLR Group |
Fitzgerald B.,79 Group
Planetary and Space Science | Year: 2014
In this study we examine a lunar pyroclastic deposit (LPD) identified using LROC WAC images, Selene-1 (Kaguya) and Clementine multispectral data, the Chandryann-1's Moon Mineralogy Mapper (M3), and the LROC WAC-based GLD100 DTM. Selene-1 (Kaguya) and Clementine albedo imagery indicates the presence of pyroclastic deposits located some 40 km to the west-southwest of the crater Yangel in Mare Vaporum, and to the southeast of Sinus Fidei (16.42 N and 3.26 E), and associated with a dome like structure. This dome, which we term Yangel 1 (Ya1), lies immediately to the south of a mare flooded crater which is approximately 7.5 km in diameter, and is partially buried along its southern rim by the domes northern flank. With a diameter of 5.2 km, and a height of 620 m, the dome Ya1 exhibits evidence of pyroclastic volcanic deposits, both on its surface and peripherally. The current study discusses the dome Ya1, the associated deposits and possible relationship between them. © 2014 Elsevier Ltd.
PubMed | Son Espases Hospital, 79 Group and University of the Balearic Islands
Type: | Journal: AIDS research and treatment | Year: 2015
The main aim of this study is to describe the relationship between serum levels of atazanavir, renal toxicity, and lithiasis. This is a prospective observational study of patients being treated with atazanavir (ATV) at Son Espases Teaching Hospital, Palma de Mallorca, between 2011 and 2013. The study includes 98 patients. Sixteen were found to have a history of urolithiasis. During a median monitoring period of 23 months, nine patients suffered renal colic, in three of whom ATV crystals were evidenced in urine. Cumulative incidence of renal colic was 9.2 per 100 patients. The variables related to having renal colic were the presence of alkaline urine pH and lower basal creatinine clearance. The mean serum level of ATV was slightly higher in patients with renal colic-1,303g/L versus 1,161g/L-but did not reach statistical significance. Neither were any significant differences detected by analysing the levels according to the timetable for ATV dosage. Cumulative incidence of renal colic was high in patients being treated with ATV, in 33% of whom the presence of ATV crystals was evidenced in urine. We were unable to demonstrate a relationship between ATV serum levels and renal colic or progression towards renal failure.
Dick R.,79 Group
Lighting Research and Technology | Year: 2014
Studies of our illuminated environment demonstrate the importance of light to humans, who by evolution are essentially daytime creatures. However, the study of behaviour and the biology that occurs during the night has clearly shown the importance of darkness for both humans and the ecological integrity of the countryside. Since humans are expanding their activity throughout the night and into rural areas, is there a compromise between the human desire for light and the need for darkness? All animals and plants have light thresholds to which they have evolved. We have applied the findings of scotobiology to determine outdoor lighting that minimizes the disruption of artificial light at night on the natural environment and on human health. It is not surprising that the key characteristics to be limited are the brightness, duration and extent of the emitted light, the amount of glare and the spectrum of the emitted light. To test the practicality of these limits, we present the patented design of a luminaire that bridges the desire for 24 × 7 human lifestyles and the protection of the nocturnal environment. © 2013 The Chartered Institution of Building Services Engineers.
Arulsamy A.D.,79 Group
Progress of Theoretical Physics | Year: 2011
A general quantum adiabatic theorem with and without the time-dependent orthogonalization is proven, which can be applied to understand the origin of activation energies in chemical reactions. Further proofs are also developed for the oscillating Schwinger Hamiltonian to establish the relationship between the internal (due to time-dependent eigenfunctions) and external (due to time-dependent Hamiltonian) timescales. We prove that this relationship needs to be taken as an independent condition for the quantum adiabatic approximation. We give four examples, including logical expositions based on the spin- 1/2 two-level system to address the gapped and gapless (due to energy level crossings) systems, as well as to understand how does this theorem allows one to study dynamical systems such as chemical reactions.
Karami A.,79 Group
Journal of the Iranian Chemical Society | Year: 2010
In this work the titanium dioxide powder was prepared by the optimized and simple Sol-Gel method and then characterized. The gelling pH was set to values of 3 (TiO2-A), 7 (TiO2-N) and 9 (TiO2-B) to observe the effect on the properties of the material. In these three cases nanoparticulated materials were obtained with particle sizes between 10nm and 20nm. The larger surface areas were obtained at pH 3, which is several times larger than the others. Furthermore, with the gelling condition pH 3, it was possible to synthesize pure anatase phase titania. Some preliminary results on the test of the photocatalytic activity of the synthesized materials in the reduction of nitric oxide are presented. Based on these results the nanoparticle TiO2, which was prepared in acidic pH 3 with the pure anatase phase and the lowest particle size has the highest reactivity for the photocatalytic reduction of nitric oxide.