4AZA Bioscience

Leuven, Belgium

4AZA Bioscience

Leuven, Belgium
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De Jonghe S.,4AZA Bioscience | Marchand A.,4AZA Bioscience | Gao L.-J.,4AZA Bioscience | Calleja A.,4AZA Bioscience | And 9 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2011

Screening of a pteridine-based compound library led to the identification of compounds exhibiting immunosuppressive as well as anti-inflammatory activity. Optimization afforded a series of 2-amino-4-N-piperazinyl-6-(3,4- dimethoxyphenyl)pteridine analogues. The most potent congeners in this series displayed low nM IC50 values in the Mixed Lymphocyte Reaction (MLR) assay. In addition, these compounds also have potent anti-inflammatory activity as measured in the Tumor Necrosis Factor (TNF) assay. © 2010 Elsevier Ltd. All rights reserved.

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