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Kyoto, Japan

Tsukano C.,46 29 Yoshida | Yokouchi S.,46 29 Yoshida | Girard A.-L.,46 29 Yoshida | Kuribayashi T.,46 29 Yoshida | And 3 more authors.
Organic and Biomolecular Chemistry | Year: 2012

The scope and limitations of the platinum catalyzed 7-endo cyclization of internal alkynyl amides were investigated. Substitution of the alkyne with an aryl group gave better results, presumably because it stabilized the transition state. Applying the reaction to a secondary amide, the caprazamycin core was successfully synthesized from commercially available material in eight steps. © 2012 The Royal Society of Chemistry. Source

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