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Xian, China

Liu X.,PLA Fourth Military Medical University | Shi M.,PLA Fourth Military Medical University | Xia F.,PLA Fourth Military Medical University | Han J.,PLA Fourth Military Medical University | And 9 more authors.
International Journal of Stroke | Year: 2015

Rationale: Epidemiological studies suggest that elevated homocysteine is linked to stroke and heart disease. However, the results of lowering homocysteine levels in reducing the risk of stroke recurrence are controversial. Aims: The study aims to evaluate whether homocysteine-lowering therapy with folic acid and vitamins B6 and B12 reduces recurrent stroke events and other combined incidence of recurrent vascular events and vascular death in ischemic stroke patients of low folate regions. Design: This is a multicenter, randomized, double-blinded, placebo-controlled trial. Patients (n=8000, α=0·05, β=0·10) within one-month of ischemic stroke (large-artery atherosclerosis or small-vessel occlusion) or hypertensive intracerebral haemorrhage with plasma homocysteine level ≥15μmol/l will be enrolled. Eligible patients will be randomized by a web-based, random allocation system to receive multivitamins (folic acid 0·8mg, vitamin B6 10mg, and vitamin B12 500μg) or matching placebo daily with a median follow-up of three-years. Study Outcomes: Patients will be evaluated at six monthly intervals. The primary outcome event is the composite event 'stroke, myocardial infarction, or death from any vascular cause', whichever occurs first. Secondary outcome measures include nonvascular death, transient ischemic attack, depression, dementia, unstable angina, revascularization procedures of the coronary, and cerebral and peripheral circulations. Discussion: This is the first multicenter randomized trial of secondary prevention for ischemic stroke in a Chinese population with a higher homocysteine level but without folate food fortification. © 2013 World Stroke Organization. Source

Du Z.,PLA Fourth Military Medical University | Liu H.,PLA Fourth Military Medical University | Zhang Z.,PLA Fourth Military Medical University | Li P.,451 Hospital of PLA
International Journal of Biological Macromolecules | Year: 2013

Radix Isatidis is an official herbal medicine for treatment of infection and inflammation in China. In this study, a novel heteropolysaccharide (RIWP) was isolated from R. Isatidis through DEAE Sepharose Fast Flow column and Sepharose CL-6B column. RIWP had a molecular weight of 57kDa and was mainly composed of glucose, galactose and arabinose with a relative molar ratio of 2.0:1.1:1.0. The cytoprotective, antioxidant and anti-inflammatory properties of RIWP in lipopolysaccharide (LPS) stimulated murine alveolar macrophages were first reported here. Pretreatment with RIWP was found to potently prolong cell survival and repress the generation of reactive oxygen species (ROS) and lipid peroxidation after LPS-stimulation in murine alveolar macrophages. Furthermore antioxidant status was significantly deteriorated in the LPS-treated alveolar macrophages, such as low superoxide dismutase (SOD) activity and G-SH content, which was effectively restored by RIWP supplementation. More importantly, RIWP significantly suppressed LPS-induced increase in nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) production in murine alveolar macrophages. Additionally RIWP recovered mitochondrial membrane potential to normal conditions. All above response to LPS stimulation behaved in a concentration-dependent manner. This study provided evidences that RIWP appears to have the potential to prevent inflammatory disease in lung. © 2013 Elsevier B.V. Source

Hong T.-L.,General Hospital of Shenyang Military Command | Xu K.,General Hospital of Shenyang Military Command | Jing Q.-M.,General Hospital of Shenyang Military Command | Wang S.-L.,306 Hospital of PLA | And 18 more authors.
Medical Journal of Chinese People's Liberation Army | Year: 2016

Objective To evaluate the clinical efficacy and safety of intra-aortic balloon pump (IABP) counterpulsation for the patients with acute ST-elevated myocardial infarction (STEMI). Methods To retrospectively analyze the data collected from the Management System of Cardiovascular Interventional Treatment in Military Hospitals. A total of 8878 consecutive patients with acute STEMI undergoing percutaneous coronary intervention (PCI) were recruited in present study, of whom 732 patients received IABP therapy were assigned into IABP group and the other 8146 patients received no IABP into control group. Contrastive analysis was performed to analyze the baseline data of the two groups, and 1:1 propensity matching was done to compare the differences between the two groups of intraoperative mortality, in-hospital mortality, stent thrombosis and postoperative hemorrhage. Results Multi-logistic regression revealed that age, heart failure and renal dysfunction were the risk factors for in-hospital mortality. By 1:1 propensity matching analysis, no statistical differences were found between the two groups in intraoperative mortality, postoperative hemorrhage and stent thrombosis, and the in-hospital mortality was higher in IABP group than in control group (10.4% vs 2.5%, P<0.05). Conclusion IABP can't reduce the in-hospital mortality of patients with STEMI. © 2016, People’s Military Medical Press. All rights reserved. Source

Tian T.,Beijing Jiaotong University | Wang Y.,451 Hospital of PLA | Li J.,PLA Fourth Military Medical University | Zhou F.,PLA Fourth Military Medical University | And 4 more authors.
International Journal of Clinical and Experimental Pathology | Year: 2016

GTSE1 is an important cell cycle regulatory gene and located on microtubules, which has been reported to be overexpressed in lung cancer, breast cancer and oral tongue squamous cell carcinoma etc. However, the expression of GTSE1 and its clinical pathological significance remains to be elucidated in colorectal carcinoma (CRC). Public microarray data, TCGA data and immunohistochemical staining were applied to analyze the mRNA or protein expression levels of GTSE1 in CRC. GTSE1 was found to be significantly up-regulated in 198 CRC tissues when compared with those in adjacent non-tumor tissues. Furthermore, our data showed that up-regulation of GTSE1 was associated with age, pathological tumor-node-metastasis (TNM) stage and chemotherapy. Relationship between GTSE1 expression and risk of death or recurrence were assessed by Kaplan-Meier survival curves and Cox regression model, but no notable results were obtained. We presume GTSE1 might act as a potential factor that contributes to progression of CRC. Source

Wang J.-M.,451 Hospital of PLA | Ding R.,451 Hospital of PLA | Bai X.-Y.,451 Hospital of PLA | Yuan X.-H.,451 Hospital of PLA | Li X.,451 Hospital of PLA
Chinese Journal of Medical Imaging Technology | Year: 2011

Objective: To observe the value of preoperative ultrasound in predicting possible difficulties of laparoscopic cholecystectomy (LC) in patients with acute cholecystitis. Methods: A total of 180 patients with acute cholecystitis received ultrasonography before LC. The gallbladders were comprehensively examined to observe the contour, gallbladder necks, wall thickness, wall echoes and intracyst echoes. Preoperative data and intraoperative data were compared for accessing the grade of adherence in the pericholecystic and Calot triangular area. Results: The sensitivity, specificity and accuracy of preoperative ultrasonography for predicting the grade of adherence between the gallbladder and the tissue around it was 92.78% (90/97), 93.98% (78/83) and 93.33% (168/180), respectively. Conclusion: Preoperative ultrasonography is valuable for predicting difficulties during LC in patients with acute cholecystitis. Source

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