Lagoudianakis E.,417 NIMTS Military Veterans Fund Hospital |
Pappas A.,National and Kapodistrian University of Athens |
Koronakis N.,417 NIMTS Military Veterans Fund Hospital |
Tsekouras D.,National and Kapodistrian University of Athens |
And 8 more authors.
Tumori | Year: 2011
Introduction. Adequate lymph node evaluation is an important determinant of prognosis in patients with colorectal cancer. Current guidelines recommend evaluation of at least 12 lymph nodes; however, a significant number of patients fail to meet these criteria. Aim. To investigate the factors that influence adequate recovery and evaluation of lymph nodes in colorectal cancer Methods. We retrospectively analyzed 454 consecutive cases of colorectal cancer surgically treated from September 2000 to September 2006. Univariate and multivariate linear and logistic regression analysis was used to study the effect of various factors in lymph node recovery. Results. The number of lymph nodes retrieved ranged from 0 to 62 with a median of 13 nodes. Overall, 189 (41.6%) patients had fewer than 12 nodes removed. Patient age, tumor stage, location and size were associated with lymph node retrieval. Multivariable regression revealed that the aforementioned variables, including gender and hospital type, explained 17% of the observed variance of the lymph node number. Conclusion. Patient and tumor characteristics, although important, are only partly responsible for the variation of lymph node yield. Quality of surgical resection and/or the thoroughness of examination of the tissue by the pathologist might explain the wider proportion of this variance. Training in colorectal node evaluation could help to improve the quality of cancer care. Free full text available at www.tumorionline.it.
Koukoutsis I.,01 General Army Hospital of Athens |
Gemenetzis G.,01 General Army Hospital of Athens |
Seretis C.,01 General Army Hospital of Athens |
Manouras I.,National and Kapodistrian University of Athens |
And 5 more authors.
Recent Patents on Medical Imaging | Year: 2013
Hepatectomy is the main treatment of sizable benign or malignant liver tumors (primary or metastatic). The liver remnant is essential to be adequate in both volume and function in order to avoid severe complications or morbidity of the patient. Therefore the evaluation of the liver function and the future liver volume has become of paramount importance in the preoperative patient assessment. Computed tomography has a significant contribution in the multimodality preoperative imaging of the lesion and the liver infrastructure, as well as of the liver volume. The present article reviews the existing data regarding the impact and efficacy of the patents developed to enhance the capabilities of computed tomography, in terms of evaluating liver volume, function and surgical anatomy. © 2013 Bentham Science Publishers
PubMed | Henry Dunant Hospital, 417 NIMTS Military Veterans Fund Hospital, National and Kapodistrian University of Athens and 401 Army General Hospital
Type: Journal Article | Journal: Gastroenterology research | Year: 2016
Ghrelin is an appetite hormone that influences the gastrointestinal function and regulates energy metabolism. Growing evidence also suggests that this hormone plays a central role in immune modulation. Each surgical operation is followed by a series of inflammatory and metabolic changes that constitute the stress response. The aim of our study is to evaluate the effect of stress during different types of abdominal surgery in ghrelin serum levels.An overall of 25 patients were prospectively allocated in two groups based on the type of surgical operation. Group A (n = 10) patients were scheduled to undergo cholecystectomy, whereas Group B (n = 15) patients underwent colectomy. Serum ghrelin concentrations were evaluated in each patient preoperatively, after the induction of general anesthesia and tracheal intubation, one and five hours after the beginning of surgery and the morning of the first and second postoperative day.In both groups serum ghrelin concentrations reached their peak level at 24 hr (Group A: 8.4 3.4 ng/mL; Group B: 7.4 1.8 ng/mL) and these values were significantly higher than those in the preoperative period (Group A: 5.0 1.5 ng/mL; Group B: 4.8 0.6 ng/mL) (P < 0.05). Forty eight hours after surgery the levels of ghrelin returned to their preoperative status. Patients gender, age, ASA score and type of surgical procedure did not influence the serum ghrelin levels.Serum ghrelin concentration appears to elevate in response to surgical stress. Future studies are needed to improve comprehension of the mechanisms underlying responses of this hormone to acute surgical stress and to evaluate their possible clinical implications.