Entity

Time filter

Source Type

Ymittos Athens, Greece

Dalamaga M.,National and Kapodistrian University of Athens | Polyzos S.A.,Beth Israel Deaconess Medical Center | Karmaniolas K.,417 Army Share Fund General Hospital | Chamberland J.,Beth Israel Deaconess Medical Center | And 6 more authors.
Biomarkers | Year: 2014

Context: A proteomic analysis has proposed fetuin-A (alpha-2-HS-glycoprotein) as a new potential marker for pancreatic cancer (PC).Objective: Circulating fetuin-A levels in patients with PC. Methods: Serum fetuin-A was measured in 81 cases with PC and 81 matched controls before the initiation of any treatment.Results: Serum fetuin-A was not independently associated with the presence of PC. Although there was a trend with higher fetuin-A levels across PC stages, comparisons of fetuin-A in patients within different PC prognostic stages revealed no differences.Conclusions: Circulating fetuin-A was similar between patients and controls and was not associated with the disease severity. © 2014 Informa UK Ltd. Source


Dalamaga M.,National and Kapodistrian University of Athens | Polyzos S.A.,Beth Israel Deaconess Medical Center | Karmaniolas K.,417 Army Share Fund General Hospital | Chamberland J.,Beth Israel Deaconess Medical Center | And 5 more authors.
Leukemia and Lymphoma | Year: 2015

There are limited data on fetuin-A, soluble leptin receptor (sOB-R) and free leptin index (FLI) in patients with chronic lymphocytic leukemia (CLL). The aim of this study was to compare circulating fetuin-A, sOB-R levels and FLI between 95 patients with CLL and 95 matched controls, as well as among different stages of CLL. Circulating fetuin-A was significantly lower in cases than controls (241.9 ± 99.2 vs. 288.8 ± 127.7 μg/mL; p = 0.005). Although circulating sOB-R levels were similar between groups, FLI was lower in cases than controls (0.45 ± 0.42 vs. 0.67 ± 0.57; p = 0.003). Furthermore, lower fetuin-A or FLI, but not sOB-R, were independently associated with CLL (p < 0.05), particularly among overweight/obese individuals. Fetuin-A, s-OB-R and FLI were similar between different stages of CLL severity, or between symptomatic and asymptomatic disease. In conclusion, circulating fetuin-A and FLI, but not sOB-R, were lower in patients with CLL than controls, a finding warranting further investigation. © 2015 Taylor & Francis Source

Discover hidden collaborations