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Fu L.,Chinese PLA General Hospital | Fu L.,401 Hospital of Chinese PLA | Wang R.,National Research Institute for Family Planning | Yin L.,Chinese PLA General Hospital | And 3 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

We aimed to assess the diagnostic value of the nuclear matrix protein 22 (NMP22) test in detecting bladder cancer. We searched public databases including PubMed, Springer, MEDLINE, Elsevier Science Direct, Google scholar and Cochrane Library published before September 2015. Cystoscopy and voided urine cytology (VUC) were golden standards. Sensitivity, specificity, positive likelihood ratio (LR), negative LR and diagnostic odds ratio (DOR) of NMP22 test from included studies were meta-analyzed. The summary receiver operating characteristic (SROC) curve was constructed, and the area under the curve (AUC) and an index Q* were summarized. Subgroup analyses were performed. In addition, Egger’s test was used to detect publication bias. A total of 24 studies consisting of 8848 patients with bladder cancer were included in the present meta-analysis. The results of sensitivity, specificity, positive LR, negative LR and DOR of NMP22 test were 0.71 (95% CI = 0.69 to 0.72), 0.80 (95% CI = 0.79 to 0.81), 2.99 (95% CI = 2.42 to 3.71), 0.42 (95% CI = 0.35 to 0.50) and 7.45 (95% CI = 5.32 to 10.43) respectively. The AUC and Q* index were 0.7846 and 0.7225, respectively. Subgroup analysis suggested that cutoff value might be one source of heterogeneity. Egger’s test showed that no publication bias existed (P > 0.05). The NMP22 test may be appropriate for detecting bladder cancer, but it cannot replace the cystoscopy and VUC in the clinical diagnosis. Further studies are needed to unify the cut-off value and evaluate the diagnostic efficiency of NMP22 test. © 2016, E-Century Publishing Corporation. All rights reserved.


Zhang S.,Southern Medical University | Qing Q.,Sun Yat Sen University | Wang Q.,401 Hospital of Chinese PLA | Xu J.,Southern Medical University | And 4 more authors.
Inflammatory Bowel Diseases | Year: 2013

Background: Syndecan-1 (SDC1) and its endo-beta-D-glucuronidase heparanase (HPA) are implicated in the maintenance of intestinal barrier function, but their detailed functions in Crohn's disease (CD) are not fully investigated. The aim of this study was to determine alteration patterns of SDC1 and HPA and their potential roles in evaluating disease activity and differentiating CD from intestinal tuberculosis (ITB). Methods: Tissue and serum specimens were obtained from 89 patients, including 15 patients with functional bowel disorders, 18 active patients with ITB, and 56 patients with CD (remission = 19, active = 37). Basic clinical data were collected and routine blood tests were analyzed. SDC1 and HPA were measured by immunohistochemistry, enzyme-linked immunosorbent assay, reverse transcriptase polymerase chain reaction, and western blot. Colonic epithelial cells were incubated with recombinant HPA, tumor necrosis factor alpha (TNF-a), and mycobacterium tuberculosis culture filtrate protein to detect the alterations of SDC1 and HPA. Results: In the CD group, SDC1 was significantly decreased in mucosa and increased in serum, whereas HPA level in both were elevated. Such alterations were associated with clinicopathological features representing disease activity and injury severity and were not available in functional bowel disorder and ITB groups. Recombinant HPA incubation increased soluble SDC1 in culture supernatants (P = 2 × 10-4), and low-dose TNF-a effectively enhanced HPA's activity (P = 3 × 1026). Exogenous TNF-a destroyed cellular SDC1 and raised HPA expressions dose dependently, whereas mycobacterium tuberculosis culture filtrate protein showed no effects. Conclusions: Unique alterations of SDC1 and HPA are shown in both patients with CD and in vitro model. The results indicate SDC1 and HPA are potential markers for CD in evaluating its disease activity and differentiating it from ITB. Copyright © 2013 Crohn's & Colitis Foundation of America, Inc.


Wang Y.,Chinese PLA General Hospital | Wang Y.,Nankai University | Fu L.,Chinese PLA General Hospital | Fu L.,401 Hospital of Chinese PLA | And 9 more authors.
BioMed Research International | Year: 2016

Background. Changes of N-terminal probrain natriuretic peptide (NT-proBNP) have been studied whether in the long term or the short term in patients of acute heart failure (AHF); however, changes of NT-proBNP in the first five days and their association with other factors have not been investigated. Aims. To describe the dynamic changes of relevant laboratory indexes in the first five days between different outcomes of AHF patients and their associations. Methods and Results. 284 AHF with dynamic values recorded were analyzed. Changes of NT-proBNP, troponin T, and C-reactive protein were different between patients with different outcomes, with higher values in adverse group than in control group at the same time points (p < 0.05). Then, prognostic use and risk stratification of NT-proBNP were assessed by receiver-operating characteristic curve and logistic regression. NT-proBNP levels at day 3 showed the best prognostic power (area under the curve = 0.730, 95% confidence interval (CI): 0.657 to 0.794) and was an independent risk factor for adverse outcome (odds ratio, OR: 2.185, 95% CI: 1.584-3.015). Classified changes of NT-proBNP may be predictive for adverse outcomes in AHF patients. Conclusions. Sequential monitoring of laboratory indexes within the first 5 days may be helpful for management of AHF patients. © 2016 Yurong Wang et al.


Zhao J.-Z.,Qingdao University | Song Z.-Z.,401 Hospital of Chinese PLA | Jian H.,401 Hospital of Chinese PLA | Peng X.,401 Hospital of Chinese PLA | And 3 more authors.
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

BACKGROUND: There are many risk factors for venous thromboembolism (VTE) following total hip replacement, which involves several clinical subjects. There remains no systematic and reliable evaluation system. Frequently, Doppler ultrasound has been used to identify VTE. Acute physiology and chronic health evaluation (APACHE II) has been widely used for severity degree and prognosis evaluation of ICU patients. OBJECTIVE: To evaluate the correlation between APACHE II scoring and VTE after total hip replacement. METHODS: APACHE II scores (preoperative, VTE and pulmonary thromboembolism, PTE) of 98 patients (106 hip joints) who were treated by total hip replacement in the 401 Hospital of Chinese PLA from 2000 to 2005 were analyzed retrospectively. The APACHE II scores were compared between the VTE group and non-VTE group, as well as PTE group and non- PTE group. RESULTS AND CONCLUSION: There were no significances in APACHE II scores between VTE group and non-VTE group (P > 0.05). The APACHE II scores were significantly greater in PTE group compared with non-PTE group (P < 0.05). Results show that there is no correlation between APACHE II and VTE in early stage; but the APACHE II scores were correlated with PTE following VTE. Moreover, the higher the APACHE II scores, the greater risk for PTE is.

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