Ampelokipi, Greece
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Kallianidou K.,University General Hospital | Kiakou M.,401 General Military Hospital | Tsoukalas N.,401 General Military Hospital
Archives of Hellenic Medicine | Year: 2017

Contemporary medical services are multi-dimensional and involve diverse interactions between patients and medical professionals. Every instance of care, diagnostic procedure and treatment administration presents the possibility of error. Errors inevitably occur in hospitals, the majority of which are related to medication. These errors create ethical, scientific, legal and practical issues. Nurses, who are in immediate contact with the patients, are involved in the majority of errors related to the administration of medicines. This is a review of the basic common pathways involved in medication errors, and the factors that contribute to their occurrence. © Athens Medical Society.


Chatzistefanou I.,401 General Military Hospital | Lubek J.,University of Maryland, Baltimore | Markou K.,Aristotle University of Thessaloniki | Ord R.A.,University of Maryland, Baltimore
Journal of Cranio-Maxillofacial Surgery | Year: 2017

Purpose: The role of perineural invasion (PNI) in the management of patients with oral squamous cell carcinoma (OSSC) is still controversial, and there is no consensus regarding the most appropriate therapeutic approach. The purpose of this study is to review the findings in the literature describing OSCC as a neurotropic malignancy, with the aim of correlating perineural invasion with treatment decisions and disease prognosis. Materials and methods: A literature search was conducted of references based on the MEDLINE and Cochrane Database of Systematic Reviews, with subject keywords including four main categories: perineural invasion, perineural spread, oral squamous cell cancinoma, neurotropic carcinoma. Results: In this systematic review and analysis, more than 350 publications met the eligibility criteria of the authors. Conclusion: Perineural invasion (PNI) is a widely recognized indicator of poor prognosis in oral cancer patients, strongly correlating with aggressive tumor behavior, disease recurrence, and increased morbidity and mortality. Elective neck dissection could be an indicator in improving neck control in PNI-positive patients, while the addition of adjuvant postoperative radiotherapy may not significantly improve survival rates. Various molecular markers have been correlated with perineural tumor spread, but further investigations are required before targeting PNI as part of advanced cancer therapies. © 2017 European Association for Cranio-Maxillo-Facial Surgery.


Riziotis C.,National Hellenic Research Foundation | Tsiambas E.,MycoLab | Tsiambas E.,401 General Military Hospital | Tsiambas E.,National and Kapodistrian University of Athens
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2016

A grid acting as a spatial reference and calibration aid, fabricated on glass cover slips by laser micromachining and attached on the carrier microscope slide, is proposed as a visual aid for the improvement of microscopy diagnostic procedure in the screening of cytological slides. A set of borderline and also abnormal PAP test cases -according to Bethesda 2014 revised terminology- was analyzed by conventional and grid based screening procedures, and statistical analysis showed that the introduced grid-based microscopy led to an improved diagnosis by identifying an increased number of abnormal cells in a shorter period of time, especially concerning the number of pre- or neoplastic/cancerous cells. © 2016 SPIE.


Giaginis C.,National and Kapodistrian University of Athens | Giaginis C.,University of Aegean | Tsoukalas N.,401 General Military Hospital | Bournakis E.,401 General Military Hospital | And 4 more authors.
BMC Clinical Pathology | Year: 2014

Background: Ephrin (Eph) receptors are frequently overexpressed in a wide variety of human malignant tumors, being associated with tumor growth, invasion, metastasis and angiogenesis. The present study aimed to evaluate the clinical significance of EphA1, A4, A5 and A7 protein expression in non-small cell lung carcinoma (NSCLC). Methods. EphA1, A4, A5 and A7 protein expression was assessed immunohistochemically in tissue microarrays of 88 surgically resected NSCLC and was analyzed in relation with clinicopathological characteristics and patients' survival. Results: Elevated EphA4 expression was significantly associated with low histopathological stage and presence of inflammation (p = 0.047 and p = 0.026, respectively). Elevated EphA7 expression was significantly associated with older patients' age, presence of fibrosis and smaller tumor size (p = 0.036, p = 0.029 and p = 0.018, respectively). EphA1, A5 and A7 expression were positively associated with tumor proliferative capacity (p = 0.047, p = 0.002 and p = 0.046, respectively). Elevated EphA4, A5 and A7 expression were identified as predictors of favourable patients' survival at both univariate (Log-rank test, 0 = 0.019, p = 0.006 and p = 0.012, respectively) and multivariate levels (Cox-regression analysis, p = 0.029, p = 0.068 and p = 0.044, respectively). Conclusions: The present study supported evidence that Ephs may be involved in lung cancer progression, reinforcing their utility as clinical biomarkers for patients' management and prognosis, as also as potential targets for future therapeutic interventions. © 2014 Giaginis et al.; licensee BioMed Central Ltd.


Giaginis C.,National and Kapodistrian University of Athens | Giaginis C.,University of Aegean | Alexandrou P.,National and Kapodistrian University of Athens | Tsoukalas N.,401 General Military Hospital | And 5 more authors.
Tumor Biology | Year: 2014

Hu-antigen R (HuR) is considered to play a central role in tumor formation, growth, and metastasis by binding to messenger RNAs (mRNAs) encoding proteins such as cyclooxygenase-2 (COX-2) and inducing their expression via mRNA stabilization and/or altered translation. The present study aimed to evaluate the clinical significance of HuR and COX-2 protein expression in non-small-cell lung carcinoma (NSCLC). HuR and COX-2 expression was assessed immunohistochemically on tissue microarrays of 81 surgically resected NSCLC and was analyzed in relation with clinicopathological characteristics and patients’ survival. Enhanced total HuR expression was significantly associated with tumor histological type and presence of lymph node metastases, as well as with increased tumor proliferative capacity and poor patients’ outcome (p = 0.039, p = 0.017, p = 0.033, and p = 0.022, respectively). Enhanced COX-2 expression was significantly associated with the presence of lymphovascular invasion and increased tumor proliferative capacity (p = 0.031 and p = 0.023, respectively). Concomitant elevated HuR/COX-2 expression levels were significantly associated with tumor histological type and increased proliferative capacity (p = 0.002 and p = 0.045, respectively). Enhanced total HuR expression, as well as its cytoplasmic localization, was significantly associated with increased COX-2 expression (p = 0.015 and p = 0.001, respectively). The present study supported evidence that HuR may participate in malignant transformation of NSCLC, reinforcing its usefulness as potential therapeutic target in this type of neoplasia. © 2014, International Society of Oncology and BioMarkers (ISOBM).


PubMed | University Hospital of Thessaloniki, 401 General Military Hospital, Pammakaristos General Hospital, University of Thessaly and National and Kapodistrian University of Athens
Type: | Journal: BioMed research international | Year: 2015

To identify whether the serums baseline C-reactive protein (CRP) and albumin (Alb) levels related to clinicopathological parameters and overall survival (OS) in non-small cell lung cancer (NSCLC).In total, 100 consecutive patients (mean age = 68.38 10.85 years) that underwent chemoradiotherapy were studied. Measurements of CRP and Alb were performed before any treatment.Serum CRP levels were significantly associated with histological grade (P < 0.001), TNM stage (P < 0.001), PS (P = 0.009), and Alb (P < 0.001). Additionally CRP and Alb levels were found significantly associated with overall survival in univariate analysis (log-rank test, P < 0.001 and P = 0.002, resp.) and CRP remained significant after controlling for age, alcohol, performance status, and TNM stage, whereas albumin showed a borderline effect on the hazard rate (P = 0.052).CRP and Alb are both promising biomarkers in identification of NSCLC patients with poor prognosis and form a possible target for intensifying their therapies.


Kiakou M.,401 General Military Hospital | Tolia M.,401 General Military Hospital | Tsoukalas N.,401 General Military Hospital
Archives of Hellenic Medicine | Year: 2015

Tumors occur when new cancer cells manage to escape from the surveillance of the immune system. Because of this, in recent years interest has been oriented towards immunotherapy, the objective of which is to strengthen and focus the immune response against the tumor, exploiting the unique properties of the immune system, namely, memory, potency and specificity that no drug is yet able to substitute. Major developments in the field of cancer immunology have already provided the knowledge and techniques required to develop novel immunotherapeutic approaches, specifically active, passive and adoptive immunotherapy. Although induction of the anti-tumor response through vaccination (active immunotherapy) would appear to be theoretically logical and expected to be successful, the application of tumor-specific monoclonal antibodies has demonstrated clearer evidence of objective clinical responses in patients who received them. Recently a new immunotherapeutic cancer approach has been developed, called chimeric antigen receptor therapy (CAR) therapy. This article summarizes the most promising approaches to cancer immunotherapy currently being applied and studied. The gates for the transition to the era of immunotherapy have already been opened, as recent clinical successes signal the beginning of the evolution of cancer immunotherapy from the experimental phase to established therapy. © Athens Medical Society.


PubMed | 401 General Military Hospital
Type: Journal Article | Journal: Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG | Year: 2017

Not available.


PubMed | 401 General Military Hospital
Type: Journal Article | Journal: World journal of gastrointestinal oncology | Year: 2016

Neuroendocrine tumors of the gastrointestinal tract are rare neoplasms. Rectal neuroendocrine tumors consist approximately the 5%-14% of all neuroendocrine neoplasms in Europe. These tumors are diagnosed in relatively young patients, with a mean age at diagnosis of 56 years. Distant metastases from rectal neuroendocrine tumors are not very common. Herein we describe a case of a rectal neuroendocrine tumor which metastasized to the lung, mediastinum and orbit. This case underscores the importance of early identification and optimal management to improve patients prognosis. Therefore, the clinical significance of this case is the necessity of physicians awareness and education regarding neuroendocrine tumors diagnosis and management.


Panagiotou I.,401 General Military Hospital | Sampaziotis D.,401 General Military Hospital | Kotoulas C.,401 General Military Hospital
Interactive Cardiovascular and Thoracic Surgery | Year: 2012

Alveolar adenoma is an extremely rare benign tumour of the lung. Less than 30 cases have been reported in the English literature. A 42-year-old asymptomatic female who presented with a solitary peripheral pulmonary nodule on chest roentgenogram underwent thoracoscopic wedge resection and was diagnosed with this rare tumour. The indolent clinical progression and the absence of recurrence and metastasis after complete resection are the most important characteristics of this tumour. The classical solitary pulmonary nodule is a common and vexing problem. Nodules are extremely common in clinical practice and challenging to manage. Solitary pulmonary nodules can represent different specific lung diseases, focal non-specific inflammations, and primary and secondary malignant tumours. Identification of malignant nodules is important because they represent a potentially curable form of lung cancer. © The Author 2012.

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