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‘Arad, Israel

Karpas Z.,3QBD Ltd. | Karpas Z.,Nuclear Research Center - Negev
International Journal for Ion Mobility Spectrometry | Year: 2012

With a background in mass spectrometric studies of gas-phase ion chemistry the atmospheric pressure technology of ion mobility spectrometry (IMS) presented me with challenges and opportunities. Fundamental studies of the parameters that influence the mobility of ions in a low electric field yielded insights about the effects of temperature, drift gas composition and the conformation of ions on the collision cross section. The inadequacy of current rigid-sphere, polarization limit and hard-core models to predict the mobility of ions particularly at low temperature and in heavy drift gases, led to inclusion of additional terms to the hard-core model to account for these effects. These studies eventually resulted in the two monographs entitled "Ion Mobility Spectrometry" and "Ion Mobility Spectrometry -Second Edition" co-authored with Prof. Gary Eiceman and published by Taylor & Francis, CRC Press in 1994 and 2005, respectively. Novel applications for biological and medical applications were developed on the basis of measurement of biogenic amines by IMS, in particular the rapid, accurate and inexpensive diagnosis of vaginal infections. © 2011 Springer-Verlag.

Sobel J.D.,Wayne State University | Karpas Z.,3QBD Ltd. | Karpas Z.,Nuclear Research Center - Negev | Lorber A.,Nuclear Research Center - Negev
European Journal of Obstetrics Gynecology and Reproductive Biology | Year: 2012

Objective: To compare diagnosis of bacterial vaginosis according to the Amsel criteria with measurement by ion mobility spectrometry (IMS) of the biogenic amines that are present in vaginal discharge fluid. Study design: Duplicate samples of vaginal fluid were collected from 115 unselected and consecutive patients in a vaginitis clinic in Detroit. All samples were evaluated using Amsel criteria and the results were compared with the diagnosis based on the IMS results. Results: The incidence rate of vaginal infections was assessed on the basis of both tests and the frequency of BV was found to be 17.4%. The sensitivity and specificity for bacterial vaginosis diagnosis using IMS determination were 95.5% and 98.9%, respectively, with an accuracy of 94.4%. Conclusions: The results show that IMS may be used to rapidly diagnose this common vaginal infection with high accuracy. © 2012 Elsevier Ireland Ltd. All rights reserved.

Karpas Z.,Nuclear Research Center - Negev | Karpas Z.,3QBD Ltd.
Food Research International | Year: 2013

Several new and innovative applications of ion mobility spectrometry (IMS) and related technologies in the field of foodomics have emerged in the last decade. Among these are the assessment of food freshness or the degree of spoilage of muscle food products, the determination of the level of odorants in wine responsible for the "off flavor", the detection of traces of harmful chemicals and drug residues in food products, classification of olive oil grades and detection of adulteration of agricultural products, detection of pathogenic micro-organisms or toxins and other applications. In view of the rapid response, high sensitivity, simplicity and low price of analysis by IMS it is reasonable to predict that its utilization in food quality and food safety will increase in the following years. This work presents a review of the advances that have been made in the last few years and demonstrates the potential of the technique in the field of foodomics. © 2012 Elsevier Ltd.

Blankenstein T.,Ludwig Maximilians University of Munich | Lytton S.D.,SeraDiaLogistics | Leidl B.,Ludwig Maximilians University of Munich | Atweh E.,3QBD Ltd. | And 2 more authors.
Archives of Gynecology and Obstetrics | Year: 2015

Purpose: A new CE-marked portable desktop ion mobility spectrometer (VGTest) was used for detection of malodorous biogenic amines indicative of bacterial vaginosis (BV). This study aimed to assess the performance of this testing method for the first time in a routine ambulatory care clinic and to determine the relative levels of biogenic amines in vaginal fluid of BV. Methods: Vaginal and cervical swabs (n = 57) were surveyed for infections. Cases of BV (n = 18) confirmed positive according to “Amsel” criteria and normal controls (n = 39) showing no infection under clinical examination and testing negative in wet mount microscopy were included in the IMS analysis. Results: The trimethylamine (TMA) content in vaginal fluid of the BV-positive cases, AUCTMA/AUCTotal [mean 0.215 (range 0.15–0.35)] was significantly higher than normal controls [mean 0.06 (range 0.048–0.07)] p < 0.0001. The putrescine (1,4-diaminobutane, PUT) and cadaverine (1,5-diaminopentane, CAD) of BV-positive cases were above controls at borderline significance. The AUCTMA/AUCTotal ratios correlated neither with AUCPUT/AUCTotal nor AUCCAD/AUCTotal among BV-positive patients. In contrast, among normal controls all the biogenic amines were at a low level and the linear regression analysis revealed striking positive correlations of AUCTMA/AUCTotal with AUCPUT/AUCTotal (p < 0.05) and AUCCAD/AUCTotal (p < 0.001). The test shows 83 % sensitivity and 92 % specificity at a cut-off of AUCTMA/AUCTotal = 0.112 and AUC of receiver operator characteristic = 0.915 (0.81–0.97, 95 % CI). Conclusions: VGTest-IMS is accurate and feasible for point-of-care testing of BV in the ambulatory care setting. Further evaluations are in progress to assess the utility of VGTest-IMS for differential diagnosis of candidosis, non-BV infection and common inflammatory conditions. © 2015, Springer-Verlag Berlin Heidelberg.

3QBD Ltd. | Date: 2014-05-04

Apparatus and instruments for diagnosing vaginal infections.

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