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South Apopka, FL, United States

Milam J.A.,3D Imaging Inc.
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2010

Commercial, forensic, and military divers often encounter turbid conditions which reduce visibility to zero. Under such conditions, work must be performed completely blind. The darkness resulting from high levels of turbidity is complete, and can be dangerous as well as disorienting. Such darkness can even occur near the surface on a bright and sunny day. Artificial underwater lighting is of no use in such situations, as it only makes matters worse (similar to the use of high beam headlights in dense fog). Certain wavelengths of infrared (IR) light have the ability to penetrate this underwater "fog," and thus form the basis of the current development. Turbidity results from clay, silt, finely divided organic and inorganic matter, soluble colored organic compounds, plankton and microscopic organisms suspended in water. The IR Diver Vision system described herein consists of a standard commercial diving mask of any of several configurations whereby an IR light source, IR video camera, video display, and power source may be integrated within or attached to the mask. The IR light source wavelength is compatible with the spectral bandwidth of the video camera. The camera field-of-view (FOV) is matched to the video display in order to provide a unity magnification and hence prevent diver ocular fatigue. The IR video camera, video display, power source and controls are compatible with extended use in a submarine environment. Some such masks will incorporate tilt/heading sensors and video indicators. 3-D Imaging, Inc. has developed prototypes and has patents pending on such devices. © 2010 Copyright SPIE - The International Society for Optical Engineering. Source


Apana S.M.,3D Imaging Inc. | Berridge M.S.,3D Imaging Inc. | Berridge M.S.,University of Arkansas for Medical Sciences | Berridge M.S.,Case Western Reserve University
Journal of Labelled Compounds and Radiopharmaceuticals | Year: 2010

The ultimate goal of this work was to relate nicotine kinetics in the brain after cigarette smoking to a feature of sensitization in drug addiction. To do this required a positron emission tomography study to measure the regional cerebral biodistribution kinetics of cigarette-smoked nicotine. This in turn required a cigarette formulated with carbon-11 labeled nicotine suitable for administration by single bolus inhalation. Here we report the development and validation of cigarettes formulated with [11C]nicotine that were successfully used for single bolus administration by smoking. We also report measurements of nicotine delivery from smoked cigarettes. Copyright © 2009 John Wiley & Sons, Ltd. Source


Apana S.M.,3D Imaging Inc. | Anderson L.W.,Center for Drug Evaluation and Research | Berridge M.S.,3D Imaging Inc. | Berridge M.S.,University of Arkansas for Medical Sciences
Journal of Labelled Compounds and Radiopharmaceuticals | Year: 2010

SN-38 (7-ethyl-10-hydroxy camptothecin) is a topoisomerase I inhibitor that is the active chemotherapeutic agent of irinotecan, indicated for colon cancer. Because the rate of response to irinotecan treatment is low, it is of interest to have a prognostic indicator to identify and more selectively treat those who are likely to respond to treatment. We have therefore prepared SN-38 labeled with carbon-11. SN-38 was prepared by radical oxidation of 3-[ 11C]propionaldehyde and subsequent radical addition of the ethyl fragment to 10-hydroxycamptothecin. Labeled propionaldehyde was prepared by reaction of methyl iodide with 2-lithiomethyl-1,3-dioxolane. Overall chemical yield was 34% from carbon dioxide. The murine biodistribution and radiation dosimetry of [11C]SN-38 was measured by PET scanning in preparation for initial human studies. Biodistribution was fairly uniform except for hepatobiliary and urinary excretion. Copyright © 2010 John Wiley & Sons, Ltd. Source


Apana S.M.,3D Imaging Inc. | Griffin R.J.,University of Arkansas for Medical Sciences | Koonce N.A.,University of Arkansas for Medical Sciences | Webber J.S.,University of Arkansas for Medical Sciences | And 4 more authors.
Journal of Labelled Compounds and Radiopharmaceuticals | Year: 2011

Anginex is a 33-residue peptide that has been previously demonstrated to possess antiangiogenic properties. To provide a tool to evaluate the regional biodistribution and pharmacokinetics of anginex, and possibly to provide a useful angiogenesis-targeted radiotracer, we have radiolabeled anginex with fluorine-18. High specific activity [ 18F]fluorobenzaldehyde (1.5-4.8 TBq (40-130 Ci)/μmol) was used to label anginex via reductive amination in 76% yield. The effective specific activity of the product was lower because unlabeled anginex was not separated. However, the high specific activity labeling reagent increased the labeling yield and reduced the amount of anginex required for labeling. Regional pharmacokinetics were measured by PET scanning in mice, demonstrating tumor uptake and low background, with up to 30% of total injected dose localized in some tumors. Copyright © 2011 John Wiley & Sons, Ltd. Source

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