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Jackson, MN, United States

Gopinath T.,321 Church St. SE | Veglia G.,321 Church St. SE
Angewandte Chemie - International Edition | Year: 2012

Fast data collection: A general method for dual data acquisition of multidimensional magic-angle spinning solid-state NMR experiments is presented (see picture). The method uses a simultaneous Hartmann-Hahn cross-polarization from 1H to 13C and 15N nuclei and exploits the long-living 15N polarization for parallel acquisition of two multidimensional experiments. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Kuroki M.T.,321 Church St. SE | Kuroki M.T.,University of Minnesota | Guzman P.A.,321 Church St. SE | Fink G.D.,Michigan State University | And 2 more authors.
American Journal of Physiology - Heart and Circulatory Physiology | Year: 2012

Previous studies suggest that ANG II-induced hypertension in rats fed a high-salt (HS) diet (ANG II-salt hypertension) has a neurogenic component dependent on an enhanced sympathetic tone to the splanchnic veins and independent from changes in sympathetic nerve activity to the kidney or hind limb. The purpose of this study was to extend these findings and test whether altered autonomic control of splanchnic resistance arteries and the heart also contributes to the neurogenic component. Mean arterial pressure (MAP), heart rate (HR), superior mesenteric artery blood flow, and mesenteric vascular resistance (MVR) were measured during 4 control days, 14 days of ANG II delivered subcutaneously (150 ng ·kg -1 ·min -1), and 4 days of recovery in conscious rats fed a HS (2% NaCl) or low-salt (LS; 0.1% NaCl) diet. Autonomic effects on MAP, HR, and MVR were assessed by acute ganglionic blockade with hexamethonium (20 mg/kg iv) on day 3 of control, days 1, 3, 5, 7, 10, and 13 of ANG II, and day 4 of recovery. MVR increased during ANG II infusion in HS and LS rats but remained elevated only in HS rats. Additionally, the MVR response to hexamethonium was enhanced on days 10 and 13 of ANG II selectively in HS rats. Compared with LS rats, HR in HS rats was higher during the 2nd wk of ANG II, and its response to hexamethonium was greater on days 7, 10, and 13 of ANG II. These results suggest that ANG II-salt hypertension is associated with delayed changes in autonomic control of splanchnic resistance arteries and the heart. Salt-sensitive hypertension; differential regulation of sympathetic outflow; splanchnic nerve activity; ganglionic blockade; hemodynamic measurement in conscious rats; angiotensin II. © 2012 the American Physiological Society.

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