Hospital 307 of PLA

Beijing, China

Hospital 307 of PLA

Beijing, China
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Bian H.,PLA Fourth Military Medical University | Zheng J.-S.,Capital Medical University | Nan G.,PLA Fourth Military Medical University | Li R.,Capital Medical University | And 15 more authors.
Journal of the National Cancer Institute | Year: 2014

To assess the efficacy of combining radioimmunoconjugate [131I] metuximab with radiofrequency ablation (RFA) in hepatocellular carcinoma (HCC) treatment compared with RFA alone, a single-center randomized controlled trial was conducted on 127 patients with Barcelona Clinic Liver Cancer staging system (BCLC) classifications of 0-B stage. Patients received either RFA followed by [131I] metuximab (n = 62) or RFA alone (n = 65). The primary outcome was overall tumor recurrence. Statistical tests were two-sided. The one- and two-year recurrence rates in the combination group were 31.8% and 58.5%, whereas those in the RFA group were 56.3% and 70.9%, respectively. The median time to overall tumor recurrence was 17 months in the combination group and 10 months in the RFA group (P =.03). The RFA-[131I] metuximab treatment showed a greater antirecurrence benefit than RFA in the metuximab target (ie, CD147)-positive subpopulation (P =.007). [131I] metuximab may yield prevention of tumor recurrence after RFA. © The Author 2014. Published by Oxford University Press. All rights reserved.

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