307 Hospital of Chinese PLA

Fengtai, China

307 Hospital of Chinese PLA

Fengtai, China
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Qian Z.,Beihang University | Qian Z.,Chinese Institute of Basic Medical Sciences | Wang H.,307 Hospital of Chinese PLA | Tuo X.,First Affiliated Hospital of PLA General Hospital | And 7 more authors.
Journal of Materials Chemistry B | Year: 2017

Controlling severe hemorrhages remains a challenge. Successful hemorrhage control depends on the speed and quality of blood clot formation. Fast deprivation of water from blood leads to the concentration of blood cells and coagulation factors and thus triggers blood clot formation. This inspired us to develop a new hemostatic material. In this study, we grafted sodium polyacrylate (SPA) onto the backbone of chitosan (CTS) and crosslinked with methacrylic anhydride-modified polyethylene glycol (MAAPEG) to provide a flexible and elastic inter-chain connection between SPA and CTS chains in the presence of a blowing agent to achieve a porous structure. By a simple one-pot reaction, we fabricated a soft, elastic porous xerogel sponge that could reach maximum water absorbency of 180 in less than 200 seconds. This SPA-co-chitosan xerogel sponge demonstrated superior hemostatic properties in thromboelastography (TEG®) test and in a rabbit lethal extremity arterial bleeding model as compared to zeolite granules, kaolin gauze, and chitosan granules. Furthermore, this hemostat worked as a whole to transfer external pressure to the bleeding area and was adhesive to wet wound tissue to seal the bleeding site. In general, the SPA-co-CTS sponge demonstrates a fast and powerful hemostatic effect both in vitro and in vivo, which is superior over the existing commercial products. It might be a promising first-aid device for severe hemorrhage control. © 2017 The Royal Society of Chemistry.


Sun J.-Z.,General Hospital of PLA | Lu Y.,307 Hospital of Chinese PLA | Fu Y.,General Hospital of PLA | Du N.,General Hospital of PLA | Xiao W.-H.,General Hospital of PLA
Chinese Journal of Cancer Prevention and Treatment | Year: 2010

OBJECTIVE: To investigate the effect of ATF-Fc, an engineering molecule on tumor growth and metastasis. METHODS: ATF-Fc, an antibody-like molecule comprising the amino-terminal fragment of human uPA (ATF) linked to the Fc fragment of human IgG1 via a flexible linker was developed. Its antitumor activities were evaluated in vitro and in vivo. RESULTS: The results showed that ATF-Fc had obvious cytotoxic effects on several types of tumor cells, which was dependent on the expression of uPAR and the Fc fragment. Treatment with ATF-Fc caused a significant reduction in tumor volume and weight in athymic nude mice s. c. implanted with human MCF-7 breast cancer cells or BGC-823 gastral cancer cells. The inhibition rate of ATF-Fc on MCF-7 and BGC-823-bearing nude mice were 84% and 74%, respectively. The number of liver metastasis and the number of metastatic foci were significantly reduced in mice treated with ATF-Fc, P<0.001. CONCLUSION: ATF-Fc is a novel therapeutic antibody in the management of solid tumors by disrupting the uPA/uPAR interaction.


Huang C.,307 Hospital of Chinese PLA | Zhang X.,307 Hospital of Chinese PLA | Jiang Y.,307 Hospital of Chinese PLA | Li G.,307 Hospital of Chinese PLA | And 3 more authors.
Toxicology and Industrial Health | Year: 2013

Paraquat (PQ) is a potent toxicant for humans, and poisoning with PQ is associated with high mortality. Patients with severe PQ-induced poisoning may die of multiple organ failure involving the circulatory and respiratory systems. Death resulting from epilepsy-like convulsions, which are infrequently noted reported with PQ poisoning, is observed clinically with this condition. This study presents the clinical data of five patients with severe PQ-induced poisoning who died of epilepsy-like convulsions, and related publications were reviewed in order to investigate the pathogenesis, clinical manifestations, and prognosis of these convulsions. Our results may help prevent this event and improve the success of treatment. © The Author(s) 2012.


PubMed | 307 Hospital of Chinese PLA
Type: Case Reports | Journal: Toxicology and industrial health | Year: 2013

Paraquat (PQ) is a potent toxicant for humans, and poisoning with PQ is associated with high mortality. Patients with severe PQ-induced poisoning may die of multiple organ failure involving the circulatory and respiratory systems. Death resulting from epilepsy-like convulsions, which are infrequently noted reported with PQ poisoning, is observed clinically with this condition. This study presents the clinical data of five patients with severe PQ-induced poisoning who died of epilepsy-like convulsions, and related publications were reviewed in order to investigate the pathogenesis, clinical manifestations, and prognosis of these convulsions. Our results may help prevent this event and improve the success of treatment.

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