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Beijing, China

Li H.,China Pharmaceutical University | Mao S.,China Pharmaceutical University | Wang H.,306th Hospital of PLA | Zen K.,China Pharmaceutical University | And 2 more authors.
Protein and Cell | Year: 2014

MicroRNAs (miRNAs) are endogenously expressed small, non-coding transcripts that regulate protein expression. Substantial evidences suggest that miRNAs are enriched in central nervous system, where they are hypothesized to play pivotal roles during neural development. In the present study, we analyzed miRNAs expression in mice cerebral cortex and hippocampus at different developmental stages and found miR-29a increased dramatically at postnatal stages. In addition, we provided strong evidences that miR-29a is enriched in mature neurons both in vitro and in vivo. Further investigation demonstrated that the activation of glutamate receptors induced endogenous miR-29a level in primary neurons. Moreover, we showed that miR-29a directly regulated its target protein Doublecortin (DCX) expression, which further modulated axon branching in primary culture. Together, our results suggested that miR-29a play an important role in neuronal development of mice cerebrum. © 2014 The Author(s). Source


Li J.,General Hospital of Beijing Military Command | Yang G.-Z.,General Hospital of Beijing Military Command | Zhu Z.-M.,304th Hospital of PLA | Zhou Z.-Y.,306th Hospital of PLA | Li L.,General Hospital of Beijing Military Command
Experimental and Therapeutic Medicine | Year: 2012

Osteopontin (OPN), a secreted phosphorylated glycoprotein, has been found to be involved in carcinogenesis, progression and metastasis of several types of cancers. The aim of the present study was to investigate the immunohistochemical expression of OPN in colorectal carcinoma (CRC) and its relationship with clinicopathological parameters and P53. Expression of OPN, Ki-67 and TP53 was detected in 77 cases of CRC by immunohistochemistry and the correlation of the expression of OPN with clinicopathological features, Ki-67 and P53 staining was investigated. Thirty-eight cases (49.4%) of CRC demonstrated OPN overexpression. Overexpression of OPN was associated with lymph node metastasis (P=0.025) and Dukes' stages (P=0.031), but not with gender, histological differentiation, depth of tumor invasion, TNM stages or Ki-67 index. The correlation between expression of OPN and TP53 was statistically significant (P=0.030). In conclusion, OPN is overexpressed in CRC, and plays a role in tumor progression and metastasis, which is possibly regulated by P53. Source


Wang B.,Unit No. 92060 of PLA | Pei Z.,306th Hospital of PLA | Wang L.,Peking University
EPL | Year: 2014

The world in which we are living is a huge network of networks and should be described by interdependent networks. The interdependence between networks significantly affects the evolutionary dynamics of cooperation on them. Moreover, due to the diversity and complexity of social and biological systems, players on different networks may engage in different forms of interactions, which should be described by multiple game models in the evolutionary game theory, such as the Prisoner's Dilemma and Snowdrift Game. We therefore study the evolutionary dynamics of cooperation on two interdependent networks playing different games, respectively. We show that, with the increment of network interdependence, the evolution of cooperation is dramatically promoted on the network playing Prisoner's Dilemma, and the cooperation level of the network playing Snowdrift Game reduces correspondingly. Remarkably, there exists an optimal intermediate region of network interdependence maximizing the growth rates of cooperation on the network playing Prisoner's Dilemma. Also on the network playing Prisoner's Dilemma, players contacting with the other network have an advantage in the evolution of cooperation over the other players on the same network, which is contrary to the network playing Snowdrift Game. Copyright © EPLA, 2014. Source


Wang Y.X.,Capital Medical University | Hu L.N.,306th Hospital of PLA | Yang H.,Capital Medical University | Jonas J.B.,Capital Medical University | And 2 more authors.
British Journal of Ophthalmology | Year: 2012

Background: To examine factors associated with progression of open-angle glaucoma in a population-based setting. Methods: The population-based Beijing Eye Study, which included 4439 subjects with an age of 40+ years in the year 2001, was repeated in 2006. Optic disc photographs of the baseline examination versus follow-up examination were compared. Results: Out of 111 open-angle glaucoma patients examined in 2001, 77 (69%) subjects participated in the follow-up examination and 16 (21%) eyes showed glaucoma progression. Glaucoma progression was associated with smaller rim area (p=0.001), larger β zone (p=0.037), higher frequency of β zone increase during follow-up (p=0.01), higher prevalence of disc haemorrhages (p=0.01) and higher single intraocular pressure (p=0.04). In multiple regression analysis, only smaller rim area remained significantly associated with glaucoma progression. Glaucoma progression was not associated with optic disc size (p=0.70), mean blood pressure (p=0.43), ocular perfusion pressure (p=0.96), retinal vessel diameter and retinal microvascular abnormalities (all p>0.10), prevalence of diabetes mellitus (p=0.75) and arterial hypertension (p=0.26), prevalence of dyslipidaemia (p=0.28), refractive error (p=0.69), and central corneal thickness (p=0.97). Conclusions: In a population-based setting in adult Chinese, factors showing an association with open-angle glaucoma progression were an advanced stage of the disease (ie, small rim), presence of disc haemorrhages, larger area of β zone and higher frequency of β zone increase, and higher intraocular pressure. Glaucoma progression was not significantly associated with optic disc size, central corneal thickness, retinal vessel diameter and retinal microvascular abnormalities, and systemic diseases such as diabetes mellitus and arterial hypertension. Source


Liang W.,Shaoxing Peoples Hospital | Gao B.,306th Hospital of PLA | Fu P.,Tongji University | Xu S.,Shanghai University | And 2 more authors.
Frontiers in Bioscience | Year: 2013

Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. MicroRNAs (miRNAs) are non-coding small RNAs, usually 18-25 nucleotides in length, which repress translation and cleave mRNA by base-pairing to the 3 untranslated region of the target genes. miRNAs have demonstrated far-reaching effects on the cellular biology of development and cancer. Their role in osteosarcomagenesis remains largely unexplored. A number of reports have investigated the role of microRNAs in osteosarcoma. This review summeizes the recent research progress of miRNA in the osteosarcome. Source

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