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Beijing, China

Objective: To evaluate the effect of decoction of turtle shell for anti-fibrosis combined with stronger neo-minophagen C on the indices of hepatic fibrosis in chronic hepatitis B. Method: The 94 cases of chronic viral hepatitis B patients were randomly divided into two groups. The treatment group was treated with stronger neo-minophagen C 100 mL dissolved in 10% dextrose 250ml once a day intravenously, combined with decoction of turtle shell for anti-fibrosis one powder daily. And the control group was treated with stronger neo-minophagen C alone, 3 months as a course. Liver fibrosis indexes and liver function index were tested for two groups of patients before and after the treatment. Result: Both the difference of liver fibrosis indexes between the treatment group and the control group and before and after the treatment in the treatment group had statistical significance (P <0.01). Both the difference of liver function index between the treatment group and the control group and before and after the treatment in the treatment group had statistical significance (P < 0.01). The basic cure rate and total effective rate were 40% and 84.0% in the treatment group and 27.27% and 86.18% in the control group respectively with significant difference. The treatment group was superior to control group in the mean size of diameter of portal vein and the thickness of spleen (P < 0.01). Conclusion: Decoction of turtle shell for anti-fibrosis combined with stronger neo-minophagen C could significantly improve the clinical efficacy and the liver fibrosis indexes and liver function index in chronic hepatitis B. Source

Li J.-W.,Chongqing Medical University | Xu C.,305 Hospital of PLA | Fan Y.,Chongqing Medical University | Wang Y.,Chongqing Medical University | Xiao Y.-B.,Chongqing Medical University

Background: It is demonstrated that elevated serum levels of alkaline phosphatase (ALP) and phosphate indicate a higher risks of cardiovascular disease (CVD) and total mortality in population with chronic kidney disease (CKD), but it remains unclear whether this association exists in people with normal or preserved renal function. Method: Clinical trials were searched from Embase and PubMed from inception to 2013 December using the keywords "ALP", "phosphate", "CVD", "mortality" and so on, and finally 24 trials with a total of 147634 patients were included in this study. Dose-response and semi-parametric meta-analyses were performed. Results: A linear association of serum levels of ALP and phosphate with risks of coronary heart disease (CHD) events, CVD events and deaths was identified. The relative risk(RR)of ALP for CVD deaths was 1.02 (95% confidence interval [CI], 1.01-1.04). The RR of phosphate for CVD deaths and events was 1.05 (95% CI, 1.02-1.09) and 1.04 (95% CI: 1.03-1.06), respectively. A non-linear association of ALP and phosphate with total mortality was identified. Compared with the reference category of ALP and phosphate, the pooled RR of ALP for total mortality was 1.57 (95% CI, 1.27-1.95) for the high ALP group, while the RR of phosphate for total mortality was 1.33 (95% CI, 1.21-1.46) for the high phosphate group. It was observed in subgroup analysis that higher levels of serum ALP and phosphate seemed to indicate a higher mortality rate in diabetic patients and those having previous CVD. The higher total mortality rate was more obvious in the men and Asians with high ALP. Conclusion: A non-linear relationship exists between serum levels of ALP and phosphate and risk of total mortality. There appears to be a positive association of serum levels of ALP/phosphate with total mortality in people with normal or preserved renal function, while the relationship between ALP and CVD is still ambiguous. © 2014 Li et al. Source

Huang X.N.,Capital Normal University | Li W.,Capital Normal University | He W.,305 Hospital of PLA
Advanced Materials Research

A novel pH sensitive cadmium sulfide quantum dot (CdS QD) was prepared by a coprecipitation method in the presence of pH sensitive poly(2-(dimethylamino)ethyl methacrylate)-co- poly(2-(dibutylamino)ethyl methacrylate)(PDMA-PDBA) copolymer. CdCl2 and Na2S were mixed in aqueous media in the presence of PDMA-PDBA. The amine groups of PDMA were anchored on the surface of the formed CdS nanoparticles, whereas the PDBA segment was anchored on the surface to form a hydrophilic palisade at low pH environment, thus turn on the fluorescence CdS QD probe; at high pH value, PDBA segments precipitate and turn off fluorescence because of the phase separation. This novel pH sensitive fluorescene CdS QDs probe have great application potential for target imaging of cancer. © (2014) Trans Tech Publications, Switzerland. Source

Hu G.,Medical College | Lin M.,Peoples Hospital of Chang Shan | Chang Y.,305 Hospital of PLA
Zhongguo Zhongyao Zazhi

Objective: To discuss the effect of integrated traditional Chinese and Western medicine on Th1/Th2 cytokines level in children with asthma. Method: Children with asthma were randomly divided into control group and treatment group. The control group was given Montelukast Sodium tablets for 4 mg (2-5 years old) or 5 mg (6-14 years old), once every night before sleeping. At the same time, the treatment group was given Pingchuan water decoction additionally for one tie per day , in four to six-divided doses for eight weeks. On the other hand, groups of health children were selected as blank control. Before and after treatment, the level of IL-4, IL-13 and IFN-γ were detected by elisa from 3 mL of venous blood. Result: Before treatment, IL-4 and IL-13 in two groups were obviously higher than healthy group, but IFN-γ was lower (P <0.01, P <0.05). After eight weeks, IL-4 and IL-13 in treatment group went down, but IFN-γ increased. And there were significant different compared with the control group (P < 0.05). Conclusion: Treating children asthma by integrated traditional Chinese and western medicine can obviously reduce IL-4 and IL-13, increase IFN-γ, and therefore lighten the airway inflammation, prevent asthma attacks effectively. Source

Zhai W.,Chinese PLA General Hospital | Huang Z.,305 Hospital of PLA | Chen L.,Chinese PLA General Hospital | Feng C.,Chinese PLA General Hospital | And 2 more authors.

Phthalates are extensively used as plasticizers in a variety of daily-life products, resulting in widespread distribution in aquatic environments. However, limited information is available on the endocrine disrupting effects of phthalates in aquatic organisms. The aim of the present study was to examine whether exposure to mono-(2-ethylhexyl) phthalate (MEHP), the hydrolytic metabolite of di-(2-ethylhexyl) phthalate (DEHP) disrupts thyroid endocrine system in fish. In this study, zebrafish (Danio rerio) embryos were exposed to different concentrations of MEHP (1.6, 8, 40, and 200 mg/L) from 2 h post-fertilization (hpf) to 168 hpf. The whole-body content of thyroid hormone and transcription of genes involved in the hypothalamic-pituitary-thyroid (HPT) axis were examined. Treatment with MEHP significantly decreased whole-body T4 contents and increased whole-body T3 contents, indicating thyroid endocrine disruption. The upregulation of genes related to thyroid hormone metabolism (Dio2 and UGT1ab) might be responsible for decreased T4 contents. Elevated gene transcription of Dio1 was also observed in this study, which might assist to degrade increased T3 contents. Exposure to MEHP also significantly induced transcription of genes involved in thyroid development (Nkx2.1 and Pax8) and thyroid hormone synthesis (TSHβ, NIS and TG). However, the genes encoding proteins involved in TH transport (transthyretin, TTR) was transcriptionally significantly down-regulated after exposure to MEHP. Overall, these results demonstrate that acute exposure to MEHP alters whole-body contents of thyroid hormones in zebrafish embryos/larvae and changes the transcription of genes involved in the HPT axis, thus exerting thyroid endocrine toxicity. © 2014 Zhai et al. Source

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