301 Military General Hospital

Haidian District, China

301 Military General Hospital

Haidian District, China
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Chen W.,301 Military General Hospital | Li M.,301 Military General Hospital | Fang X.,301 Military General Hospital | Fan Q.,301 Military General Hospital | Yu M.,301 Military General Hospital
Journal of Cancer Science and Therapy | Year: 2012

Objectives: To explore efficacy and safety of bronchial arterial infusion of recombinant adenovirus p53 gene (rAd-p53, or Gendicine ®) in treatment of multiple lung metastases tumor from Hepatocellular Carcinoma (HCC). Methods: Thirty two patients with HCC and multiple pulmonary metastases were included in this study. Lung metastatic tumors were treated using bronchial arterial infusion of rAd-p53 via a transcatheter. Two infusions, once per week, were given to each lung area containing metastatic tumors at a dose of 2-4 × 10 12 Virus Particles (VP) per infusion. All these patients were followed up every 3 month. Spiral CT was performed during follow-up visits to monitor tumor progress. Results: At 3 months after the last treatment, 6 patients showed lung metastatic tumors completely disappeared, 15 patients showed a decrease in number of tumors, 2 patients un-changed in tumor number, and 9 patients developed new metastatic tumors. Overall survival rate of one year was 93.7% and median survival time was 18.4 months. There were no serious adverse events except for self-limited fever (38° C-39.5° C) was found in 28 patients. Conclusions: Bronchial arterial infusion of rAd-p53 is an effective and safe in treatment of multiple lung metastatic tumors of HCC. © 2012 Chen W, et al.


Liu S.,Nankai University | Chen P.,301 Military General Hospital | Hu M.,301 Military General Hospital | Tao Y.,301 Military General Hospital | And 5 more authors.
Cancer Gene Therapy | Year: 2013

The aim of this study is to evaluate clinical benefits of recombinant adenoviral human p53 (rAd-p53) gene therapy combined with radiotherapy in prevention of oral cancer recurrence after a radical resection. A total of 51 patients with tongue cancer (TCa) and 56 patients with gingival carcinoma (GCa) satisfying the inclusion criteria were randomly assigned to two groups: the experiment group (EG) and the control group (CG). The EG group received multipoint injections of rAd-p53 into the surgical wound surface at a dose of 1 × 1012 viral particles after a radical resection. Patients in both EG and CG were given radiotherapy at a total dose of 60 Gy at 3 weeks after surgery. All these patients were followed up for at least 3 years. Two cases (2/27) of TCa and 2 (2/30) in GCa patients had a local recurrence in EG, but 8 (8/24) TCa and 8 (8/26) GCa patients in CG had a local recurrence. Both recurrent rates of TCa (33.3%) and GCa (30.8%) in CG are statistically significantly higher than those of TCa (7.4%) and GCa (6.7%) in EG, respectively. The overall recurrent rate in EG is 7%, which is also statistically significantly lower than that (32%) in CG. The 3-year overall survival (OS) rate and 3-year disease-free survival (DFS) rate of EG is 100% and 93%, respectively. The 3-year OS and DFS rates of CG are 94 and 68%, respectively. Mild or medium fever and flu-like symptoms were more frequently observed in EG and were considered to be associated with application of rAd-p53. Post-tumorectomy wound surface injection of rAd-p53 combining with radiotherapy is a safe and effective regimen for the patients with TGa or GCa. © 2013 Nature America, Inc. All rights reserved.


Liu S.,Nankai University | Chen P.,301 Military General Hospital | Hu M.,301 Military General Hospital | Tao Y.,301 Military General Hospital | And 5 more authors.
Journal of Cancer Science and Therapy | Year: 2012

Objective: To evaluate benefits of Recombinant Adeno-viral Human p53 (rAd-p53) gene therapy combined with radiotherapy in prevention of oral cancer recurrence after a radical resection. Methods: A total of 215 patients with resectable Tongue Cancer (TCa) and 268 patients with resectable Gingival Carcinoma (GCa) satisfying the inclusion criteria and were randomly assigned to two groups: the Experiment Group (EG) and the Control Group (CG). The EG received multi-point injections of rAd-p53 into the wound surface at a dose of 1 × 10 12 Viral Particles (VP) after a radical resection. Both EG and CG were given radiotherapy at a total dose of 60 Gy three weeks after surgery. All these patients will be followed at least for 3 years. Results: Among these 483 cases, 107 patients (57 in EG and 50 in CG) finished 3-years follow-up. Two cases (2/27) of TCa and 2 (2/30) in GCa patients had a local recurrence in EG, but 8 (8/24) TCa and 8 (8/26) GCa patients in CG had a local recurrence. Both recurrent rates of TCa (33.3%) and GCa (30.8%) in CG are statistically significantly higher than that of TCa (7.4%) and GCa (6.7%) in EG, respectively. The overall recurrent rate in EG is 7.0%, which is also statistically significantly lower than that (32%) in CG. Overall 3-years survival (OS) rate of EG is 100% and the progress free survival (PFS) rate is 93.0% and the minimum PFS time is 29 months. The 3-years OS and PFS rates of CG are 94.0% and 68.0%, respectively. Except for self-limited fever, no other adverse reaction was found to be relative to rAd-p53. Conclusions: Post-tumorectomy wound surface injection of rAd-p53 combining with radiotherapy is safe, and may prevent local recurrence and increase both OS and PFS rate for the patients with TCa or GCa. © 2012 Liu S, et al.


Yu M.,301 Military General Hospital | Chen W.,301 Military General Hospital | Zhang J.,Military General Hospital
Anti-Cancer Drugs | Year: 2010

The objective of this study is to explore the safety, efficacy, and administration method of the recombinant adenovirus p53 gene (rAd-p53, or gendicine) in the treatment of pulmonary metastasis tumor from advanced hepatocellular carcinoma (HCC). Pulmonary metastasis tumors from HCC in 20 patients were treated by using transcatheter bronchial arterial gendicine infusion combined with transcatheter arterial embolization and intratumor injection of gendicine if the maximal diameter of a metastatic tumor is greater than or equal to 3?cm. Three patients received the combined therapy three times, seven received it twice, and ten received it once. Eighteen patients were followed for 2-12 months after treatment and two patients were lost to follow-up. Spiral computed tomography was performed during follow-up visits to monitor tumor progress. Lung metastasis tumor disappeared in four patients and the tumor size decreased in six patients, remained unchanged in five, and increased in three patients. Overall, the clinical symptoms were alleviated in 16 patients (88.9%) and were exacerbated in two patients. New metastatic lesions were found in eight patients. There were no serious adverse events except for self-limited fever (38°C-39.5°C), which was found in 16 patients. Transcatheter bronchial arterial gendicine infusion combined with transcatheter arterial embolization, with or without intratumor injection of gendicine, is a safe, effective therapy for the treatment of pulmonary metastasis tumor from HCC. Copyright © Lippincott Williams & Wilkins.

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