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Glaudemans A.W.J.M.,University of Groningen | Maccioni F.,University of Rome La Sapienza | Mansi L.,2nd University of Naples | Dierckx R.A.J.O.,University of Groningen | And 2 more authors.
Journal of Cellular Physiology | Year: 2010

Inflammatory bowel diseases are represented by ulcerative colitis and Crohn's disease, both consisting of a chronic, uncontrolled inflammation of the intestinal mucosa of any part of the gastrointestinal tract with patchy or continuous inflammation. Ileo-colonoscopy is considered the current gold standard imaging technique for the diagnosis. However, as the majority of patients need a long-term follow-up it would be ideal to rely on a non-invasive technique with good compliance. This review focuses on nuclear medicine imaging techniques in Crohn's disease. Different scintigraphic methods of imaging cells involved in the pathogenesis are described. The radiopharmaceuticals can be divided into non-specific radiopharmaceuticals for inflammation and specific radiopharmaceuticals that directly image lymphocytes involved in the process. This non-invasive molecular imaging approach can be useful also because it images the small bowel or other areas - where colonoscopy is not useful - and that it may play a role for constant follow-up, because relapses are frequent. Finally, an update on other imaging modalities, and particularly MRI, in the evaluation of Crohn's disease activity, is provided. Although MRI cannot directly detect inflammatory cells, it has shown a high sensitivity in detecting the macroscopic signs of inflammation at the level of the intestinal wall affected by Crohn's disease and Ulcerative colitis. The current diagnostic value of MRI in the detection of inflamed bowel segment and in the assessment of CD activity, as well the potentials MR spectroscopy, MR diffusion imaging and MR molecular imaging, is briefly discussed. © 2010 Wiley-Liss, Inc.


Morganti P.,2nd University of Naples | Morganti P.,Shenyang University | Morganti P.,Mavi Sud s.r.l.
Journal of Applied Cosmetology | Year: 2015

According to Europe 2020 strategy, a sustainable, more competitive, and greener economy is regarded as development that meets the today needs without compromising the needs of the future generations. The new green growth is to be based on a low carbon, climate resilient, and resource-efficient economy, minimizing waste and pollution and protecting-restoring the earth ecosystem. In addition a green economy can create new jobs trying to solve both the EU problem of youth unemployment and the preservation of natural resources by the use of waste material from animal and plant biomass. Young people, in fact, are the group most adaptable to the changes, easily accepting jobs in the new and unexplored areas of bionanotechnologies, by the use of industrial by-products representing ∼300 billion/year of unused available and precious raw materials. Thus, the green economy has been recognized as a potential source of employment and a contributor to economic recovery, representing both a challenge and an opportunity for the labour market and the environment preservation. MAVI as producer of Chitin Nanofibrils (CN), obtained from the crustacean waste by a green technology, has been involved in different EU research projects to produce innovative biocomposites for pharmaceutical and cosmetic use and/or food packaging. By the Biomimetic project (www.biomimetic-eu-project.eu/) innovative emulsions and non-woven beauty masks have been realized; by Chitofarma (www.mavicosmetics.it) advanced medications have been made by biodegradable non-woven tissues; by n-Chitopack (www.n-Chitopack.eu) different food packaging have been made completely biodegradable and compostable. It is to underline that all the projects, based on the production of green biocomposites, have been based on the use of crystal-CN and other natural polymers, all obtained from waste material by a low consume of energy and water, according to the EU, OECD, and UNEP guidelines. The origin of chitin and its crystallinity has determined, in fact, the structure, morphology and the particular properties of CN used as filler, as well as the other bio-based polymers have represented the matrix of the composites obtained into the university of Pisa. In conclusion the different green products resulting from the projects will be shown by this paper, focusing the discussion on the present necessity for a sustainable development. A green economy in fact, implies not only a right economic, social and environmental development but also a bettering of the quality of life, through education and training in line with labour market demands, and human knowledge. At this purpose it is to remember that a young-looking is psychologically connected with the necessity to show a healthy appearance also. Thus, a healthy and beauty body, as well as an increased and ameliorated education is one of the priorities of the EU 2020 strategy, along with labour productivity growth, lower unemployment, better insertion of young people in the labour market, increasing public participation in education, and lifelong learning. Recent EU studies reported, in fact, that by 2020 2.8 million jobs are expected to be created by the green economy.


Wolf R.,Hebrew University of Jerusalem | Wolf D.,Pediatric Outpatient Clinic | Ruocco E.,2nd University of Naples | Brunetti G.,2nd University of Naples | Ruocco V.,2nd University of Naples
Clinics in Dermatology | Year: 2011

The term "isotopic response" was coined by Wolf et al in 1995 to describe the occurrence of a new skin disorder at the site of another unrelated and already healed skin disease. When this term was found to be unsuitable for Medline searches because it generated hundreds of references that were linked with radioactive isotopes, it was changed to "Wolf's isotopic response" and eventually included as such in Stedman's Illustrated Dictionary of Dermatology Eponyms. Our search of the literature yielded 176 cases of Wolf's isotopic response. We describe this entity and present representative clinical examples. Some problems in the definition of Wolf's isotopic response are provided with special emphasis on its overlapping with the Koebner isomorphic response, a similar, but different, phenomenon. Also addressed are a number of issues associated with another term, "isotopic nonresponse," which had been introduced in analogy to the "isomorphic nonresponse" for describing the absence of an eruption at the site of another unrelated and already healed skin disease, or the sparing of the sites of another unrelated and already healed skin disease. In the spirit of the present issue, this contribution discusses only the clinical morphology and not the etiology, pathomechanism, or molecular biology of Wolf's isotopic response. © 2011 Elsevier Inc.


Serati M.,University of Insubria | Bogani G.,University of Insubria | Sorice P.,University of Insubria | Braga A.,University of Insubria | And 5 more authors.
European Urology | Year: 2014

Context Surgery represents the mainstay of treatment for pelvic organ prolapse (POP). Among different surgical procedures, abdominal sacrocolpopexy (SC) is the gold standard for apical or multicompartmental POP. Research has recently focused on the role of robot-assisted sacrocolpopexy (RASC). Objective To conduct a systematic review on the outcomes of RASC. Evidence acquisition PubMed, Scopus, and Web of Science databases as well as ClinicalTrials.gov were searched for English-language literature on RASC. A total of 509 articles were screened; 50 (10%) were selected, and 27 (5%) were included. Studies were evaluated per the Grading of Recommendations, Assessment, Development, and Evaluation system and the European Association of Urology guidelines. Evidence synthesis Overall, data on 1488 RASCs were collected from 27 studies, published from 2006 to 2013. Objective and subjective cures ranged from 84% to 100% and from 92% to 95%, respectively. Conversion rate to open surgery was <1% (range: 0-5%). Intraoperative, severe postoperative complications, and mesh erosion rates were 3% (range: 0-19%), 2% (range: 0-8%), and 2% (range: 0-8%), respectively. Surgical-related outcomes have improved with increased experience, with an estimated learning curve of about 10-20 procedures. Laparoscopic SC is less costly than RASC, although the latter has lower costs than abdominal SC. Conclusions RASC is a safe and feasible procedure for POP; it allows the execution of complex surgical steps via minimally invasive surgery without medium- and long-term anatomic detriments. Further prospective studies are needed to confirm these findings. Patient summary We looked at the outcomes of robotic sacrocolpopexy for prolapse. We found that the use of robotic technology is safe and effective for the treatment of prolapse in women. © 2014 European Association of Urology.


Ceriello A.,Hospital Clinic Barcelona | Novials A.,Hospital Clinic Barcelona | Canivell S.,Hospital Clinic Barcelona | La Sala L.,Hospital Clinic Barcelona | And 6 more authors.
Diabetes Care | Year: 2014

OBJECTIVE: To test the hypothesis that the simultaneous administration of GLP-1 and insulin may increase their vasodilatory, antiinflammatory, and antioxidant action in type 2 diabetes. RESEARCH DESIGN AND METHODS: In two groups of persons with type 2 diabetes, two sets of experiments were performed. The first group had two normoglycemic-normoinsulinemic clamps with or without GLP-1 and two normoglycemic-hyperinsulinemic clamps with or without GLP-1. The second group had two hyperglycemic-normoinsulinemic clamps and two hyperglycemic-hyperinsulinemic clamps with or without GLP-1. RESULTS: During the normoglycemic-hyperinsulinemic clamp, flow-mediated dilatation (FMD) increased, while soluble intercellular adhesionmolecule (sICAM-1), plasma 8-iso-prostaglandin F2α (8-iso-PGF2α), nitrotyrosine, and interleukin (IL)-6 decreased compared with normoglycemic-normoinsulinemic clamp. Similar results were obtained with the infusion ofGLP-1 during the normoglycemic-normoinsulinemic clamp. The combination of hyperinsulinemia and GLP-1 in normoglycemia was accompanied by a further FMD increase and sICAM-1, 8-iso-PGF2α, nitrotyrosine, and IL-6 decrease. During the hyperglycemic-normoinsulinemic clamp, FMD significantly decreased, while sICAM-1, 8-iso-PGF2α, nitrotyrosine, and IL-6 significantly increased. When hyperglycemia was accompanied by hyperinsulinemia or by the simultaneous infusion of GLP-1, these phenomena were attenuated. The simultaneous presence of hyperinsulinemia and GLP-1 had an increased beneficial effect. CONCLUSIONS: Our results show that the combination of insulin and GLP-1 is more effective than insulin or GLP-1 alone in improving endothelial dysfunction, infl ammation, and oxidative stress in type 2 diabetes. © 2014 by the American Diabetes Association.


Resmini G.,Treviglio Caravaggio Hospital | Tarantino U.,University of Rome Tor Vergata | Iolascon G.,2nd University of Naples
Aging Clinical and Experimental Research | Year: 2013

The major role of vitamin D in humans is to increase the absorption of calcium and phosphatase for the mineralization of the skeleton. The synthesis of vitamin D3 in the skin under influence of UV light decreases with aging due to insufficient sunlight exposure, and a decreased functional capacity of the skin. Deficiency in vitamin D causes secondary hyperparathyroidism, high bone turnover, bone loss, mineralization defects, proximal myopathy, falls and hip and other fractures. The goal of therapy of hypovitaminosis D is to restore normal serum and deposits of 25 (OH) D. The daily supplementation of vitamin D indicated is about 800-1,000 IU/day but may increase up to a maximum dose of 2,000 IU/day in conditions of severe vitamin D deficiency with a concomitant reduced or no sun exposure, reduced dietary intake and reduced calcium absorption. © 2013 Springer International Publishing Switzerland.


Resmini G.,Treviglio Caravaggio Hospital | Iolascon G.,2nd University of Naples
Aging Clinical and Experimental Research | Year: 2011

Parathyroid hormone (PTH) is secreted by the parathyroid glands and is an important regulator of blood calcium concentrations. Synthesis and secretion of PTH are stimulated by a decrease in blood calcium. PTH has three actions: 1) to increase the release of calcium from bone, 2) to reduce renal clearance of calcium, and 3) to stimulate the production of 1,25 (OH)2D 3. Human parathyroid hormone is a single chain polypeptide with 84 amino acids and a molecular weight of 9425 Da. The N-terminal region, 1-34, is biologically active and sufficient for regulation of mineral ion homeostasis (1). Recombinant teriparatide {human PTH(1-34) [hPTH (1-34)}}, currently the only bone-forming osteoporosis drug available for clinical use, increases bone turnover with a greater stimulation of formation than resorption (2). Bone turnover markers also rise during treatment with teriparatide (TPTD), with markers of bone formation rising early and rapidly, followed by rises in bone resorption markers. ©2011, Editrice Kurtis.


Cazzola M.,University of Rome Tor Vergata | Segreti A.,University of Rome Tor Vergata | Matera M.G.,2nd University of Naples
Current Opinion in Pulmonary Medicine | Year: 2010

Purpose of review: Because of the central role of bronchodilators in the treatment of asthma, in recent years there has been a renewed interest in the field and now once-daily bronchodilators are in development in an attempt to simplify their use. Recent findings: A variety of β2-agonists with long half-lives, also called ultra long-acting β2-agonists (ultra-LABAs; indacaterol, carmoterol, milveterol, GSK-642444, BI-1744-CL, LAS-100977, and PF-00610355) are currently under development with the hopes of achieving once-daily dosing. Between them, indacaterol, GSK-642444, and carmoterol are at a more advanced stage of development. Also several novel inhaled long-acting antimuscarinic agents are currently being developed, but their role in the treatment of asthma is limited. As combination therapy with an inhaled corticosteroid (ICS) and a LABA is considered the first-line approach for treating patients suffering from asthma, some novel once-daily combinations of LABAs and ICSs are under development. Summary: Bronchodilators are central in the symptomatic management of asthma. It is likely that the once-daily dosing of a bronchodilator would be a significant convenience and probably a compliance-enhancing advantage, leading to improved overall clinical outcomes in patients with asthma. In any case, as a LABA in combination with an ICS continues to be the most effective asthma treatment, once-daily combinations of ultra-LABAs and ICSs will be central in the treatment of asthmatic patients in the next years. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.


Mechanical cecorectal anastomosis after subtotal colectomy, in the treatment of slow transit constipation, probably represents the most attractive surgical alternative to total colectomy and ileorectal anastomosis. In fact the operation allows better results in terms of postoperative diarrhoea, fecal incontinence and postoperative adherential syndrome. Literature data have demonstrated the feasibility of the laparoscopic approach with tipically advantages of less invasive surgery respect of parietal integrity,less postoperative pain and ileus, fewer postoperative adhesions, a reduced hospitalitation and finally, a better cosmesis. The Authors report a case of mechanical end to end cecorectal anastomosis after laparo-assisted subtotal colectomy (by four trocars) preserving superior rectal and ilecolic vessels, for the treatment of slow transit constipation in a 20 years old male patient .The reported operative approach which links tipical laparoscopic advantages to a more "safety" and "accurate" extracorporeal mechanical anastomosis.


Ruocco E.,2nd University of Naples | Brunetti G.,2nd University of Naples | Del Vecchio M.,2nd University of Naples | Ruocco V.,2nd University of Naples
Journal of the European Academy of Dermatology and Venereology | Year: 2011

Exfoliative cytology for diagnostic purposes is rarely used in Dermatology despite the rapid and reliable results which this procedure can offer in many clinical conditions. This simple procedure may prove advantageous in a wide range of skin diseases, including genodermatoses (Hailey-Hailey disease), infections (mainly herpetic infections, molluscum contagiosum, leishmaniasis), immune disorders (early oral pemphigus) and tumours (basal and squamous cell carcinomas, Paget disease, erythroplasia of Queyrat, and others). The specific circumstances where cytological examination provides a very helpful and practical aid to confirmation or exclusion of a clinically suspected diagnosis are briefly reviewed. Cytological patterns, along with some technical hints on how to take and stain Tzanck smears correctly, are described in connection with the diseases considered. © 2010 European Academy of Dermatology and Venereology.

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