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Medicine, China

Zhang N.,2nd Affiliated Hospital | Yin Y.,Zhejiang University | Xu S.-J.,Zhejiang University | Wu Y.-P.,2nd Affiliated Hospital | Chen W.-S.,2nd Affiliated Hospital
Indian Journal of Medical Research | Year: 2012

Spinal cord injury (SCI) consists of a two-steps process involving a primary mechanical injury followed by an inflammatory process and apoptosis. Secondary insult is characterized by further destruction of neuronal and glial cells, and leads to expansion of the damage, so that the paralysis can extend to higher segments. With the identification of mechanisms that either promote or prevent neuronal inflammation and apoptosis come new approaches for preventing and treating neurodegenerative disorders. From a clinical perspective, this article discusses novel targets for the development of therapeutic agents that have the potential to protect the spinal cord from irreversible damage and promote functional recovery.

Zhang J.,2nd Affiliated Hospital | Wang Z.,2nd Affiliated Hospital | Lou H.,2nd Affiliated Hospital | Xu W.,China Jiliang University | And 2 more authors.
Gaodianya Jishu/High Voltage Engineering | Year: 2014

As one of the key components in MRI systems, radio-frequency (RF) coil is used for transmitting or receiving RF signals. In 3 T breast MRI, using dedicated breast RF coils could further improve the image quality. To obtain simple winding patterns for this dedicated coil while assuring the homogeneity of its RF magnetic field, we studied the effect of using penalty factors automatically chosen by L-curve method and manually selected on the winding patterns and the field homogeneity, and proposed an inverse design method for the 3 T breast RF that combines the target field method and the stream function method. Several conclusions can be drawn as follows: The winding patterns for 1×1, 2×1, 2×2, 4×1 array become more complex with increasing array number. Using penalty factor automatically selected with the L-curve method, we can obtain the most precise solution of magnetic field intensity's linear equations. The error of 1×1 arrays between real and ideal magnetic fields is over 40% when the penalty factor is chosen between 10-25 and 10-18. Meanwhile, the errors of 2×2 and 4×1 arrays are less than 10% when the penalty factor is automatically selected, but in this case the winding pattern gets too complex to be implemented in engineering applications. Manually selecting the penalty factor can make the winding pattern simple while keeping the error between real and ideal magnetic fields within 40%. Compared with the cylindrical RF coil which has the same radius and height, the hemispherical breast RF coil proposed in this paper has magnetic field with better homogeneity. It is concluded that when the penalty factor decreases, the winding pattern becomes more complex but the magnetic field gets more homogeneous. Conversely, when the penalty factor increases, the winding pattern becomes simpler but the magnetic field becomes less ideal. To balance the simplicity and the homogeneity of magnetic field, it is better to determine the penalty factor manually according to the L-curve. ©, 2014, Science Press. All right reserved.

Zhang Q.,2nd Affiliated Hospital | Xu M.,2nd Affiliated Hospital | Zhang X.,2nd Affiliated Hospital | Ren T.,Oregon Health And Science University | And 3 more authors.
Acta Oto-Laryngologica | Year: 2010

We here present a 32-month follow-up of a case of Lermoyez syndrome combined with Meniere's disease. The patient was a 49-year-old male, with a stabilized severe hearing loss in the left ear for about 15 years after Meniere's disease. He started to show typical symptoms of Lermoyez syndrome in the right ear about 32 months ago. Audiologic data were obtained and imaging examinations were performed 0, 9, 15, 28, and 32 months after the onset of the Lermoyez syndrome. Pure tone threshold data obtained 5 months before the onset are also reported. The results show that the hearing thresholds, mainly at low frequencies, elevated rapidly during the first months shortly after the onset of the disease and slowly in later months. The glycerol test resulted in a remarkable hearing improvement at the beginning of the disease, but showed no detectable improvements as the disease advanced. Electrocochleogram revealed a -SP/AP value with click stimulus 0.65 at the 9th month and >1.0 at the 28th month after the onset. Clinical manifestations of this patient fit well with a pathological endolymphatic hydrops. © 2010 Informa Healthcare.

Fan L.,Guangdong Provincial Hospital of Chinese Medicine | Li J.,2nd Affiliated Hospital | Ni Y.,2nd Affiliated Hospital | Wang Y.,2nd Affiliated Hospital
Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014 | Year: 2014

Objective: To evaluate the clinical efficacy of the treatment of non-organic insomnia due to deficiency of the heart and spleen treated by acupuncture with ear pricking. Methods: 64 inclusive patients were randomly divided into two groups with ratio 1:1, control group treated only by acupuncture, treatment group treated by acupuncture combined with ear pricking. The treatment period was 3 months. Results: 1. When comparing 1 month after and before the treatment, as well as 3 months after and 1 month after the treatment, the PSQI total score and TCM syndrome scale score of the two groups were decreased, showing statistically significant difference (P<0.05); 1 month or 3 months after the treatment, there were statistically significant difference (P<0.05) in the PSQI total score and TCM syndrome scale score between the two group; 2. When comparing 3 months after the treatment and before the treatment, the scores of PF, RP, GH, VT, SF, RE, BP and MH in SF-36 Scale of the two groups were increased, showing statistically significant difference (P<0.05); 3 months after the treatment, the scores of RP, VT and SF of the treatment group were significantly higher than those of the control group, showing statistically significant difference (P<0.05); 3. 3 months after the treatment, the curative effect of the treatment group was better than that of the control group, showing statistically significant difference (P<0.05); as to effective rate, the treatment group was better than the control group, showing statistically significant difference (P<0.05). Conclusion: Both acupuncture with ear pricking and only acupuncture show therapeutic effects in treating non-organic insomnia due to deficiency of both the heart and spleen, and the former is better than the latter in improving quality of life and clinical effect. © 2014 IEEE.

Wu M.,2nd Affiliated Hospital | Zhang S.,2nd Affiliated Hospital | Dong A.,2nd Affiliated Hospital | He Z.,2nd Affiliated Hospital | And 2 more authors.
Annals of Thoracic Surgery | Year: 2010

Background: This study aimed to analyze the long-term results of mitral valve replacement and concomitant Cox-Maze III procedure (CMP) in treating rheumatic heart valve disease and associated permanent atrial fibrillation. Outcomes of CMP using a pure "cut-and-sew" method were assessed. Methods: Between 1995 and 2004, 60 patients received mechanical mitral (or mitral plus aortic) valve replacement and concomitant CMP. Among them, 22 underwent classic CMP that included five localized cryoablations, and 38 received a CMP without using cryoablations. All patients received periodic follow-up and oral anticoagulation therapy. Results: The demographic features of both groups of patients were comparable. A total of 65 mechanic valves were implanted. Operative data and in-hospital outcomes were insignificant except that the immediate sinus conversion rate was higher in the pure cut-and-sew group. At last follow-up, sinus rhythm was 81.1% in the pure cut-and-sew group (median, 112 months) and 72.7% in the classic CMP group (median, 113 months; p = 0.4541). Actuarial freedom from atrial fibrillation was also similar (5 years, 83.8% versus 76.8%; 10 years, 79.1% versus 70.4%; p = 0.6039). In both groups, the late results of left atrium size were significantly reduced, while the proportion of long-term tricuspid regurgitation was still remarkable. Conclusions: Mitral valve replacement and concomitant CMP is effective in treating rheumatic valve disease and permanent atrial fibrillation with satisfactory results. A complete cut-and-sew method is technically practicable, and is as effective as the classic CMP in the long term. © 2010 The Society of Thoracic Surgeons.

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