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BOULDER, CO, United States

Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 80.45K | Year: 2006

DESCRIPTION (provided by applicant): In this proposal we respond to the PHS 2005-2 Omnibus Solicitation's call for the development of diagnostic tools for "non-invasive methodologies for measuring airways inflammation in asthma." We propose to develop, test and evaluate a low cost, portable analyzer for the measurement of nitric oxide (NO) in human breath as an indicator of airway inflammation, especially for the diagnosis and treatment of asthma. A method for NO measurement in exhaled breath recently was approved by the U.S. Food and Drug Administration and its equivalent in the European Union for the purpose of diagnosing, monitoring and treating patients with asthma and other airway diseases. The instrumental approach (NIOX(r) of Aerocrine AB) makes use of the highly sensitive technique of NO + O3 chemiluminescence, but that method is too complicated and expensive for use in the home. In preliminary results, we have demonstrated the use of a much simpler technique that uses the NO + O3 reaction in a different way. Instead of measuring chemiluminescence, the loss of O3 is measured by UV absorption at 254 nm using a low pressure mercury lamp. This approach, which recently has been successfully marketed in for atmospheric measurements, gives adequate precision (q2 ppbv) and accuracy (q2%) for breath analysis. In addition to being small, light weight and having low power requirements, this new approach eliminates the need for gas standards contained in high pressure gas cylinders. The simplified "stopped flow" design proposed here eliminates the possibility of interference from major components in breath such as water vapor and carbon dioxide. Because of their slow reaction, VOCs such as isoprene also are not expected to interfere. In Phase I we will develop and test a prototype instrument that will be used in a clinical intercomparison with the FDA-approved NIOX apparatus for establishment of equivalency during Phase II. RELEVANCE TO PUBLIC HEALTH The objective of this work is to develop a low cost, accurate and reliable instrument for use in the home that can be used for optimizing the use of therapeutic drugs in the management of asthma.

Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 99.98K | Year: 2006

DESCRIPTION (provided by applicant): Project Summary/Abstract: Iodide deficiency disorders (IDDs) have been identified by the World Health Organization as a serious global health problem affecting 740 million people in 130 countries. Iodine deficiency is t he most common cause of preventable brain damage, with nearly 50 million people suffering some degree of IDD-related brain damage. IDD is preventable and treatable by iodization of table salt. Identification of individuals suffering from IDD and population s at risk requires the development of an instrument capable of measuring iodine in urine and table salt. We propose to develop a small, lightweight, inexpensive instrument to achieve quantification of iodine. The Rapid Iodine Analyzer (RIA) will allow meas urement of iodine present as either iodide or iodate. The instrument will be based on a novel and proprietary detection method described in the text of the proposal. It will be highly automated and will require very little sample preparation. The portable instrument is expected to have a limit of detection of ~1 ppb and to be free of interferences. Thus, the sensitivity will be adequate to diagnose patients as having moderate (20-49 ppb) or severe iodine deficiency (lt 20 ppb), as well as those having norma l (100-199 ppb) or excess iodine (gt300 ppb) in their urine. Because of its low cost (~ 2,000 retail), portability (lt 5 lb), and low power requirements (~2 watt), the iodine instrument will be highly useful for assessing iodine deficiency in populations i n remote locations around the globe and for testing for the presence of iodine additives to salts dispensed in those regions. Project Narrative(Relevance): A high sensitive (.~ 1ppb) portable instrument will be developed for the measurement of iodide and i odate in urine and table salt. The Rapid Iodine Analyzer will be highly useful in addressing the problem of iodine deficiency disorder currently affecting 740 million people in 130 countries.

Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 149.69K | Year: 2014

DESCRIPTION (provided by applicant): We propose to make air pollution personal by enabling K-12 students to act as citizen scientists using sophisticated, mobile air pollution monitors to measure their individual exposures to black carbon, a primary pollutant, and ozone, a secondary pollutant. Through their experiments and specially designed curricula, students will learn when and where they and others are exposed to these damaging air pollutants and how that exposure can affect their health. Ozone and black carbon are two of the most damaging air pollutants to human health, and it has been shown that both are asthma triggers and can lead to other health problems, including heart disease and even premature death. Heightened awareness of the way air quality impacts health is vital, and nothing is more impactful than understanding exposure at a personal level. Through our nonprofit partner the GO3 Project, ~50 schools will be loaned a 2B Tech Personal Ozone Monitor (POM) and microAeth personal black carbon

Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase II | Award Amount: 499.73K | Year: 2015

DESCRIPTION provided by applicant Personal Exposure Monitoring of Air Pollutants as an Educational Tool in the GO Treks project launched by the Phase I grant students at schools throughout the U S used personal monitors to measure the air pollutants black carbon and ozone along treks of their own design The treks were uploaded to blogs in the GO website where they were displayed on Google Earth and where students teachers GO staff and air quality scientists discussed the results The students learned about the sources transformations and sinks of air pollutants by acting as citizen scientists forming and testing their own hypotheses using real scientific instruments Highlights include comparisons of rural vs urban exposures discovery of increased pollution levels during pick up drop off traffic at schools comparisons of pollutant levels along busy and residential streets analysis of exposures during commutes to school a trek at a hydraulic fracturing site treks from urban areas into the mountains and investigation of emissions from different types of sources such as lawnmowers and buses One school explored an area that is known to have an underground coal mine fire and even launched the ozone monitor on a balloon to km ft where ozone in the stratosphere was measured We propose to improve upon and expand GO Treks in the Phase II project by implementing a quality assurance QA program for GO Treks data developing a universal Personal Air Monitoring Module PAMM that will allow any air quality sensor to upload data in real time to GO Treks via a smart phone app expanding the suite of miniaturized instruments available to GO Treks to include CO and Equivalent PM in addition to O and black carbon and revising the GO online curriculum to be smaller andquot bite sizedandquot modules each of which can be completing in an hour or less and awarding digital badges for completion of each module Individuals who earn all GO Air Quality digital badges including those awarded for participation in a trek and for achieving a prescribed level of activit on the GO network will be awarded a Mozilla Open Badge that can be included in their digital resume The commercialization plan expands GO Treks to include citizen monitoring by environmental advocates and local government agencies in addition to schools and proposes rental of instruments at a fee of only $ week A business model is proposed that provides exponential growth of the project by continuous reinvestment of all but of profit in new inventory Model results using reasonable assumptions show that in four years GO Treks could be grown to annual rentals of $ M with servicing of organizations from an inventory of instruments PUBLIC HEALTH RELEVANCE The GO Treks project allows citizen scientists including students hobbyists environmental advocates and local government officials to measure air pollutants such as ozone black carbon particulate matter PM and CO along treks in their local communities A Personal Air Monitoring Module PAMM will allow measurements made using any air quality sensor to be uploaded via a cell phone app for display on Google Earth within a public blog for data sharing and public discussion

2B Technologies, Inc. | Date: 2015-06-26

The present invention provides a means of measuring the concentration of ozone dissolved in water or another solvent. Small, discrete samples are sparged with air or another unreactive gas for a short period of time to measure a profile of ozone vs time in the sparge gas. The total amount of ozone in the original sample is obtained by integrating under the ozone vs time profile. A correction may be made for ozone remaining in the sample after a finite sparge time by integrating under the profile tail using a decay constant obtained from the measured ozone vs time profile. The method differs from previous methods based on sparging of the sample in that a Henrys Law equilibrium or constant ratio of ozone present in the gas and liquid phases is not assumed and the flow rates of sample and sparge gas are not continuous. Instead, discrete samples are analyzed by nearly complete sparging. The new method is applicable to dirty (impure) water because the ozone is measured in the absence of UV-absorbing and scattering impurities that may be present in the sample. The method applies to high purity water as well.

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