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Burger M.,American Museum of Natural History | Harvey M.S.,Western Australian Museum | Stevens N.,280 North
Journal of Arachnology | Year: 2010

The first blind Australian species of Tetrablemmidae and only the fourth in the world, Tetrablemma alaus, new species, is described from subterranean habitats in northwestern Australia. The total loss of eyes is correlated with its subterranean existence and is complemented by other troglomorphies including slightly elongated appendages and pale coloration. © 2010 The American Arachnological Society.

Martin J.M.,Toowoomba Cancer Research Center | Martin J.M.,280 North | Berthold D.R.,University of Lausanne
Drugs | Year: 2011

Locally advanced prostate cancer (LAPC) is a heterogeneous entity usually embracing T3-4 andor pelvic lymph-node-positive disease in the absence of established metastases. Outcomes for LAPC with single therapies have traditionally been poor, leading to the investigation of adjuvant therapies. Prostate cancer is a hormonally sensitive tumour, which usually responds to pharmacological manipulation of the androgen receptor or its testosterone-related ligands. As such, androgen deprivation therapy (ADT) has become an important adjuvant strategy for the treatment of LAPC, particularly for patients managed primarily with radiotherapy. Such results have generally not been replicated in surgical patients. With increased use of ADT has come improved awareness of the numerous toxicities associated with long-term use of these agents, as well as the development of strategies for minimizing ADT exposure and actively managing adverse effects. Several trials are exploring agents to enhance radiation cell sensitivity as well as the application of adjuvant docetaxel, an agent with proven efficacy in the metastatic, castrate-resistant setting. The recent work showing activity of cabazitaxel, sipuleucel-T and abiraterone for castrate-resistant disease in the post-docetaxel setting will see these agents investigated in conjunction with definitive surgery and radiotherapy. © 2011 Adis Data Information BV. All rights reserved.

Donnelly C.,Queens University | Brenchley C.,Ontario Society of Occupational Therapists | Crawford C.,280 North | Letts L.,McMaster University
BMC Family Practice | Year: 2013

Background: For over two decades occupational therapists have been encouraged to enhance their roles within primary care and focus on health promotion and prevention activities. While there is a clear fit between occupational therapy and primary care, there have been few practice examples, despite a growing body of evidence to support the role. In 2010, the province of Ontario, Canada provided funding to include occupational therapists as members of Family Health Teams, an interprofessional model of primary care. The integration of occupational therapists into this model of primary care is one of the first large scale initiatives of its kind in North America. The objective of the study was to examine how occupational therapy services are being integrated into primary care teams and understand the structures supporting the integration. Methods. A multiple case study design was used to provide an in-depth description of the integration of occupational therapy. Four Family Health Teams with occupational therapists as part of the team were identified. Data collection included in-depth interviews, document analyses, and questionnaires. Results: Each Family Health Team had a unique organizational structure that contributed to the integration of occupational therapy. Communication, trust and understanding of occupational therapy were key elements in the integration of occupational therapy into Family Health Teams, and were supported by a number of strategies including co-location, electronic medical records and team meetings. An understanding of occupational therapy was critical for integration into the team and physicians were less likely to understand the occupational therapy role than other health providers. Conclusion: With an increased emphasis on interprofessional primary care, new professions will be integrated into primary healthcare teams. The study found that explicit strategies and structures are required to facilitate the integration of a new professional group. An understanding of professional roles, trust and communication are foundations for interprofessional collaborative practice. © 2013 Donnelly et al.; licensee BioMed Central Ltd.

News Article | March 4, 2009
Site: www.techcrunch.com

Back when the iPhone first launched and the App Store was still a twinkle in Apple’s eye, the only way to get your goods onto the platform was to develop them as an iPhone-optimized web page – otherwise known as an iPhone Web App. Unable to make use of much of iPhone’s functionality (like the GPS, camera, etc.), Web Apps were quickly considered the inferior option when Apple unshackled the iPhone SDK, opening the doors for the standalone Objective-C apps which have since flooded through the App Store. It was great news for Objective-C developers and consumers looking for rich applications – but not so much for those who’d grown accustomed to developing for the web. At the recent Future of Web Apps conference in Miami, Y-Combinator-backed 280 North announced Atlas, a drag-and-drop visual editor for building desktop web applications with Cappuccino, 280 North’s Javascript-based framework. Near the tail end of the presentation, 280 North co-founder Francisco Tolmasky gave the audience a sneak peek of one of Atlas’ best features: iPhone support. The real trick? Atlas can wrap up iPhone Web Apps like native applications, granting them access to a significant portion of the iPhone API and allowing them to be sold through the App Store. This lowers the barrier of entry for iPhone development substantially, allowing those with Javascript knowledge to create fully functional applications on the platform without requiring them to learn a whole new language. The same limitations that apply to Javascript apply here, presumably – in other words, don’t expect to be throwing down ultra-rich OpenGL-based 3D games, but mid-range apps (such as Twitter clients, RSS readers, etc.) should be completely doable. How the API-related stuff works is still a bit of a mystery. 280 North is keeping mum on their methods for the time being – not only for the sake of maximum impact when Atlas launches in the coming months, but also because they’re still determining which of a handful of approaches will work best. I’d assumed that Atlas compiled the user’s code within a wrapper which served as a middle man, passing API calls to the iPhone and returning the results, but a quick chat with Tolmasky indicated that this wasn’t necessarily the case. If it works as demonstrated, it’s a wonderful idea. We’ll have to keep an eye on this one.

Hopkins A.L.,280 North | Clarke J.,280 North
Journal of Small Animal Practice | Year: 2010

A four-year-old neutered male bichon frise was presented for the evaluation of chronic, progressive yet episodic neurological dysfunction that was predominantly cerebellar in nature. Diagnostic testing including haematology, serum chemistry, magnetic resonance imaging, cerebrospinal fluid analysis and urine organic acid screening was normal. Trial therapies with phenobarbital, prednisone and acetazolamide were unsuccessful. Treatment with 4-aminopyridine led to complete resolution of the signs. © 2010 British Small Animal Veterinary Association.

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