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Zhangjiakou, China

Huang Y.,251 Hospital of PLA
International Journal of Clinical and Experimental Pathology

Basal cell adenoma (BCA) is a specific entity that lacks the myxochondroid stromal component of a pleomorphic adenoma. There are six histopathological types of BCA: solid, tubular, trabecular, membranous, cribriform, and myoepithelial-derived stroma rich. Myoepithelial-derived stroma rich variant is so rare, especially with cellular atypia. Herin we describe a rare case of BCA arising in the parotid on a 25-year-old man. A well-demarcated nodule arising in the parotid that was composed of basaloid cells, forming small duct-like or tubular structures containing basement membrane-like material, as well as highly cellular elongated cells with hyperchromatic, enlarged, pleomorphic, and bizarre nuclei. Immunohistochemically, S100 protein and p63 highlighted the basal aspect of the peripheral epithelial cells and peripheral spindle and bizarre cells, while CK7 expressed on the luminal cells. We made a diagnosis of "basal cell adenoma, myoepithelial-derived stroma rich variant, with bizarre myoepithelial proliferation". The differential diagnosis includes cellular pleomorphic adenoma, basal cell adenocarcinoma, and carcinoma ex pleomorphic adenoma. After follow-up for 3 years, there was no evidence of recurrence. Further pathological characteristics of this disease are discussed. Source

Wang Y.,Tangshan Gongren Hospital | Han X.-C.,Hebei North University | Zheng L.-Q.,251 Hospital of PLA | Miao W.-L.,Hebei North University
International Journal of Clinical and Experimental Pathology

Xanthogranulomatous cystitis is a rare, benign chronic inflammatory disorder with unclear etiology. Since its similar features to bladder neoplasm, it is extremely easy to be mistaken for malignant tumor. We herein reported a case of xanthogranulomatous cystitis in a 54-year-old male who presented with low abdominal pain and painless, total macrohematuria. Microscopy showed proliferation of large foam histiocytes which expressed CD68 and vimentin. Ki-67 showed a lower proliferation index (< 10%). Histopathology and immunohistochemical findings confirmed the diagnosis. This case highlighted the significance of recognizing this unusual lesion and differentiating it from its histological mimics by immunohistochemical staining. Source

Yin Y.-H.,Hebei North University | Wang H.-P.,Hebei North University | Yin S.-J.,251 Hospital of PLA | Liu H.-Q.,251 Hospital of PLA
Journal of Shanghai Jiaotong University (Medical Science)

Objective: To investigate the microanatomic and surgical exposure of supraorbital extradural approach to cavernous sinus under endoscope, so as to provide the microanatomic basis for clinical neurosurgery. Methods: Twenty fresh cadaver heads were studied using 4 mm 0° and 30° endoscopes to develop a surgical approach and identify surgical landmarks. Results: The endoscopic supraobital extradural approach could be divided into 3 stages: entry into the extradural anterior cranial fossa, exposure of the middle cranial fossa and periorbita, and exposure of the superior and lateral cavernous sinus. This approach could expose superb views of the cavernous sinus microanatomy especially through the Dolence triangle, Parkinson triangle and Mullan triangle. Conclusion: Endoscopic supraobital extradural approach offers excellent microanatomy of the cavernous sinus with minimal invasiveness, which is worthy of introduction. Source

Huang Y.,251 Hospital of PLA | Han X.-C.,Hebei North University | Lv G.-S.,251 Hospital of PLA
International Journal of Clinical and Experimental Pathology

Hemangioblastoma is a rare neoplasm occurred in soft tissue. Herein, we present an intriguing case of sporadic hemangioblastoma in the retroperitoneum occurring in a 59-year-old male. The tumor was characterized by an alternation of cellular and paucicellular areas surrounded by a thick fibrous capsule. The stromal cells showed a pale cytoplasm exhibiting occasional lipid droplets and hyperchromatic, irregularly nuclei. CD56, NSE, a-inhibin and S100 were positive in tumor cells. This is the third reported case of a hemangioblastoma in the retroperitoneum. Based on clinical examination, computed tomography imaging, surgical operation, and histopathologic studies, a definitive diagnosis was made. Further characteristic images and pathology of this disease are discussed. Source

Wu P.,Hebei North University | Lu G.-S.,251 Hospital of PLA | Han F.,251 Hospital of PLA | Xu K.-N.,251 Hospital of PLA
Journal of Shanghai Jiaotong University (Medical Science)

Objective: To investigate the efficacy of diffusion tensor tractography (DTT) in study of changes of cerebral white matter fiber after cerebral blast injury. Methods: Cerebral blast was conducted in 30 rabbits, and routine MRI and diffusion tensor imaging (DTI) were performed after injury. DTI was adjusted with Tensor software of Functool2, and cerebral white matter fiber of region of interest (ROI) was reconstructed on the basis of fractional anisotropy images. The cerebral histopathological changes were observed, and contrast analysis was carried out with findings from DTT. Results: After blast, 17 rabbits died, and the other 13 survived, among which 2 survived for more than 72 h. There were 4 types of cerebral white matter abnormality, which were color abnormality of ornamental code (n=2), deficiency/breakage+displacement (n=8), rarity+deficiency/breakage (n=6) and color abnormality of ornamental code+deficiency/breakage+displacement (n=14). Pathological examination indicated there was capillary break, capillary endothelial injury and hemorrhage, nerve cell and colloid cell degeneration and necrosis, nerve myelin sheath loss and formation of axon bulb. Conclusion: DTT may clearly and directly illustrate the injury of cerebral white matter fiber, especially for the small abnormal cerebral white matter fiber, and more complicated change of cerebral white matter fiber may lead to shorter duration of survival. Source

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