Sun Y.,General Hospital of Shenyang Military Command |
Xu K.,General Hospital of Shenyang Military Command |
Jiang T.-M.,College of Logistics |
Yang L.-X.,Kunming General Hospital of Chengdu Military Command |
And 15 more authors.
Medical Journal of Chinese People's Liberation Army | Year: 2016
Objective To explore the correlation between the degree of target vessel occlusion and in-hospital mortality in patients with acute ST-elevated myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). Methods To retrospectively analyze the data collected from the Management System of Cardiovascular Interventional Treatment in Military Hospitals. A total of 8170 patients with STEMI and PCI were enrolled, and the endpoint of present study was in-hospital mortality. The degree of target vessel occlusion were stratified to determine the effects of occlusion degree on in-hospital mortality. Results According to the degree of target vessel occlusion, the enrolled patients were divided into 2 groups: 75%-99% occlusion group and 100% occlusion group. The in-hospital mortality in the 2 groups were 2.2% and 3.0%, respectively (P=0.077). The patients were then further divided into 3 groups according to the symptom-onset-to-balloon time <3h, between 3h and 6h, and ≥6h. The in-hospital mortality in duration <3h group were 2.5% and 3.3%, respectively (P=0.436); duration between 3h and 6h group were 2.0% and 2.9%, respectively (P=0.147); and duration ≥6h group were 2.4% and 2.8%, respectively (P=0.430). Conclusion The in-hospital mortality in STEMI patients may be no relation with the degree of target vessel occlusion. © 2016, People’s Military Medical Press. All rights reserved.
Chen X.-Z.,The Second Peoples Hospital Of Yunnan Province |
Fang Y.,Kunming Medical University |
Shi Y.-H.,Shanxi Tumor Hospital |
Li L.-Y.,211 Hospital of PLA |
And 2 more authors.
Mitochondrial DNA | Year: 2014
To characterize the somatic mutation spectrum of mitochondrial DNA at D310 in Chinese lung cancer patients and evaluate its potential significance in Chinese lung cancer diagnosis, in this study, 237 samples, including lung tumor, adjacent normal tissue and blood samples of 79 lung cancer patients were analyzed. By comparing sequences of D310 between lung cancer tissues, adjacent normal tissue and blood samples, the somatic mutations at D310 were detected in 17.72% (14/79) of Chinese lung cancer patients; this implied that somatic mutations at D310 could be served as valuable biomarker for diagnostic of Chinese lung cancer. Further analyses indicated that deletion and heterogeneity were the predominant characters for somatic mutations detected at D310 of Chinese lung cancer patients. © 2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted
PubMed | The Second Peoples Hospital of Yunnan Province, 211 Hospital of PLA, Kunming Medical University and Shanxi Tumor Hospital
Type: Journal Article | Journal: Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis | Year: 2015
To characterize the somatic mutation spectrum of mitochondrial DNA at D310 in Chinese lung cancer patients and evaluate its potential significance in Chinese lung cancer diagnosis, in this study, 237 samples, including lung tumor, adjacent normal tissue and blood samples of 79 lung cancer patients were analyzed. By comparing sequences of D310 between lung cancer tissues, adjacent normal tissue and blood samples, the somatic mutations at D310 were detected in 17.72% (14/79) of Chinese lung cancer patients; this implied that somatic mutations at D310 could be served as valuable biomarker for diagnostic of Chinese lung cancer. Further analyses indicated that deletion and heterogeneity were the predominant characters for somatic mutations detected at D310 of Chinese lung cancer patients.
Li P.,General Hospital of Shenyang Military Command |
Liang L.-L.,General Hospital of Shenyang Military Command |
Zhang S.-W.,202 Hospital of PLA |
An L.,210 Hospital of PLA |
And 9 more authors.
Medical Journal of Chinese People's Liberation Army | Year: 2014
Objective: To investigate the integrated control levels of hemoglobin A1c(HbA1c), systolic and diastolic blood pressure (BP), low-density lipoprotein cholesterol (LDL-C) in retired army cadres suffering from type 2 diabetes (T2DM) in northeast China.Methods: Four hundred and seventy-seven retired army cadres (aged ≥50 years) with T2DM were interviewed using questionnaire. The subjects were assigned into two groups according to the presence (n=350) or without (n=127) cardiovascular disease (CVD), and then the control levels of HbA1c, fast blood glucose (FBG), 2-hour postprandial blood glucose (2hPG), BP, blood cholesterol (TC), triglycide (TG), high-density lipoprotein cholesterol (HDL-C) and LDL-C were compared between the two groups.Results: The overall successful rate of control of HbA1c(<7%) was 65.8%. The overall successful rate of controling HbA1cin diabetic patients without CVD was significantly higher than in those with CVD (74.8% vs 56.9%, χ2=13.857, P<0.05). The overall successful rate for controling LDL-C in enrolled subjects (<2.6mmol/L) was 47.8%. The overall successful rate for controling LDL-C in patients without CVD (<2.6mmol/L) was significantly higher than in those with CVD (<1.8mmol/L) (47.2% vs 23.9%, χ2=6.77, P<0.05). In 85.5% of patients the target of controling blood pressure (<140/80mmHg) was achieved. The successful rates were almost identical between the with- and without-CVD groups (85.1% vs 86.4%, χ2=0155, P>0.05). The comprehensive attainment rate for controling HbA1c, BP and LDL-C among all the subjects was 23.5%, and no significant difference was found between with- and without-CVD subjects (22.9% vs 25.1%, χ2=0.284, P>0.05).Conclusions: Under the military health care management system, the unique and comprehensive successful rate for controling HbA1c, BP and LDL-C was higher among retired army cadres in northeast China as compared with that in non-military Chinese populations, and it is close to, even higher than the reported levels abroad. The successful rate shows no difference between with- or without-CVD subjects. © 2014, People's Military Medical Press. All rights reserved.
Li Y.,Harbin Medical University |
Gu P.-F.,Shenyang Military General Hospital |
Shang Y.,463 Hospital of PLA |
Li Y.-C.,211 Hospital of PLA
Chinese Journal of New Drugs | Year: 2011
Objective: To evaluate the analgesic effect of dexmedetomidine combined with propofol in artificial abortion surgery, and the role in reducing propofol dose. Methods: Eighty ASA I patients were randomly divided into 2 groups. They were treated either with intravenous dexmedetomidine 0.5 μg · kg -1 followed by propofol injection, or with propofol alone. Hamilton anxiety scale (HAMA) was used to estimate anxiety condition during the surgery. Results: The motor activity, during the surgery post-surgery uterine contraction pain, additional dose and total dose of propofol, local injection pain and shiver rate, and HAMA score were significantly less in combination group than in propofol group (P < 0.05). Conclusion: Dexmedetomidine combined with propofol can significantly relieve patients' anxiety, reduce total propofol dose, potentiate analgesic effect and relieve post-surgery pain with less side effects.
Zheng D.-M.,General Hospital of PLA |
Li S.-H.,General Hospital of PLA |
Wang J.,211 Hospital of PLA |
Li C.,211 Hospital of PLA
Medical Journal of Chinese People's Liberation Army | Year: 2013
Objective To observe the effect of hypertensive disorders during pregnancy (HDP) on neonatal outcomes and umbilical artery flow. Methods A prospective cohort study method was employed, and 60 pregnant women met the HDP diagnostic criteria (HDP group, aged 31.2±6.0 years, gestation time 251.0±9.0d, hospitalized from Sep. 2011 to May. 2012, and delivered live-born infants) and 63 pregnant women with normal blood pressure and without medical or surgical ailments (control group, aged 30.2±2.8 years, gestation time 251.9±7.7d, hospitalized in the the same period, and had live birth) were involved in present study. The indexes of umbilical artery blood flow were measured, the adverse neonatal outcomes (neonatal asphyxia, low birth weight babies and premature labor) were recorded, and the correlation was analyzed between the adverse neonatal outcomes and the indexes of umbilical artery blood flow. Results The incidence of adverse neonatal outcomes (neonatal asphyxia, low birth weight newborns and premature labor) was higher in HDP group (58.3%, 45.0% and 53.3%, respectively) than in control group (6.3%, 3.2% and 3.2%, respectively, P<0.05). The results of umbilical artery blood flow indexes, including pulsatility index (PI), resistance index (RI) and systolic/diastolic ratio (S/D) in HDP group (0.897±0.176, 0.588±0.701 and 2.655±0.346, respectively) were significantly higher than in control group (0.741±0.123, 0.525±0.650 and 2.120±0.364, respectively, P<0.05). The indexes of umbilical artery blood flow (PI, RI and S/D) in newborns with adverse outcomes were significantly higher than in those newborn without adverse outcomes. Multivariate logistic regression revealed a positive correlation between RI and adverse neonatal outcomes. Conclusions The indexes of umbilical artery blood flow appear to be abnormal in pregnant women with HDP, and adverse neonatal conditions (neonatal asphyxia, low birth weight newborns and premature labor) are prone to occur in their newborns. The RI of umbilical artery may be related to the adverse neonatal outcomes.
Chen X.Z.,The Second Peoples Hospital Of Yunnan Province |
Fang Y.,Kunming Medical University |
Shi Y.H.,Shanxi Tumor Hospital |
Cui J.H.,Chinese People's Liberation Army |
And 3 more authors.
Genetics and Molecular Research | Year: 2015
The mitochondrion is a crucial intracellular organelle responsible for regulating cellular energy metabolism, producing free radicals, initiating and executing the apoptotic pathways. Previous studies have shown that somatic mutations in mitochondrial DNA are associated with various tumors, which may be involved during carcinogenesis and tumor progression. To examine the mutation pattern in cancer, 625 reported somatic mutations in the mitochondrial DNA genome were analyzed. We found that, except for deletions and insertions, most somatic mutations were point mutations, accounting for 89.44% of somatic mutations. Transition was the predominant form of somatic mutation in the entire mitochondrial DNA genome, accounting for 87.12% of point mutations, most of which were homoplastic. Frequency statistics analysis of point mutations indicated that, except for 3 tRNA genes, the mutations were distributed on all resting genes and in the D-loop region, with the latter showing the highest frequency of somatic mutation (19.34%), followed by the tRNA leucine 2 gene and non-coding regions between base pairs 5892 and 5903, while 13 coding-region genes and 2 rRNA genes showed a relatively lower frequency of somatic point mutations. Nonsynonymous mutations and terminal amino acid changes were the primary point somatic mutations detected from 13 coding-region genes, which may cause mitochondrial dysfunction in cancer cells. We found that the somatic mutations may affect the mitochondrial DNA genome; the non-coding region should be examined to identify somatic mutations as potential diagnostic biomarkers for early detection of cancer. © FUNPEC-RP.
Wang Z.-L.,211 Hospital of PLA |
Sun P.,211 Hospital of PLA |
Zhng W.-J.,211 Hospital of PLA |
Li Y.,211 Hospital of PLA |
And 7 more authors.
Medical Journal of Chinese People's Liberation Army | Year: 2015
Objective To explore the clinical efficacy of posterior atlantoaxial pedicle screw fixation for traumatic atlantoaxial instability. Methods From September 2009 to March 2013, 17 patients with atlantoaxial instability received posterior atlantoaxial pedicle screw fixation. There were 12 males and 5 females, with a mean age of 42 years old (ranged from 19 to 63 years old). Transpedicle screw fixation was employed in 8 patients with atlantoaxial fracture and dislocation, in 2 with traumatic disruption of transverse atlantal ligament, and in 7 with odontoid fracture. The Japanese Orthopaedic Asso ciation (JOA) score before operation was from 5 to 14, with a mean of 11.2. Preoperative CT, MRI and radiographs, as well as intraoperative screw placement and bone graft were administered in all the patients. Results In all the patients, complete reduction was achieved without injury to the vertebral artery, spinal cord or never root, and they started to be ambulatory on the first day after the operation. The patients were followed up for 6-36 months (mean 21 months), and clinical symptoms were seen to be improved significantly. Imaging reexamination 6 months after the surgery showed satisfactory healing of implanted bone and position of all the screws without loosening of the implant. The mean JOA scores was 15.5(11.0-17.0) twelve months after the operation. Conclusion Atlantoaxial pedicle screw fixation for traumatic atlantoaxial instability is safe and reliable with a favorable clinical result. © 2015 People's Military Medical Press. All rights reserved.