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Xiang Y.,210th Hospital of PLA
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban | Year: 2010

To investigate the effect of post-remission therapy mainly with Compound Huangdai Tablet (CHDT) on long-term survival of patients with acute promyelocytic leukemia (APL). One hundred and twelve APL patients were treated after remission mainly with CHDT administered alternately with chemotherapeutic projects such as HACP, HAOP, HAEP and HAMP. The relapse rate and relapse-free survival (RFS) rate in them were estimated by bone marrow examination. The total relapse rate was 14.29% (16/112), and the median time of relapse was 12.5 (4-67) months. Patients were followed up for 1-72 months, the median follow-up time being 59 months. The actual RFS rate of 1-, 2-, 3-, 4-, 5- and 6-year was 92.86%, 89.29%, 88.39%, 87.50%, 86.61% and 85.71%, respectively, while the estimated RFS rate (%) of corresponding year was 92.45 +/- 2.57, 88.25 +/- 3.20, 87.09 +/- 3.36, 85.89 +/- 3.52, 84.44 +/- 3.75 and 82.78 +/- 4.03 respectively; the relapse rate in patients who received treatment after complete response for <10 courses group was 34.29%, while in those treated for > or = 10 courses was 5.19%; and the RFS rate in them was 65.71% and 94.81% respectively, the difference between groups was statistically significant (P<0.01). The post-remission therapy mainly with CHDT is an effective and feasible program for the treatment of APL.

Tan G.,Dalian Medical University | Xu L.,Jilin University | Fang Y.,Jilin University | Tao G.,210th Hospital of PLA | And 2 more authors.
Chinese Journal of Clinical Oncology | Year: 2010

Objective: To investigate the anti-tumor effect of cytotoxic T lymphocytes (CTLs) activated by dendritic cells (DCs) pulsed with K-ras antigen. Methods: DCs were generated from PBMC in the presence of GM-CSF and IL-4 in vitro. DCs were sensitized with pancreatic cancer cell line expressing K-ras mutant, K-ras (12-Val) mutant peptide, K-ras (12-Val) mutant peptide with the surface of cationic nanoparticle. The mature DCs were cocultured with autologous T cells to obtain antigen specific CTL. The anti-tumor activity of CTL in vivo was evaluated in BALB/c nude mice bearing Patu8988 (K-ras+) and SW1990 (K-ras-) pancreatic cancer. Results: CTLs cocultured with DCs with the whole tumor antigen significantly inhibited the growth of transplanted pancreatic cancer (Patu8988 and SW1990) in nude mice. In vivo experiments showed that DCs with K-ras (12-Val) mutant peptide and K-ras mutant peptide with the surface of cationic nanoparticle induced killing activity of specific CTL aganist pancreatic cancer cell line Patu8988 (K-ras+) (P<0.05). Conclusion: CTL induced with DCs pulsed with K-ras antigen can significantly improve the survival of nude mice with pancreatic cancer, through inhibiting tumor growth.

Yang B.,210th Hospital of PLA | Wu G.,General Hospital of Shenyang Military Command | Wang X.,General Hospital of Shenyang Military Command | Zhang X.,General Hospital of Shenyang Military Command
Tumor Biology | Year: 2013

This study aims to investigate the prognostic significance of reclassification of stage IV gastric cancers in conjunction with Borrmann type. A total of 1,673 gastric cancer patients who received a gastrectomy between 1980 and 2003 were retrospectively evaluated. Of the patients, 244 (14.58 %), 344 (20.56 %), 589 (35.21 %), and 496 (29.65 %) had stage I, II, III, and IV cancers, respectively. After Cox regression analysis, Borrmann type was identified to be the independent prognostic factor in stage IV gastric cancer. The disease-specific postoperative survival of patients with Borrmann I, II, and III tumors was clearly distinguished by TNM classification system (P < 0.05), while it failed to classify Borrmann IV tumors (P = 0.147). Interestingly, the disease-specific postoperative survival of stage IV patients with Borrmann IV tumors (group 1) was significantly poor than the cases with stage IV but not Borrmann IV tumors (group 2), as well as the patients with Borrmann IV while not included in stage IV tumors (group 3) (P = 0.022 and P = 0.000, respectively). Meanwhile, the disease-specific postoperative survival was not observed as significantly different between group 2 and group 3 (P = 0.063); furthermore, group 2 + 3 had a better prognosis than group 1 (introduced stage IVa vs. stage IVb; P = 0.006). Reclassification of stage IV through combining the present TNM classification system with Borrmann type may more accurately predict the prognosis of patients. © 2013 International Society of Oncology and BioMarkers (ISOBM).

Yang X.-B.,Shenyang Pharmaceutical University | Wang X.-B.,Shenyang Pharmaceutical University | Pan W.-S.,Shenyang Pharmaceutical University | Xi R.-G.,210th Hospital of PLA | And 4 more authors.
Chemical and Pharmaceutical Bulletin | Year: 2011

In this study, dry powder formulations for inhalation of fanhuncaoin, a newly discovered antiinflammatorily active compound isolated from Chinese herb, were designed to optimize the composition and further explore the relationship between the composition, the physical properties and the aerosolization performance. Dry powders were prepared by spray-drying using leucine, chitosan, chitosan oligosaccharide and dipalmitoyl phosphatidylcholine (DPPC) as excipients. Following spray-drying, resultant powders were characterized using scanning electron microscopy, tapped density analysis, laser diffractometry, thermogravimetric analysis and differential scanning calorimetry. The aerosol behaviour of the powders was studied in a Twin Stage Impinger at an airflow rate of 60 l/min using a HandiHaler® inhaler device. Results revealed that the nature and the relative proportion of the excipients greatly influenced the physical characteristics of the powders and their aerodynamic behavior. Among the combinations tested, the composition ratio of fanhuncaoin/leucine/chitosan/ chitosan oligosaccharide/DPPC of 10/45/33.75/11.25/0.4 (w/w/w/w/w) prepared in a total solid mass of 1% (w/v) formulation was found to be particularly optimal and exhibited a tapped density of 0.44 g/cm 3, an aerodynamic diameter of 2.24 μm and an respirable fraction of 51.29%. In conclusion, optimization of the aerosolization properties of inhalation dry powders could be achieved by appropriately selecting the composition of the particles. © 2011 Pharmaceutical Society of Japan.

Wang X.-B.,210th Hospital of PLA | Wang X.-B.,Shenyang Pharmaceutical University | Xi R.-G.,210th Hospital of PLA | Yang X.-B.,210th Hospital of PLA | And 4 more authors.
Chinese Journal of New Drugs | Year: 2010

The formulation factors, including physical characteristics of dry powder inhalations, excipients and dry powder inhalers, is very important in achieving adequate delivery of inhaled drug to lungs. Here dry powder inhalations are classified into following four types (carrier-free, drug-carrier, drug-additive and drug-carrier-additive) and analyzed.

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