Song H.-T.,Jiangsu University |
Guo W.,2102 Hospital of PLA |
Sun X.-Y.,Shanghai University |
Zhang L.,Jiangsu University |
And 6 more authors.
Medical Journal of Chinese People's Liberation Army | Year: 2014
Objective To explore the correlation between the microRNA expression in plasma and psychiatric symptoms in schizophrenia patients. Methods A total of 53 consecutive schizophrenia patients who had not received antipsychotic treatment from July 2012 to May 2013 were enrolled in the present study. The expressions of 9 schizophrenia-associated microRNAs (miR- 30e, miR-34a, miR-181b, miR-195, miR-346, miR-432, miR-7, miR-132 and miR-212) in plasma were determined by real-time fluorescence quantitative PCR, with the psychiatric symptoms evaluated by Positive and Negative Symptoms Scale (PANSS), and the results were analyzed statistically. Results The expression level of miRNA-34a was significantly negatively correlated with the active symptoms and aggressive symptoms (r=-0.345, r=-0.284, P<0.05), and the expression level of miRNA-346 was significantly negatively correlated with the general psychopathologic symptoms (r=-0.282, P<0.05). The scores of activity and aggressiveness in the higher expression subgroup of miRNA-34a were significantly lower than those in lower expression subgroup (P<0.05). The score of disturbance of thought in the higher expression subgroup of miRNA-346 was significantly lower than that in lower expression subgroup (P<0.05). When miRNA-34a was entered into the two regression equations with the activity and aggressiveness as the independent variables respectively, it explained 10.2% of the variance of activity and 6.3% of the variance of aggressiveness. Source