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Changchun, China

Sun J.-H.,208 Hospital of PLA
Medical Journal of Chinese People's Liberation Army | Year: 2013

Objective To propose the concept, objects of study, tasks and roles of military medical sciences in cold regions (CM), and provide a theoretical basis and academic reference for its establishment and development. Methods Literature concerning medical sciences in cold regions were retrieved with infomatics method to analyze the research status and development of medical sciences in cold regions in the military, domestic and abroad, and venture to propose the strategy and direction of development of medical sciences in cold regions. Results CM is a comprehensive medical science composing of multiple speciaties. A large area of Chinese territory is situated in frigid area, where the garrison servicemen have to take up onerous duties, so that the establishment and development of CM should be considered as a special subject and an important specialty in military medical support. Conclusion Research work on CM in PLA is in preliminary stage. For developing CM in the future, it is suggested to integrate medical resources of CM, with the aim of gathering and rectifying interrelated medical resources, improving related medical equipment, in order to establish a basic and clinical research platform for improving the health level of garrison forces both at peacetime and during military conflicts, and also in prevention of organic and psychological diseases. Therefore, it is important to emphasize the establishment of such specialty, with an effort to accelerate team construction of science and technology of medicine of cold regions, with an increase in funding for research and improvement in improve the scientific innovation, with a purpose of safeguarding and improving the combat effectiveness of troops in cold regions.

Zhao Y.,Xiamen University | Zhang Z.,208 Hospital of PLA | Wang J.,Xiamen University | Yin P.,Xiamen University | And 6 more authors.
Artificial Organs | Year: 2012

Surgeons usually use synthetic polymer meshes for abdominal wall hernia repair. However, synthetic polymer meshes exhibit a lack of growth and related complications. In this study, we produced a tissue-engineered patch for abdominal hernia repair. Autologous bone-marrow-derived mesenchymal stem cells (BMSCs) were isolated and proliferated in vitro; decellularized dermal scaffolds (DSs) were prepared using enzymatic process; and then BMSCs were seeded onto the DSs for the construction of tissue-engineered patches. Under general anesthesia, rabbits underwent creation of abdominal wall defects and which were repaired with BMSC-seeded DSs, acellular DSs, and skin sutures only, respectively. Animals were sacrificed after 2 months for assessing the histological and gross examination. Abdominal hernias were absent in animals repaired with cell-seeded group, and abdominal hernias or bulges appeared in all animals repaired with acellular group. All the animals that were not repaired died within 10 days. The cell-seeded implants were thicker and indicated good angiogenesis compared with that of the acellular implants, both in histological and gross examination. The tissue-engineered patches prepared with BMSCs seeding on DSs can be used for abdominal wall hernia repair. © 2011, Copyright the Authors. Artificial Organs © 2011, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

Song X.-L.,Jilin University | Li B.,Jilin University | Xu K.,Jilin University | Liu J.,208 Hospital of PLA | And 5 more authors.
Cell Biology and Toxicology | Year: 2012

Silver nanoparticles (AgNPs) are being used widely and increasingly in various products and medical supplies due to their antibacterial activity. However, little is known about the impacts of the AgNPs. Herein, The primary purpose of this study was to investigate the cytotoxic effect of AgNPs in the human liver cell line (HL-7702). The watersoluble α-Methoxy-poly (ethylene glycol)-ω-mercapto (mPEG-SH)-coated AgNPs (40 nm) were synthesized, which showed superior stabilization and uniform dispersion in culture medium. The effect of mPEG-SH-coated silver nanoparticles on cell viability, leakage of lactate dehydrogenase (LDH), oxidative stress, mitochondrial membrane potential (MMP), and cell cycle was evaluated after the cells were treated with nanoparticles. The results showed that the coated AgNPs could be taken up by cells, decreased cell viability in dose- and time-dependent manners at dosage levels between 6.25 and 100.00 μg/mL, caused membrane damage (LDH leakage), and decreased the activities of superoxide dismutase and glutathione peroxides. The level of malondialdehyde, an end product of lipid peroxidation, was also increased in AgNPsexposed cells. Moreover, flow cytometric analysis showed that AgNP exposure decrease MMP and cause G 2/M phase arrest. Thus, our data suggest that mPEGSH- coated AgNPs have the potential toxicity that is associated with oxidative stress, apoptosis, and DNA damage. © Springer Science+Business Media B.V. 2012.

Xu K.-X.,208 Hospital of PLA | Tao J.,Wendeng Osteopath Hospital | Zhang N.,Renji Hospital | Wang J.-Z.,208 Hospital of PLA
International Journal of Clinical and Experimental Medicine | Year: 2015

Obesity has been reported to be one of the significant contributors to various chronic disease conditions. Childhood obesity has been on an alarming increase over recent years leading to various health complications. Millions of children undergo surgery each year as a part of medical care on various health grounds. In the present study, influence of vitamin C on the effect of obesity and over-weight under anaesthetic exposure was analysed. Separate groups of neonatal mice (C57BL/6) were fed on high-fat diet to induce obesity. The mice were administered with vitamin C at 30 and 60 mg/kg b.wt post natal day 1 (P1) to P21. P7 mice were exposed to equipotent doses of isoflurane or sevoflurane or desflurane. Neuroapoptosis was assessed by measuring activated caspase-3 and TUNEL assay. Plasma S100β levels were detected by ELISA. The mice were assessed for their general behaviour. Morris water maze test was performed to assess the spatial working memory. Anesthesia exposure caused severe neuroapoptosis and also raised the levels of plasma S100β. Neuroapotosis, working memory and learning impairments observed following anesthetics were comparatively more profound on high fat diet fed mice. Desflurane exposure resulted in higher apoptotic counts, learning and memory deficits than equipotent dose of isoflurane and sevoflurane. Vitamin C supplementation offered significant protection against anesthetic induced neurotoxicity and behavioural alterations. Vitamin C administration resulted in marked reduction in neurotoxicity induced by anesthesia and as well improved learning and memory of both normal and high fat diet fed mice. © 2015 E-Century Publishing Corporation. All rights reserved.

Li P.,General Hospital of Shenyang Military Command | Liang L.-L.,General Hospital of Shenyang Military Command | Zhang S.-W.,202 Hospital of PLA | An L.,210 Hospital of PLA | And 9 more authors.
Medical Journal of Chinese People's Liberation Army | Year: 2014

Objective: To investigate the integrated control levels of hemoglobin A1c(HbA1c), systolic and diastolic blood pressure (BP), low-density lipoprotein cholesterol (LDL-C) in retired army cadres suffering from type 2 diabetes (T2DM) in northeast China.Methods: Four hundred and seventy-seven retired army cadres (aged ≥50 years) with T2DM were interviewed using questionnaire. The subjects were assigned into two groups according to the presence (n=350) or without (n=127) cardiovascular disease (CVD), and then the control levels of HbA1c, fast blood glucose (FBG), 2-hour postprandial blood glucose (2hPG), BP, blood cholesterol (TC), triglycide (TG), high-density lipoprotein cholesterol (HDL-C) and LDL-C were compared between the two groups.Results: The overall successful rate of control of HbA1c(<7%) was 65.8%. The overall successful rate of controling HbA1cin diabetic patients without CVD was significantly higher than in those with CVD (74.8% vs 56.9%, χ2=13.857, P<0.05). The overall successful rate for controling LDL-C in enrolled subjects (<2.6mmol/L) was 47.8%. The overall successful rate for controling LDL-C in patients without CVD (<2.6mmol/L) was significantly higher than in those with CVD (<1.8mmol/L) (47.2% vs 23.9%, χ2=6.77, P<0.05). In 85.5% of patients the target of controling blood pressure (<140/80mmHg) was achieved. The successful rates were almost identical between the with- and without-CVD groups (85.1% vs 86.4%, χ2=0155, P>0.05). The comprehensive attainment rate for controling HbA1c, BP and LDL-C among all the subjects was 23.5%, and no significant difference was found between with- and without-CVD subjects (22.9% vs 25.1%, χ2=0.284, P>0.05).Conclusions: Under the military health care management system, the unique and comprehensive successful rate for controling HbA1c, BP and LDL-C was higher among retired army cadres in northeast China as compared with that in non-military Chinese populations, and it is close to, even higher than the reported levels abroad. The successful rate shows no difference between with- or without-CVD subjects. © 2014, People's Military Medical Press. All rights reserved.

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