Li W.,University of Sichuan |
Liu Y.,University of Sichuan |
Lu X.,University of Sichuan |
Huang Y.,University of Sichuan |
And 3 more authors.
Journal of Breath Research
Breath acetone is a known biomarker for diabetes mellitus in breath analysis. In this work, a cross-sectional study of breath acetone based on clinical metabolic disorders of type 2 diabetes mellitus (T2DM) was carried out. Breath acetone concentrations of 113 T2DM patients and 56 apparently healthy individuals were measured at a single time point. Concentrations varied from 0.22 to 9.41 ppmv (mean 1.75 ppmv) for T2DM, which were significantly higher than those for normal controls (ranged from 0.32 to 1.96 ppmv, mean 0.72 ppmv, p = 0.008). Observations in our work revealed that breath acetone concentrations elevated to different degrees, along with the abnormality of blood glucose, glycated hemoglobin (HbA1c), triglyceride and cholesterol. Breath acetone showed obviously positive correlations with blood ketone and urine ketone. Possible metabolic relations between breath acetone and diabetic disorders were also discussed. This work aimed at giving an overall assessment of breath acetone from the perspective of clinical parameters for type 2 diabetes. © 2015 IOP Publishing Ltd. Source
Zhang L.-B.,208 Hospital of Peoples Liberation Army |
Yang H.-S.,Jilin University |
Cao S.,208 Hospital of Peoples Liberation Army |
Fan S.,208 Hospital of Peoples Liberation Army |
And 2 more authors.
Objective: To evaluate the clinical value of percutaneous transhepatic cholangial drainage (PTCD) and percutaneous transhepatic cholangial stent (PTCS) implantation therapy for malignant biliary obstruction in the elderly patients. Methods: Fifty three patients over 60 years-old were treated with PTCS implantation (n=35), PTCD for internal-external drainage (n=11), or single external drainage (n=7). The imaging examination was performed for all the patients one week after surgery. The serum levels of total bilirubin (TBIL) and alanine aminotransferase (ALT) were detected before and after surgery. Rusults: Metallic stents were successfully implanted in 32 patients during the surgery, and 3 patients were implanted 5 to 7 days later after PTCS. Both total serum levels of TBIL and ALT were significantly decreased at one week after surgery (P<0.05). The mean survival periods were 11.5 months for stent implantation patients and 5.5 months for PTCD patients. Conclusion: PTCD and PTCS are easy to perform and safe and effective in the treatment of malignant biliary obstruction of elderly patients. Source