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Cattopadhyay K.,Haldia Institute of Technology | Recio Iii A.,2010 Malott Hall | Tunge J.A.,2010 Malott Hall
Organic and Biomolecular Chemistry | Year: 2012

We report the palladium-catalyzed, pyrrolidine-mediated α-benzylation of enamines generated from aldehydes and ketones. The method allows for direct coupling of medicinally relevant coumarin moieties with aldehydes and ketones in good yield under mild conditions. The reaction is believed to proceed via a Pd-π-benzyl complex generated from (coumarinyl)methyl acetates. © 2012 The Royal Society of Chemistry.

Recio A.,2010 Malott Hall | Heinzman J.D.,2010 Malott Hall | Tunge J.A.,2010 Malott Hall
Chemical Communications | Year: 2012

Decarboxylative benzylation of nitriles is achieved via coupling of metallated nitriles with Pd-π-benzyl complexes that are generated in situ from cyanoacetic benzyl esters. In addition, decarboxylative couplings of α,α-disubstituted 2-methylfuranyl cyanoacetates can lead to either decarboxylative arylation or benzylation depending on the reaction conditions. © 2012 The Royal Society of Chemistry.

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