Sayan M.,University of KocaeliKocaeli |
Sayan M.,Near East University |
Gunduz A.,Educational and Research Hospital |
Ersoz G.,Mersin University |
And 14 more authors.
HIV Clinical Trials | Year: 2016
Objectives: Integrase strand transfer inhibitor (INSTI) is a new class of antiretroviral (ARV) drugs designed to block the action of the integrase viral enzyme, which is responsible for insertation of the HIV-1 genome into the host DNA. The aim of this study was to evaluate for the first time INSTI resistance mutations in Turkish patients. Methods: This study was conducted in Turkey, between April 2013 and April 2015 using 169 HIV-1-infected patients (78 ARV naive patients and 91 ARV-experienced patients). Laboratory and clinical characteristics of ARV naive and ARV-experienced patients were as follows: gender (M/F): 71/7 and 80/11, median age: 38 and 38.4; median CD4+ T-cell: 236 and 216 cells/mm3, median HIV-1 RNA: 4.95+E5 and 1.08E+6 copies/ml. Population-based seqeunces of the reverse transcriptase, protease, and integrase domains of the HIV-1 pol gene were used to detect HIV-1 drug resistance mutations. Result: INSTI resistance mutations were not found in recently diagnosed HIV-1-infected patients. However, ARV-experienced patients had major resistance mutations associated with raltegravir and elvitegravir; the following results were generated:F121Y, Y143R, Q148R and E157Q (6/91 – 6.6%). Conclusions: The prevalence of INSTI resistant mutations in ART-experienced patients suggested that resistance testing must be incorporated as an integral part of HIV management with INSTI therapies. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Erturk U.,Uludag University |
Mert C.,Uludag University |
Soylu A.,Uludag University |
Akca Y.,University of 19 Mayis |
Okay Y.,Ankara University
Acta Horticulturae | Year: 2014
This study was carried out to evaluate some domestic ('Bilecik', 'Maraş 12', 'Maraş 18', 'Şebin Şen1', 'Şen 2') and foreign walnut cultivars ('Chandler', 'Fernette', 'Fernor', 'Howard', 'Pedro', 'Serr') in the conditions of Bursa, northwest Turkey (latitude 40°11' and longitude 29°3') between 2008 and 2012. The cultivars were compared according to leafing time, bloom period of staminate and pistillate flowers, leaf fall, tree vigour and fruit characteristics. The earliest leafing was observed in the cultivar 'Maraş 12' and the latest leafing were noted in 'Fernette' and 'Fernor'. First female flowers appeared at the end of April in the 'Serr' cultivar, while the female flowers in 'Fernor' appeared at the end of May. Catkins flowered between mid-April in 'Sebin' and the end of May in 'Fernor'. Flowering of 'Sen 1' and 'Sen 2' was homogamous, the flowering of 'Bilecik' was protogynous, and other cultivars were protandrous. The earliest leaf fall was observed in 'Sen1', 'Sen 2', 'Sebin', 'Maras 12' and 'Maras 18' and the latest leaf fall was seen in 'Howard', 'Pedro' and 'Chandler'. 'Sen 1', 'Bilecik', 'Chandler' 'Maraş 12', 'Fernor', 'Pedro' exhibited higher vigour than other cultivars. All cultivars produced nuts in 2012. The fruit weight of cultivars ranged between 9.86 g ('Maraş 12') and 16.80 g ('Şen 1'). The shell thickness varied between 1.62 mm ('Sen 1') and 2.67 mm ('Howard'). The percent kernel was highest in 'Sebin' (57.22%).
Koker M.Y.,Erciyes University |
Camcioglu Y.,Istanbul University |
Van Leeuwen K.,University of Amsterdam |
Kilic S.S.,Uludag University |
And 11 more authors.
Journal of Allergy and Clinical Immunology | Year: 2013
Background Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder of phagocytes resulting in impaired killing of bacteria and fungi. A mutation in one of the 4 genes encoding the components p22phox, p47phox, p67phox, and p40 phox of the leukocyte nicotinamide dinucleotide phosphate reduced (NADPH) oxidase leads to autosomal recessive (AR) CGD. A mutation in the CYBB gene encoding gp91phox leads to X-linked recessive CGD. Objective The aim of this study is to show the correlation between clinical, functional, and genetic data of patients with CGD from Turkey. Methods We report here the results of 89 patients with CGD from 73 Turkish families in a multicenter study. Results Most of the families (55%) have an AR genotype, and 38% have an X-linked genotype; patients from 5 families with a suspected AR genotype (7%) were not fully characterized. We compared patients with CGD according to the severity of NADPH oxidase deficiency of neutrophils. Patients with A22 0, A670 or X910 phenotypes with a stimulation index of 1.5 or less have early clinical presentation and younger age at diagnosis (mean, 3.2 years). However, in p47phox-deficient cases and in 5 other AR cases with high residual oxidase activity (stimulation index ≥ 3), later and less severe clinical presentation and older age at diagnosis (mean, 7.1 years) were found. Pulmonary involvement was the most common clinical feature, followed by lymphadenitis and abscesses. Conclusion Later and less severe clinical presentation and older age at diagnosis are related to the residual NADPH oxidase activity of neutrophils and not to the mode of inheritance. CGD caused by A220 and A670 subtypes manifests as severe as the X910 subtype. © 2013 American Academy of Allergy, Asthma & Immunology.