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Salt Lake City, UT, United States

We present here the construction of a DNA biosensor based on a tubular micromotor that only produces motion-based signal in the presence of DNA target. This "turn on" characteristic of the sensor is achieved by the addition of Pt nanoparticle-DNA conjugate as the motion-inducing catalyst for the micromotors through DNA hybridization. Our work potentially offers new design strategies for motion-based biosensors with higher specificity. This journal is © The Royal Society of Chemistry 2015. Source

Van Nguyen K.,15 S 1400 E | Minteer S.D.,15 S 1400 E
Chemical Communications

We report the usage of DNA hydrogels for enzyme entrapment in an enzymatic biobattery. With the recent advancements in DNA nanotechnology, the incorporation of DNA materials to bioelectrocatalytic electrodes holds great promise to improve the performance of bioelectrocatalysis-based devices. © 2015 The Royal Society of Chemistry. Source

Campbell E.,Columbia University | Meredith M.,15 S 1400 E | Minteer S.D.,15 S 1400 E | Banta S.,Columbia University
Chemical Communications

The performance of immobilized enzyme systems is often limited by cofactor diffusion and regeneration. Here, we demonstrate an engineered enzyme capable of utilizing the minimal cofactor nicotinamide mononucleotide (NMN +) to address these limitations. Significant gains in performance are observed with NMN + in immobilized systems, despite a decreased turnover rate with the minimal cofactor. © 2012 The Royal Society of Chemistry. Source

Abdellaoui S.,15 S 1400 E | Hickey D.P.,15 S 1400 E | Stephens A.R.,15 S 1400 E | Minteer S.D.,15 S 1400 E
Chemical Communications

The complete electro-oxidation of glycerol to CO2 is performed through an oxidation cascade using a hybrid catalytic system combining a recombinant enzyme, oxalate decarboxylase from Bacillus subtilis, and an organic oxidation catalyst, 4-amino-TEMPO. This system is capable of electrochemically oxidizing glycerol at a carbon electrode collecting all 14 electrons per molecule. © 2015 The Royal Society of Chemistry. Source

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