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Breitenfurt bei Wien, Austria

Engberding R.,I. Medizinische Klinik | Stollberger C.,Medizinische Abteilung | Ong P.,Robert Bosch GmbH | Yelbuz T.M.,Abteilung fur Padiatrische Kardiologie und Intensivmedizin | And 2 more authors.
Deutsches Arzteblatt | Year: 2010

Background: Isolated non-compaction cardiomyopathy (NCCM) was first described in 1984. This disorder, a primary genetic cardiomyopathy, is now attracting increased attention. Method: The current state of the epidemiology, pathogenesis, pathophysiology, clinical features, diagnosis, treatment, and prognosis of NCCM are discussed on the basis of a review of selected literature as well as the authors' personal experience. Results: The pathogenesis of NCCM is thought to involve a genetically determined disturbance of the myocardial compaction process during fetal endomyocardial morphogenesis. It is not accompanied by any other cardiac anomalies. Echocardiography is the diagnostic method of choice. The diagnosis is based on the following echocardiographic criteria: the presence of at least 4 prominent trabeculations and deep intertrabecular recesses, blood flow from the ventricular cavity into the intertrabecular recesses, and a typical bilaminar structure of the affected portion of the left ventricular myocardium. NCCM can also be diagnosed with magnetic resonance imaging of the heart. The clinical severity of NCCM is variable; its manifestations include heart failure, thromboembolic events, and arrhythmias. The treatment is symptom-based. Patients with symptomatic NCCM have a poor prognosis. Conclusion: NCCM is a type of cardiomyopathy that was first described 25 years ago. Its molecular genetic basis is not yet fully clear, and the same is true of its diagnosis, treatment, and prognosis. Further study of these matters is needed. Source


Wascher T.C.,Medizinische Abteilung
Wiener Klinische Wochenschrift | Year: 2012

Self monitoring of blood glucose contributes to the integrated management of diabetes mellitus. It, thus, should be available for all patients with diabetes mellitus type-1 and type-2. Self monitoring of blood glucose improves patients safety, quality of life and glucose control. The current article represents the recommendations of the Austrian Diabetes Association for the use of blood glucose self monitoring according to current scientific evidence. © 2012 Springer-Verlag Wien. Source


Stollberger C.,Krankenanstalt Rudolfstiftung | Finsterer J.,Medizinische Abteilung
European Journal of Echocardiography | Year: 2011

Left ventricular non-compaction is a cardiac abnormality whose echocardiographic diagnostic criteria are still controversial. The distinction between normal and pathologic is additionally impeded by the fact that the left ventricular myocardium is more intensively trabeculated in African blacks than in Caucasians. The impact of these uncertainties and unresolved issues in the diagnosis of non-compaction is illustrated by a 23-year-old professional African footballer in whom an aberrant left ventricular band was misinterpreted as non-compaction. The diagnosis of non-compaction resulted in the immediate withdrawal of the playing licence and impending deportation of the young man from Germany to his home country. Organized by the footballers lawyer, repeated echocardiographies and cardiac magnetic resonance imaging failed to diagnose non-compaction. After several months, the young man regained his playing licence and played as a striker in the national team of his country of origin in the football world cup. Uncertainties and unresolved issues may result in misdiagnosis of non-compaction, thus promoting discrimination and degradation. This case highlights the urgent need for standardization of diagnostic criteria for left ventricular non-compaction and to assess if they need to be different for African blacks and Caucasians. © 2010 The Author. Source


Schuchardt J.P.,Leibniz University of Hanover | Neubronner J.,Leibniz University of Hanover | Kressel G.,Leibniz University of Hanover | Merkel M.,Medizinische Abteilung | And 2 more authors.
Prostaglandins Leukotrienes and Essential Fatty Acids | Year: 2011

Recently, in a supplementation study over six months, it has been demonstrated that re-esterified omega-3 fatty acid triacylglycerols (n3-FA-rTAGs) led to a higher increase in omega-3-index compared to identical doses of n3-FA ethyl-esters (n3-FA-EEs), suggesting a better long-term bioavailability. The aim of this study was to examine whether differences occur between the two forms in affecting fasting serum lipid levels. 150 dyslipidemic statin-treated participants were randomized to corn oil as a placebo or fish oil either as rTAG or EE in identical doses (1.01 g EPA+0.67 g DHA). No changes in total cholesterol, HDL or LDL levels were observed. In the rTAG-group, but not in the EE-group, fasting serum TAG levels were significantly reduced from baseline after three and six months. There was no significant difference between the two n3-FA-groups. However, serum TAG levels were significantly lowered after six months in the rTAG-group compared to the placebo-group in contrast to the EE-group. © 2011 Elsevier Ltd. Source


Wascher T.C.,Medizinische Abteilung | Stechemesser L.,Paracelsus Medical University
Wiener Klinische Wochenschrift | Year: 2016

Self monitoring of blood glucose contributes to the integrated management of diabetes mellitus. It, thus, should be available for all patients with diabetes mellitus type-1 and type-2. Self monitoring of blood glucose improves patients safety, quality of life and glucose control. The current article represents the recommendations of the Austrian Diabetes Association for the use of blood glucose self monitoring according to current scientific evidence. © 2016, Springer-Verlag Wien. Source

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