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Montréal, Canada

Conway J.W.,01 Sherbrooke St. West | McLaughlin C.K.,01 Sherbrooke St. West | Castor K.J.,01 Sherbrooke St. West | Sleiman H.,01 Sherbrooke St. West
Chemical Communications | Year: 2013

Simple chemical modifications to oligonucleotide ends with hexaethylene glycol and hexanediol are shown to significantly increase nuclease resistance under serum conditions. The modified oligonucleotides were used to construct DNA prismatic cages in a single step and in quantitative yield. These cages further stabilize their strands towards nucleases, with lifetimes of 62 hours in serum. The cages contain a large number of single-stranded regions for functionalization, illustrating their versatility for biological applications. This journal is © 2013 The Royal Society of Chemistry. Source


McLaughlin C.K.,01 Sherbrooke St. West | Hamblin G.D.,01 Sherbrooke St. West | Aldaye F.A.,01 Sherbrooke St. West | Yang H.,01 Sherbrooke St. West | Sleiman H.F.,01 Sherbrooke St. West
Chemical Communications | Year: 2011

We describe a rapid and quantitative method to generate DNA cages of deliberately designed geometry from readily available starting strands. Balancing the incorporation of sequence uniqueness and symmetry in a face-centered approach to 3D construction can result in triangular (TP), rectangular (RP), and pentagonal prisms (PP) without compromising the potential for nanostructure addressability. © 2011 The Royal Society of Chemistry. Source

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