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Kenilworth, NJ, United States

Imbriglio J.E.,000 Galloping Hill Road | Shen D.-M.,000 Galloping Hill Road | Liang R.,000 Galloping Hill Road | Marby K.,000 Galloping Hill Road | And 27 more authors.
Journal of Medicinal Chemistry | Year: 2015

DGAT2 plays a critical role in hepatic triglyceride production, and data suggests that inhibition of DGAT2 could prove to be beneficial in treating a number of disease states. This article documents the discovery and optimization of a selective small molecule inhibitor of DGAT2 as well as pharmacological proof of biology in a mouse model of triglyceride production. © 2015 American Chemical Society.

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