Imbriglio J.E.,000 Galloping Hill Road |
Shen D.-M.,000 Galloping Hill Road |
Liang R.,000 Galloping Hill Road |
Marby K.,000 Galloping Hill Road |
And 27 more authors.
Journal of Medicinal Chemistry
DGAT2 plays a critical role in hepatic triglyceride production, and data suggests that inhibition of DGAT2 could prove to be beneficial in treating a number of disease states. This article documents the discovery and optimization of a selective small molecule inhibitor of DGAT2 as well as pharmacological proof of biology in a mouse model of triglyceride production. © 2015 American Chemical Society. Source