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Baltimore Highlands, MD, United States

Meng S.,00 N. Wolfe St | Cao J.,00 N. Wolfe St | He Q.,00 N. Wolfe St | Xiong L.,00 N. Wolfe St | And 4 more authors.
Journal of Biological Chemistry | Year: 2015

Background: The mechanism underlying the activation of AMPK by metformin remains unclear. Results: Metformin promotes the formation of AMPK αβγ heterotrimeric complex. Conclusion: The formation of the AMPK αβγ heterotrimeric complex augments AMPK αβγ phosphorylation by LKB1 and prevents dephosphorylation by protein phosphatase. Significance: Metformin-mediated formation of the AMPK αβγ heterotrimeric complex results in AMPK activation by elevating AMPK phosphorylation at Thr-172. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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