Vaudaux J.D.,University of California at Los Angeles |
Vaudaux J.D.,University of Lausanne |
Muccioli C.,Federal University of São Paulo |
James E.R.,University of British Columbia |
And 10 more authors.
Journal of Infectious Diseases | Year: 2010
Multilocus DNA sequencing has identified a nonarchetypal strain of Toxoplasma gondii as the causal agent of a waterborne outbreak in Brazil in 2001. The strain, isolated from a water supply epidemiologically linked to the outbreak, was virulent to mice, and it has previously been identified as BrI. Using a serologic assay that detects strain-specific antibodies, we found that 13 (65%) of 20 individuals who were immunoglobulin (Ig) M positive during the outbreak possessed the same serotype as mice infected with the purported epidemic strain. The remaining 7 individuals, plus additional IgM-negative, IgG-positive individuals, possessed 1 of 4 novel serotypes, the most common of which matched the serotype of mice infected with strains isolated from chickens foraging near the outbreak site. The latter strains likely reflect the genetic diversity of T. gondii circulating in highly endemic regions of Brazil. The serotyping assay proved a useful tool for identification of specific individuals infected with the outbreak agent. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Belfort M.,University at Albany |
Marraffini L.,Rockefeller University |
Macfarlan T.,Center Dr |
Boeke J.,New York University |
And 3 more authors.
Mobile DNA | Year: 2014
During the Mobile Genetic Elements and Genome Evolution Keystone Symposium in March 2014, the Editors of Mobile DNA caught up with a panel of conference speakers to select key advances in the field, and hear their thoughts on where mobile DNA research is going. © 2014 Belfort et al.; licensee BioMed Central Ltd.